Sodium Glycerophosphate

HCID 14754CAS 1300-25-0

Basic information

Standard SMILES
O=P([O-])([O-])OCC(O)CO.[Na+].[Na+]
InChIKey
GEKBIENFFVFKRG-UHFFFAOYSA-L
Molecular formula
C3H7Na2O6P
Average molar mass
216.04 g/mol
Monoisotopic mass
215.97756313

Overview

Sodium glycerophosphate is one of several glycerophosphate salts. It is used clinically to treat or prevent low phosphate levels. Glycerophosphate is hydrolyzed to inorganic phosphate and glycerol in the body. The extent of this reaction is dependent on the activity of serum alkaline phosphatases.

Names & identifiers

Preferred name
Sodium Glycerophosphate
IUPAC
disodium;2,3-dihydroxypropyl phosphate
English name
Sodium b-Glycerophosphate Hydrate
Molecular formula
C3H7Na2O6P
Molecular weight
216.037381

Names & synonyms

SODIUM GLYCEROPHOSPHATESodium glycerophosphate hydrate1,2,3-Propanetriol, mono(dihydrogen phosphate), disodium salt, hydrateRefChem:886696241-577-055073-41-1RCS9EQ01V41555-56-2Sodium 1-glycerophosphate1334-74-3Disodium alpha-glycerophosphatealpha-Glycerophosphoric Acid Disodium Salt
Show more names
Sodium b-Glycerophosphate Hydrate
disodium;2,3-dihydroxypropyl phosphateSodium 2,3-dihydroxypropyl phosphateDisodium glycerol phosphate1300-25-0disodium 2,3-dihydroxypropyl phosphateSodium glycerophosphate anhydrousdisodium |A-glycerophosphate1,2,3-Propanetriol, 1-(dihydrogen phosphate), disodium salt

Database identifiers

CAS
1300-25-0、1334-74-3、1555-56-2、17603-42-8、55073-41-1
PubChem CID
14754
DTXSID
DTXSID801014666
ChEMBL
CHEMBL6067979
UNII
G43E72677U
EC Number
215-613-0、216-304-3、241-577-0
Nikkaji
J8.671A

Properties

Computed structural properties

Topological polar surface area
113 Ų
Hydrogen bond donors
2
Hydrogen bond acceptors
6
Rotatable bonds
3
Heavy atoms
12

Experimental & physicochemical properties

PolymersOther Classes -> Alcohols and Polyols, Other
CosmeticsOral care; Buffering; Antiplaque; Emulsifying
SolubilitySoluble
Human Drugs · 2 items

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Physical DescriptionSolid; [Sigma-Aldrich MSDS]

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 100% (54 of 54) of all reports.

Not Classified

Aggregated GHS information provided per 54 reports by companies from 1 notifications to the ECHA C&L Inventory.

This chemical does not meet GHS hazard criteria for 100% (48 of 48) of all reports.

Not Classified

Aggregated GHS information provided per 48 reports by companies from 1 notifications to the ECHA C&L Inventory.

Hazard information

Regulatory Information · 5 items

Chemical: 1,2,3-Propanetriol, 1-(dihydrogen phosphate), disodium salt

Chemical: 1,2,3-Propanetriol, 1-(dihydrogen phosphate), sodium salt

Disodium glycerol phosphate: Does not have an individual approval but may be used under an appropriate group standard

1,2,3-Propanetriol, 1-(dihydrogen phosphate), disodium salt: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Sodium glycerophosphate, hydrate: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS] See Glycerin.
Hazard Classes and Categories · 3 items

Not Classified

Not Classified

Not Classified

Chemistry & industry

Pharmacology

ATC Code · 2 items

B - Blood and blood forming organs

QB - Blood and blood forming organs

PharmacodynamicsGlycerophosphate acts as a source of inorganic phosphate through hydrolysis.
Mechanism of ActionSodium glycerophosphate acts as a donor of inorganic phosphate. See [DB09413] for a description of phosphate's role in the body.
Biological Half-LifeInorganic phosphate has a half-life of elimination of 2.06h.
Metabolism/MetabolitesGlycerophosphate is hydrolyzed to form inorganic phosphate. The extent of this reaction is dependent on serum alkaline phosphatase activity.
Absorption, Distribution and Excretion · 2 items

Peak serum phosphate concentration is reached in 4h.

Inorganic phosphate produced is eliminated in the urine. There may be a very small amount of glycerophosphate excreted in the urine unchanged.

Uses & manufacturing

Use ClassificationCosmetics -> Oral care; Buffering; Antiplaque; Emulsifying
General Manufacturing Information · 3 items

1,2,3-Propanetriol, mono(dihydrogen phosphate), sodium salt (1:2): ACTIVE

1,2,3-Propanetriol, 1-(dihydrogen phosphate), sodium salt (1:2): ACTIVE

1,2,3-Propanetriol, 1-(dihydrogen phosphate), sodium salt (1:?): ACTIVE

Suppliers1 total

HONEST JOY HOLDINGS LIMITED[email protected]

Related reactions

0 records

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Linked notes

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