3,5-Dihydroxyphenylglycine

HCID 108001CAS 146255-66-5

Completing data — usually done within a minute

Substructure search Find similar structures

Basic information

Standard SMILES: NC(C(=O)O)c1cc(O)cc(O)c1
InChIKey: HOOWCUZPEFNHDT-UHFFFAOYSA-N
Molecular formula: C8H9NO4
Average molar mass: 183.163 g/mol
Monoisotopic mass: 183.05315777

Names & identifiers

Preferred name: 3,5-Dihydroxyphenylglycine
IUPAC: Amino(3,5-dihydroxyphenyl)acetic acid
English name: (RS)-3,5-DHPG
Molecular formula: C8H9NO4
Molecular weight: 183.16

Names & synonyms

3,5-dihydroxyphenylglycine2-amino-2-(3,5-dihydroxyphenyl)acetic acid(RS)-3,5-DHPGDHPG ((RS)-3，5-DHPG)DL-3,5-dihydroxyphenylglycine(RS)-3,5-DIHYDROXYPHENYLGLYCINEDL-ALPHA-(3,5-DIHYDROXYPHENYL)GLYCINEBenzeneacetic acid, α-amino-3,5-dihydroxy-a-Amino-3,5-dihydroxy-benzeneacetic acid HCl(R,S)-3,5-DHPG, group I mGlu receptor agonist

Database identifiers

CAS: 146255-66-5
PubChem CID: 108001
DTXSID: DTXSID901311536
ChEMBL: CHEMBL66105
ChEBI: CHEBI:93822
UNII: 5YR2N37E6D
Nikkaji: J847.101K

Properties

Physicochemical properties

Boiling point: 448.8 · 448.8±33.0 °C(Predicted)
Density: 1.55 · 1.550±0.06 g/cm3(Predicted)
storage temp.: -20 °C · Store at -20°C
solubility: 1 mg/ml; · DMSO: 1 mg/ml; Water: 1 mg/ml
form: A solid
pka: 1.77 · 1.77±0.10(Predicted)
color: White
Water Solubility: Soluble in water (10mM)
Stability: Hygroscopic
FDA UNII: 5 YR2N37E6D · 5YR2N37E6D
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 302 · H302-H315-H319-H335
Precautionary statements: 261 · P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

Safety & regulation

Safety data

Signal word: Warning
Symbol(GHS): GHS07
Hazard statements: H302-H315-H319-H335
Precautionary statements: P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

Chemistry & industry

Applications · 1 item

Uses(RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGluR1 and mGluR5. It has been shown that (RS)-3,5-DHPG can modulate Kir4.1 protein and mRNA in cultured rat retinal Müller cells.(RS)-3,5-DHPG acts as a potential target in treatment of parkinson''s disease.