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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 964458Erstellt: 23. Oktober 2026

Tetrabutylammonium Fluoride → 2,6-Dipropyl-4-(2-hydroxyethyl)phenol

https://huagongshe.com/de/reaction/964458

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktTetrabutylammonium FluorideHCID 2724141—
Eduktt-Butyldimethylsilyloxy-2,6-dipropyl-4-(2-hydroxyethyl)-benzeneHCID 19080442—
LösungsmittelTetrahydrofuranHCID 8028—
Produkt2,6-Dipropyl-4-(2-hydroxyethyl)phenolHCID 19080373170,6%

Reaktionsschritte

To a solution of 1.0 g (2.98 mmol) of the product of Step C in 3.0 mL of THF was added 3.57 mL (3.57 mmol) of 1.0N solution of tetrabutylammonium fluoride in THF. After 15 minutes TLC indicated that the reaction was complete. The reaction mixture was concentrated and then purified by flash chromatography (silica gel, hexane/ethyl acetate 3:1) to give 1.13 g of the title compound.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS05767310
Quelldatensatzuspto-grants-1998_06
ORD IDord-12ae317766c64999bd88ae188a0b1199
Quellennotizuspto-grants-1998_06