Ppads tetrasodium salt
PPADS · PPADS Tetrasodium · 4'-disulfonic acid · PPADS (sodium salt) · PPADS TETRASODIUM SALT · PPADS tetrasodium salt hydrate · PPADS tetrasodium salt, anhydrous · Pyridoxalphosphate-6-azophenyl-2'
Identifiers & Physical Properties
| CAS No. | 192575-19-2 |
|---|---|
| Molecular formula | C14H10N3Na4O12PS2 |
| Average molar mass | 599.3 g/mol |
| SMILES | Cc1nc(N=Nc2ccc(S(=O)(=O)[O-])cc2S(=O)(=O)[O-])c(COP(=O)([O-])[O-])c(C=O)c1O.[Na+].[Na+].[Na+].[Na+] |
| InChIKey | JTTDHFFNVGHDLN-YDTRVRFHSA-J |
| PubChem CID | 135484645 |
| ChEMBL | CHEMBL1256743 |
| ChEBI | CHEBI:91080 |
| DTXSID | DTXSID201017674 |
Chemical & Physical Properties
| Topological polar surface area | 278 |
|---|---|
| Hydrogen bond donors | 1 |
| Hydrogen bond acceptors | 15 |
| Rotatable bonds | 5 |
| Heavy atoms | 36 |
| Formal charge | 0 |
| Complexity | 918 |
| Storage conditions | −20°C |
| Solubility | H2O: >10 mg/mLSoluble to 100 mM in water |
| Physical state | solid |
| Color | red to orange |
| Stability | Unstable in Aqueous Solution |
| InChIKey | JTTDHFFNVGHDLN-YDTRVRFHSA-J |
| SMILES | O.[Na+].[Na+].[Na+].[Na+].Cc1nc(\N=N\c2ccc(cc2S([O-])(=O)=O)S([O-])(=O)=O)c(COP([O-])([O-])=O)c(C=O)c1O |
| UNSPSC Code | 12352106 |
| NACRES | NA.77 |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H315-H319-H335 |
| GHS precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Personal protective equipment (PPE) | Eyeshields, Gloves, type N95 (US) |
| Safety statements (S) | 22-24/25 |
| Water hazard class (WGK) | 3 |
| Storage class | 11 - Combustible Solids |
Safety & Regulations
| Personal protective equipment (PPE) | Eyeshields, Gloves, type N95 (US) |
|---|---|
| Water hazard class (WGK) | 3 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Safety statements (S) | 22-24/25 |
| Storage class | 11 - Combustible Solids |
| GHS hazard statements | H315-H319-H335 |
| GHS precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
Applications & Uses
Uses
P2X and P2Y purinergic receptors are ATP-sensitive receptors responsible for mediating a large variety of excitatory postsynaptic responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macrophage activation, and apoptosis. PPADS is a non-selective P2 purinergic antagonist that blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors. PPADS antagonism of ATP-sensitive P2 receptors produces neuroprotective effects in an ischemia model with permanent middle cerebral artery occlusion in spontaneously hypertensive rats.
Uses
PPADS Tetrasodium is an non-selective purinergic antagonists of P2 ATP receptors. PPADS Tetrasodium is also a potential neuroprotective agents for the treatment of autoimmune and demyelinating disease.