Mavatrep

HCID 17751090CAS 956274-94-5

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Basic information

Standard SMILES
CC(C)(O)c1ccccc1-c1ccc2nc(/C=C/c3ccc(C(F)(F)F)cc3)[nH]c2c1
InChIKey
ORDHXXHTBUZRCN-NTEUORMPSA-N
Molecular formula
C25H21F3N2O
Average molar mass
422.45 g/mol
Monoisotopic mass
422.16059795

Names & identifiers

Preferred name
Mavatrep
IUPAC
2-[2-(2-{(E)-2-[4-(Trifluoromethyl)phenyl]ethenyl}-1H-benzimidazol-6-yl)phenyl]propan-2-ol
English name
mavatrep
Molecular formula
C25H21F3N2O
Molecular weight
422.45

Names & synonyms

CS-1660mavatrepMavatrep(JNJ-39439335)Mavatrep, 10 mM in DMSOJNJ 39439335JNJ39439335(E)-2-(2-(2-(4-(Trifluoromethyl)styryl)-1H-benzo[d]imidazol-6-yl)phenyl)propan-2-ol(trans)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzimidazol-5-yl}phenyl)propan-2-olBenzenemethanol, α,α-dimethyl-2-[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1H-benzimidazol-6-yl]-JNJ39439335,Inhibitor,capsaicin,JNJ 39439335,TRP Channel,neuropathic pain,calcium ions,Mavatrep,inhibit,Transient receptor potential channels,hTRPV1 channel,HEK293

Database identifiers

CAS
956274-94-5
PubChem CID
17751090
DTXSID
DTXSID90241905
ChEMBL
CHEMBL2364618
UNII
F197218T99
Nikkaji
J3.561.747G

Properties

Physicochemical properties

Boiling point
612.1 · 612.1±65.0 °C(Predicted)
Density
1.3 · 1.300±0.06 g/cm3(Predicted)
storage temp.
-20 °C · Store at -20°C
solubility
Soluble in DMSO
form
Powder
pka
10.73 · 10.73±0.10(Predicted)

Chemistry & industry

Applications · 1 item

UsesMavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain[1].

Upstream & downstream products

Suppliers35 total

上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
南通菡芳生物科技有限公司[email protected] 18017580634 · [email protected]
江苏艾康生物医药研发有限公司025-5885952 15955137747 · [email protected]
United Life Science020-82099279 18988941402 · [email protected]
InvivoChem中国13549236410 · [email protected]

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