Dicyclohexylcarbodiimide → methyl (2RS,5SR)-3-{3-{2-[2-(2-methoxyphenyl)-5-phenyl-1-pyrrolidinyl]-2-oxoethyl}ureido}phenylacetate

Beteiligte Stoffe

Reaktionsschritte

Methyl cis-3-{3-{2-[2-(2-methoxyphenyl)-5-phenyl-1-pyrrolidinyl]-2-oxoethyl}ureido}phenylacetate may be prepared in a fashion similar to that described in Example 41 §A, but starting from 0.57 g of (2RS,5SR)-2-(2-methoxyphenyl)-5-phenyl-pyrrolidine, 0.6 g of 2-[3-(3-methoxycarbonylmethylphenyl)ureido]acetic acid and 0.46 g of N,N'-dicyclohexylcarbodiimide in 4.5 cm3 of acetonitrile. After treatment, 1.2 g of methyl (2RS,5SR)-3-{3-{2-[2-(2-methoxyphenyl)-5-phenyl-1-pyrrolidinyl]-2-oxoethyl}ureido}phenylacetate are obtained in the form of an oil used as it is in subsequent syntheses.

Herkunft & Nachweise