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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 21885Generated: October 23, 2026

2-Dimethylaminopyridine

N,N-dimethylpyridin-2-amine · 2-(N,N-dimethylamino)pyridine · 2-Dimethylaminopyridin · 2-DIMETHYLAMINOPYRIDINE · 2-dimethylamino-pyridin · dimethylamino-2pyridine · (2-Pyridinyl)dimethylamine · (Dimethylamino)-2-pyridine

https://huagongshe.com/en/chemical/21885

2-Dimethylaminopyridine molecular structure

Identifiers & Physical Properties

CAS No.5683-33-0
Molecular formulaC7H10N2
Average molar mass122.17 g/mol
Monoisotopic mass122.08439832 g/mol
SMILESCN(C)c1ccccn1
InChIKeyPSHKMPUSSFXUIA-UHFFFAOYSA-N
PubChem CID21885
EC No.227-147-5
DTXSIDDTXSID9022231

Chemical & Physical Properties

XLogP1.6
Topological polar surface area16.1
Hydrogen bond donors0
Hydrogen bond acceptors2
Rotatable bonds1
Heavy atoms9
Formal charge0
Complexity81
SpringerMaterials Properties15N nuclear magnetic resonance spectrum
Melting point182°C
Boiling point191 °C(lit.)
Density0.984 g/mL at 25 °C(lit.)
Refractive indexn20/D 1.559(lit.)
Flash point167 °F
Storage conditionsStore below +30°C.
pKa (acidity coefficient)7.04±0.10(Predicted)
Physical stateLiquid
ColorClear colorless to pale yellow
SolubilitySoluble in water.
BRN110353
InChIInChI=1S/C7H10N2/c1-9(2)7-5-3-4-6-8-7/h3-6H,1-2H3
InChIKeyPSHKMPUSSFXUIA-UHFFFAOYSA-N
SMILESC1(N(C)C)=NC=CC=C1
CAS DataBase Reference5683-33-0(CAS DataBase Reference)
FDA UNII18Q95U3Z8H
NIST Chemistry ReferenceN,N-Dimethyl-2-pyridinamine(5683-33-0)
UNSPSC Code12352100
NACRESNA.22
GHS pictogramGHS02,GHS07
Signal wordWarning
GHS hazard statementsH226-H315-H319-H335
GHS precautionary statementsP210-P233-P240-P241-P303+P361+P353-P305+P351+P338
Target organsRespiratory system
Personal protective equipment (PPE)Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard symbolsXi,T
Risk statements (R)36/37/38-34-23/24/25
Safety statements (S)23-26-36-45-36/37/39-27
UN transport number1993
Water hazard class (WGK)3
RTECS numberUS9200000
F10
Hazard class3Eye Irrit. 2Flam. Liq. 3Skin Irrit. 2STOT SE 3
Packing groupII
Customs code29333999
Storage class3 - Flammable liquids

Safety & Regulations

GHS classificationWarningH302 (10.9%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 46 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Regulatory information2-(Dimethylamino)pyridine: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesAcute Tox. 4 (10.9%)
F10
Personal protective equipment (PPE)Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Water hazard class (WGK)3
RTECS numberUS9200000
UN transport number1993
Customs code29333999
Risk statements (R)36/37/38-34-23/24/25
Signal wordWarning
GHS pictogramGHS02,GHS07
Hazard symbolsXi,T
Safety statements (S)23-26-36-45-36/37/39-27
Hazard class3Eye Irrit. 2Flam. Liq. 3Skin Irrit. 2STOT SE 3
Storage class3 - Flammable liquids
Packing groupII
Target organsRespiratory system
GHS hazard statementsH226-H315-H319-H335
GHS precautionary statementsP210-P233-P240-P241-P303+P361+P353-P305+P351+P338

Applications & Uses

Uses

2-(Dimethylamino)pyridine in toluene at room temperature in the presence of 1.1 equivalent of methyl trifluoromethanesulfonate forms (2-pyridyl)-trimethylammonium trifluoromethanesulfonate salt. It is used as a model substrate in the preparation of chelate carbene via cyclometalation, H2 loss and reversible α-elimination.

General Description

2-(Dimethylamino)pyridine is a clear, colorless to light yellow liquid.