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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 2734217Generated: October 23, 2026

2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl

DAVEPHOS · 2-(DICYCLOHEXYLPHOSPHINO)-2'-(DIMETHYLAMINO)BIPHENYL · N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-diMethylaMine · 2-(N,N-Dimethylamino)-2-(dicyclohexylphosphino)biphenyl · 2'-(dicyclohexylphosphino)-N,N-diMethyl-[1,1'-biphenyl]-2-aMine · DavePhos 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl · 2'-(dicyclohexylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine · Davep

https://huagongshe.com/en/chemical/2734217

2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl molecular structure

Identifiers & Physical Properties

CAS No.213697-53-1
Molecular formulaC26H36NP
Average molar mass393.5 g/mol
Monoisotopic mass393.25853678 g/mol
SMILESCN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1
InChIKeyZEMZPXWZVTUONV-UHFFFAOYSA-N
PubChem CID2734217
EC No.606-749-5
DTXSIDDTXSID20370171

Chemical & Physical Properties

XLogP6.9
Topological polar surface area3.2
Hydrogen bond donors0
Hydrogen bond acceptors1
Rotatable bonds5
Heavy atoms28
Formal charge0
Complexity433
Melting point121-124 °C(lit.)
Boiling point539.6±43.0 °C(Predicted)
Storage conditionsKeep in dark place,Sealed in dry,Room Temperature
pKa (acidity coefficient)5.04±0.18(Predicted)
Physical statecrystal
Colorwhite
SolubilityInsoluble
SensitivityAir Sensitive
InChIInChI=1S/C26H36NP/c1-27(2)25-19-11-9-17-23(25)24-18-10-12-20-26(24)28(21-13-5-3-6-14-21)22-15-7-4-8-16-22/h9-12,17-22H,3-8,13-16H2,1-2H3
InChIKeyZEMZPXWZVTUONV-UHFFFAOYSA-N
SMILESC1(C2=CC=CC=C2P(C2CCCCC2)C2CCCCC2)=CC=CC=C1N(C)C
CAS DataBase Reference213697-53-1(CAS DataBase Reference)
FDA UNII9877ONU78F
UNSPSC Code12352116
NACRESNA.22
GHS pictogramGHS07
Signal wordWarning
GHS hazard statementsH315-H319-H335
GHS precautionary statementsP264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338
Personal protective equipment (PPE)dust mask type N95 (US), Eyeshields, Gloves
Hazard symbolsXi,Xn
Risk statements (R)36/37/38-22
Safety statements (S)26-36/37/39
Water hazard class (WGK)3
TSCA inventory statusNo
Hazard classAIR SENSITIVE
Customs code29310099
Storage class11 - Combustible Solids

Safety & Regulations

GHS classificationWarningH315 (98.9%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 87 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard Classes and CategoriesSkin Irrit. 2 (98.9%)
Personal protective equipment (PPE)dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK)3
TSCA inventory statusNo
Customs code29310099
Risk statements (R)36/37/38-22
Signal wordWarning
GHS pictogramGHS07
Hazard symbolsXi,Xn
Safety statements (S)26-36/37/39
Hazard classAIR SENSITIVE
Storage class11 - Combustible Solids
GHS hazard statementsH315-H319-H335
GHS precautionary statementsP264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338

Applications & Uses

Description

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl is a potent inhibitor of the enzyme bromodomain. Bromodomain has been implicated in cancer and other diseases. It binds to the bromodomain in a covalent manner, blocking the ATP site and inhibiting bromodomain function. This inhibition has been shown to be selective for bromodomains over other domains.

Uses

suzuki reaction

Uses

Effective ligand in the Pd-catalyzed arylation of ester enolates

Uses

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl can act as ligand used in the palladium-catalyzed Suzuki coupling and amination of unactivated aryl chlorides.