| GHS classification | DangerH302 (92.9%): Harmful if swallowed [Warning Acute toxicity, oral]P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 42 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
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| Regulatory information | Hazard Traits - Carcinogenicity |
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| Hazards summary | Causes burnsInhalation may cause corrosive injuries to upper respiratory tractHarmful by ingestion, inhalation, and skin absorption[Sigma-Aldrich MSDS] See Dichloroacetic acid. |
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| Special Reports | Environmental Health Criteria 216: Disinfectants and DIsinfectant By-Products (1999) by the International Programme on Chemical Safety (IPCS) under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization. Available at http://www.inchem.org/documents/ehc/ehc/ehc216.htm as of August 1, 2008DHHS/NTPToxicology and Carcinogenesis Studies of Toxicology and Carcinogenesis Studies of Dibromoacetic Acid (CAS No. 631-64-1) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 326 pp. (2007) Technical Rpt Series No. 537 NIH Pub No.07-4475 |
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| Hazard Classes and Categories | Acute Tox. 4 (92.9%) |
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| Federal Drinking Water Standards | The maximum contaminant level for haloacetic acids (five) (HAA5) is 0.060 mg/L. /Haloacetic acids (five) (HAA5) mean the sum of the concentrations in milligrams per liter of the haloacetic acid compounds (monochloroacetic acid, dichloroacetic acid, trichloroacetic acid, monobromoacetic acid, and dibromoacetic acid), rounded to two significant figures after addition./ |
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| Firefighting Hazards | Emits toxic fumes under fire conditions. |
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| Fire fighting procedures | FIREFIGHTING. Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.EXTINGUISHING MEDIA . Carbon dioxide, dry chemical powder, or appropriate foam. |
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| Storage conditions | Keep tightly closed. |
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| Cleanup methods | Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. |
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| Disposal methods | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.Contact a licensed professional waste disposal service to dispose of this material. ... Observe all federal, state, and local environmental regulations. |
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| Preventive Measures | Avoid breathing dust. Do not get in eyes, on skin, on clothing. Avoid prolonged or repeated exposure.Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves. In case of leak or spill, evacuate the area.Wash contaminated clothing before reuse. Discard contaminated shoes. Wash thoroughly after handling.SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.For more Preventive Measures (Complete) data for DIBROMOACETIC ACID (7 total), please visit the HSDB record page. |
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| Personal Protective Equipment (PPE) | ENGINEERING CONTROLS. Safety shower and eye bath. Use only in a chemical fume hood.PERSONAL PROTECTIVE EQUIPMENT. Respiratory: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator.Hand: Compatible chemical-resistant gloves. Eye: Chemical safety goggles. Other: Faceshield (8-inch minimum). |
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| Interactions | The disinfection by-product dibromoacetic acid (DBA) has been found in female rats to increase circulating concentrations of both estradiol (E2) and estrone (E1). This effect is apparently due, at least in part, to a suppression in hepatic catabolism. The present study investigated whether DBA, by increasing sex steroid levels, is able either to augment the hypothalamic up-regulation involved in triggering a luteinizing hormone (LH) surge, or to affect the ability of the neurotoxicant sodium dimethyldithiocarbamate (DMDC) to block the surge. Sprague-Dawley rats were gavaged for 14 days with DBA (0-150 mg/kg) and ovariectomized on dosing day 11, and at the same time implanted with an estradiol capsule to generate daily LH surges. An injection of 0.1 mM/kg DMDC was administered at 13:00 hr on day 14 and blood was sampled over the afternoon. DBA induced a dose-related increase in total estrogens. For identified surges, areas under the LH curve partitioned into two groups, comprising the two lower (0 and 37.5 mg/kg DBA) and the two higher (75 and 150 mg/kg) treatment groups. Consequently, low and high DBA groups were compared and found to be significantly different. At 150 mg DBA/0.1 mM DMDC, the timing of an identifiable LH peak was comparable to non-DMDC females, unlike the 37.5mg DBA/0.1 mM DMDC group in which the appearance of peak concentrations was delayed. A significant effect with DBA treatment alone was not present. Results indicated that this exposure to DBA induced a dose-related increase in total estrogen concentrations that paralleled a diminished DMDC blockade of the LH surge. The effect appeared to be attributable to an augmentation in the estrogen-associated up-regulation in brain mechanisms stimulating the surge.Chlorination of drinking water generates disinfection by-products (DBPs) , which have been shown to disrupt spermatogenesis in rodents at high doses, suggesting that DBPs could pose a reproductive risk to men. ... A cohort study /was conducted/ to evaluate semen quality in men with well-characterized exposures to DBPs. ... The results of the present study do not support an association between exposure to DBPs at levels approaching regulatory limits and adverse sperm outcomes, although /there was/ an association between total organohalides and sperm concentration. ... The lone association of total organohalide exposure with sperm concentration may lend support to findings that have suggested that total organohalide is a stronger risk factor for adverse pregnancy outcomes than any of the regulated DBP groups or species and that the toxicity of total organohalides is greater than that of the individual or subclasses of DBPs. ... /Disinfection by-products/ |
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| Ecotoxicity values | LC50Species: Pimephales promelas (Fathead minnow, standard length 23.0 mm, weight 220 mg)Conditions: freshwater, static, 17.1-17.5 °C, pH 7.6-8.2, hardness 98-113 mg/L CaCO3, alkalinity 75-87 mg/L CaCO3, conductivity 143-178 umhos/cm, dissolved oxygen 6.4-8.8 mg/LConcentration: 160000 ug/L for 24 hr (95% confidence interval: 138000-1380000 ug/L) /98.9% purity/Concentration: 107000 ug/L for 48 hr (95% confidence interval: 99000-119000 ug/L) /98.9% purity/Concentration: 81000 ug/L for 72 hr (95% confidence interval: 73000-91000 ug/L) /98.9% purity/Concentration: 69000 ug/L for 96 hr (95% confidence interval: 62000-75000 ug/L) /98.9% purity/ |
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| Environmental fate | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1.5(SRC), determined from a water solubility of 2.11X10+6 mg/L(2) and a regression-derived equation(3), indicates that dibromoacetic acid is expected to have very high mobility in soil(SRC). The pKa of dibromoacetic acid is 1.48(4), indicating that this compound will primarily exist in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of dibromoacetic acid from moist soil surfaces is not expected to be an important fate process(SRC) given the compound's pKa(4). Dibromoacetic acid is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.3X10-2 mm Hg(SRC), determined from a fragment constant method(6). Limited data are available regarding the biodegradation of dibromoacetic acid in soil. However, dibromoacetic acid (5 mM) was used as a carbon source by Xanthobacter autotrophicus GJ10 as measured by halide production after a period of 10 days at 30 °C(7).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1.5(SRC), determined from a water solubility of 2.11X10+6 mg/L(2) and a regression-derived equation(3), indicates that dibromoacetic acid is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 1.48(4) indicates dibromoacetic acid will exist almost entirely in the anion form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(5). According to a classification scheme(6), an estimated BCF of 0.17(SRC), from its water solubility(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Limited data are available regarding the biodegradation of dibromoacetic acid in water. However, dibromoacetic acid (5 mM) was used as a carbon source by Xanthobacter autotrophicus GJ10 as measured by halide production after a period of 10 days at 30 °C(8).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dibromoacetic acid, which has an estimated vapor pressure of 2.3X10-2 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase dibromoacetic acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 25.3 days(SRC), calculated from its rate constant of 6.3X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Dibromoacetic acid does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). |
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| Adverse effects | Dermatotoxin - Skin burns. |
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| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=631-64-1] |
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| Effluent Concentrations | Dibromoacetic acid was detected in the Tres Rios Wetlands, which receive tertiary-treated sewage effluent from the 91st Ave Wastewater Treatment Plant southwest of Phoenix, AZ, at concentrations of not detected-0.4 ug/L(1). |
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| Soil Adsorption/Mobility | The Koc of dibromoacetic acid is estimated as 1.5(SRC), using a water solubility of 2.11X10+6 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that dibromoacetic acid is expected to have very high mobility in soil. The pKa of dibromoacetic acid is 1.48(4), indicating that this compound will primarily exist in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). |
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| Atmospheric Concentrations | SOURCE DOMINATED: Dibromoacetic acid was qualitatively identified as a component of smokestack emissions from a municipal incinerator in Boras, Sweden(1). |
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| Human Toxicity Excerpts | /SIGNS AND SYMPTOMS/ Skin Contact: Causes burns. Skin Absorption: Harmful if absorbed through skin. Eye Contact: Causes burns. Inhalation: Material is extremely destructive to the tissue of the mucous membranes and upper respiratory tract. Harmful if inhaled. Ingestion: Harmful if swallowed./SIGNS AND SYMPTOMS/ Inhalation may result in spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin. Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting./EPIDEMIOLOGY STUDIES/ Chlorination of drinking water generates disinfection by-products (DBPs) , which have been shown to disrupt spermatogenesis in rodents at high doses, suggesting that DBPs could pose a reproductive risk to men. ...This study ...assessed DBP exposure and testicular toxicity, as evidenced by altered semen quality. ... A cohort study /was conducted/ to evaluate semen quality in men with well-characterized exposures to DBPs. Participants were 228 presumed fertile men with different DBP profiles. They completed a telephone interview about demographics, health history, water consumption, and other exposures and provided a semen sample. Semen outcomes included sperm concentration and morphology, as well as DNA integrity and chromatin maturity. Exposures to DBPs were evaluated by incorporating data on water consumption and bathing and showering with concentrations measured in tap water. ... Multivariable linear regression /was used/ to assess the relationship between exposure to DBPs and adverse sperm outcomes. ... The mean (median) sperm concentration and sperm count were 114.2 (90.5) million/mL and 362 (265) million, respectively. The mean (median) of the four trihalomethane species (THM4) exposure was 45.7 (65.3) ug/L, and the mean (median) of the nine haloacetic acid species (HAA9) exposure was 30.7 (44.2) ug/L. These sperm parameters were not associated with exposure to these classes of DBPs. For other sperm outcomes, we found no consistent pattern of increased abnormal semen quality with elevated exposure to trihalomethanes (THMs) or haloacetic acids (HAAs) . The use of alternate methods for assessing exposure to DBPs and site-specific analyses did not change these results. ... Overall, the results of the present study do not support an association between exposure to DBPs at levels approaching regulatory limits and adverse sperm outcomes, although /there was/ an association between total organohalides and sperm concentration that was in line with /the/ hypothesis.... The lone association of total organohalide exposure with sperm concentration may lend support to findings that have suggested that total organohalide is a stronger risk factor for adverse pregnancy outcomes than any of the regulated DBP groups or species... and that the toxicity of total organohalides is greater than that of the individual or subclasses of DBPs. ... Previous studies have suggested that exposures to THMs via bathing and showering may be more strongly associated with adverse reproductive outcomes than other exposure indicators... /These/ results did not support these findings. /Disinfection by-products//EPIDEMIOLOGY STUDIES/ ... A retrospective cohort study /was conducted/ to examine the effects of exposure to THMs and HAAs during the third trimester and during individual weeks and months of late gestation on the risks for term low birth weight, intrauterine growth retardation, and very preterm and preterm births. The study population (n = 48,119) included all live births and fetal deaths occurring from January 1998 through March 2003 to women whose residence was served by one of three community water treatment facilities. ... Evidence /was found/ of associations between exposure to specific HAAs and term low birth weight as well as intrauterine growth retardation and for exposure to the five regulated HAAs (HAA5) and term low birth weight. /These/ findings suggest a critical window of exposure with respect to fetal development during weeks 33-40 for the effects of dibromoacetic acid and during weeks 37-40 for the effects of dichloroacetic acid. Adjustment for potential confounders did not affect the conclusions. |
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| Artificial Pollution Sources | Dibromoacetic acid's formation as a chemical byproduct of chlorination and chloramination of drinking water(1) may result in its release to the environment through various waste streams. |
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| Environmental Biodegradation | AEROBIC: Limited data are available regarding the biodegradation of dibromoacetic acid. However, dibromoacetic acid (5 mM) was used as a carbon source by Xanthobacter autotrophicus GJ10 as measured by halide production after a period of 10 days at 30 °C(1). |
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| Carcinogen Classification | Dibromoacetic acidGroup 2B: Possibly carcinogenic to humansVolume 101: (2012) Some Chemicals Present in Industrial and Consumer Products, Food and Drinking-water20132011 |
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