Leucine-beta-naphthylamide

HCID 102475CAS 732-85-4
Substructure searchFind similar structures

Basic information

Standard SMILES
CC(C)C[C@H](N)C(=O)Nc1ccc2ccccc2c1
InChIKey
JWHURRLUBVMKOT-HNNXBMFYSA-N
Molecular formula
C16H20N2O
Average molar mass
256.34 g/mol
Monoisotopic mass
256.15756326

Overview

L-leucine 2-naphthylamide is an L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of L-leucine with the amino group of 2-naphthylamine. It has a role as a chromogenic compound. It is an amino acid amide, a L-leucine derivative and a N-(2-naphthyl)carboxamide.

Names & identifiers

Preferred name
Leucine-beta-naphthylamide
IUPAC
(2S)-2-amino-4-methyl-N-naphthalen-2-ylpentanamide
English name
L-Leucine beta-naphthylamide
Molecular formula
C16H20N2O
Molecular weight
256.34

Names & synonyms

732-85-4Leucine-beta-naphthylamideleucine-2-naphthylamideLeu-NapPentanamide, 2-amino-4-methyl-N-2-naphthalenyl-, (S)-RefChem:153063211-990-0L-Leucine beta-naphthylamideH-Leu-bNA(S)-2-Amino-4-methyl-N-(naphthalen-2-yl)pentanamideN-(2-Naphthyl)-L-leucinamideH-Leu-betaNA
Show more names
H-Leu-βNAL-Leu-NNapLEUCINE-BETANAEinecs 211-990-0Leu-β-naphthylamidel-leucine β-naphthylamideL-LEUCINE-2-NAPHTHYLAMIDE
L-leucine 2-naphthylamideL-Leucine-beta-naphthylamide(2S)-2-amino-4-methyl-N-naphthalen-2-ylpentanamide(S)-2-Amino-4-methyl-N-2-naphthylvaleramideL-?Leucine-??-?naphthylamide2-Amino-4-methyl-N-(2-naphthyl)pentanamiden-naphthalen-2-yl-l-leucinamideL-Leucine-|A-naphthylamide

Database identifiers

CAS
732-85-4
PubChem CID
102475
DTXSID
DTXSID20993920
ChEMBL
CHEMBL22905
ChEBI
CHEBI:90476
EC Number
211-990-0
Nikkaji
J193.101F

Properties

Computed structural properties

XLogP
3.2
Topological polar surface area
55.1 Ų
Hydrogen bond donors
2
Hydrogen bond acceptors
2
Rotatable bonds
4
Heavy atoms
19

Physicochemical properties

storage temp.
-20 °C · -20°C
solubility
2 O: · H2O: insoluble
form
powder
Water Solubility
2 O: · H2O: insoluble
InChI
1S/C16H20N2O/c1-11(2)9-15(17)16(19)18-14-8-7-12-5-3-4-6-13(12)10-14/h3-8,10-11,15H,9,17H2,1-2H3,(H,18,19)/t15-/m0/s1
InChIKey
JWHURRLUBVMKOT-HNNXBMFYSA-N

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H351 (97.5%): Suspected of causing cancer [Warning Carcinogenicity]

P203, P280, P318, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory.

Hazard information

Hazard Classes and CategoriesCarc. 2 (97.5%)

Safety data

PPE
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
wgk
3
hs_code
29242990
risk_code
40
Signal word
Warning
Symbol(GHS)
GHS08

Chemistry & industry

Applications · 2 items

UsesL-Leucine-β-naphthylamide is used in the synthesis of protein tyrosine phosphatase inhibitors. Used as an agent to combat Leishmania major.

UsesL-Leucine β-naphthylamide has been used as a substrate:to measure the activity of aminopeptidase in Escherichia colito evaluate the enzyme activity of cathepsin H from rabbit skeletal musclesin the proteolytic assay of L-Leucine aminopeptidase

Suppliers19 total

上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]

Additional notes

DefinitionChEBI: An L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of L-leucine with the amino group of 2-naphthylamine.

Related reactions

1 records
New reaction record

Linked notes

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