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Basic information
- Standard SMILES
C#CCC[C@H](N)C(=O)O.Cl- InChIKey
XGBWOGGSQVMSRX-JEDNCBNOSA-N- Molecular formula
- C6H10ClNO2
- Average molar mass
- 163.6 g/mol
Names & identifiers
- Preferred name
- L-Homopropargylglycine (HPG)
- English name
- L-Homopropargylglycine (HPG)
- Molecular formula
- C6H10ClNO2
- Molecular weight
- 163.6
Names & synonyms
Database identifiers
- CAS
942518-19-6- PubChem CID
- 136212900
- EC Number
- 111-020-5、832-354-4
Properties
Physicochemical properties
- solubility
- 125 mg/mL · DMSO : 125 mg/mL (764.06 mM; Need ultrasonic), ≤10mg/ml in PBS(pH7.2)
- form
- A crystalline solid
- color
- White to off-white
- Appearance
- off-white solid
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 335 · H335-H319-H315
- Precautionary statements
- 264 · P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Safety & regulation
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H335-H319-H315
- Precautionary statements
- P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Chemistry & industry
Applications
DescriptionL-Homopropargyl glycine is a reactive methionine analog that contains an alkyne moiety. It is readily inserted into newly-synthesized proteins in place of methionine. L-Homopropargyl glycine can then be labeled or captured through click chemistry. This approach represents a fast, sensitive, and non-radioactive alternative to [35S]-methionine for the detection of nascent protein synthesis.
UsesL-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor[1][2].
Suppliers18 total
Related reactions
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Linked notes
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