1,3-dimethyl-4-nitro-1H-pyrazole-5-carboxamide → 4-amino-1,3-dimethyl-1H-pyrazole-5-carboxamide

Beteiligte Stoffe

Reaktionsschritte

Fifty grams of 1,3-dimethyl-4-nitro-pyrazole-5-carboxamide as prepared in Preparation 2 is dissolved in methanol, 2 g 50% of Raney nickel is added, and the compound is reduced under a hydrogen atmosphere until a 8.15 pound drop in pressure noted. The reaction mixture was filtered, the filtrate concentrated, and the crude material recrystallized in ethyl acetate to yield the product, 1,3-dimethyl-4-amino-pyrazol-5-carboxamide mp 154°-155° C.

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