Sulfuric Acid → Ethyl 2-(3-bromo-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-5-ylmethylcarbamoyl)indole-1-acetate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

9-Bromo-4-(2-chlorophenyl)-2-ethyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine is added to 2M sulfuric acid, and the mixture is stirred at 80° C. overnight. Sodium hydrogencarbonate is added to the reaction mixture to make the mixture alkaline. Chloroform and 1-ethoxycarbonylmethylindole-2-carbonyl chloride are added, and the mixture is stirred at room temperature for 2 hours to give ethyl 2-(3-bromo-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-5-ylmethylcarbamoyl)indole-1-acetate.

Herkunft & Nachweise