HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Bromotoluene → 2-(3-Methylphenyl)benzonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Bromotoluene | HCID 11560 | — |
| Edukt | 2-Bromobenzonitrile | HCID 16272 | — |
| Edukt | HCID 178418306 | HCID 178418306 | — |
| Katalysator | Zincchloride | HCID 3007855 | — |
| Katalysator | HCID 178420538 | HCID 178420538 | — |
| Produkt | 2-(3-Methylphenyl)benzonitrile | HCID 1394243 | 46,7% |
Reaktionsschritte
3-Bromotoluene (17.5 mmoles, 3.0 g) was reacted with t-BuLi (19.3 moles) and ZnCl2 (19.3 mmoles, 2.62 g) followed by a Ni(PPh3)4 coupling to 2-bromobenzonitrile (17.5 mmole, 3.2 g) as in Preparation 1. The intermediate was purified by chromatography over silica gel eluted with 20% ether in hexane to yield 1.58 g of 2-(3-methylphenyl)-benzonitrile (MS)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05612360 |
| Quelldatensatz | uspto-grants-1997_03 |
| ORD ID | ord-9ccc724f711f4fd3835b9e850991d580 |
| Quellennotiz | uspto-grants-1997_03 |