2-Amino-N-methylbenzamide (HCID 308072)

Overview

N-Methylanthranilamide is an aminobenzoic acid.

Names & identifiers

Preferred name: 2-Amino-N-methylbenzamide
IUPAC: 2-amino-N-methylbenzamide
English name: 2-Amino-N-methylbenzamide
Molecular formula: C8H10N2O
Molecular weight: 150.18

Names & synonyms

2-Amino-N-methylbenzamide4141-08-6DTXSID30308703RefChem:465058DTXCID50259829673-048-92-Amino-N-Methyl-BenzamideN-Methyl 2-aminobenzamideN-MethylanthranilamideMFCD00060602benzamide, 2-amino-n-methyl-2-Aminobenzoylmethylamide

Show more names

NSC 207861BUTTPARK 34\02-072-Amino-n-methybenzamideo-AMino-N-MethylbenzaMideN-Methyl-2-aMinobenzaMide2-(Methylcarbamoyl)anilineAnthranilic Acid MethylaMide

Oprea1_113871Benzamide, o-amino-N-methyl-NSC207861CS-W004940NSC-207861AC-4392EN300-17933C17512

Database identifiers

CAS: 4141-08-6
PubChem CID: 308072
DTXSID: DTXSID30308703
ChEBI: CHEBI:81147
EC Number: 673-048-9
Nikkaji: J1.374.332K

Properties

Computed structural properties

XLogP: 0.6
Topological polar surface area: 55.1 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 2
Rotatable bonds: 1
Heavy atoms: 11
Formal charge: 0
Complexity: 147

Physicochemical properties

Melting point: 75 °C · 75 °C
Boiling point: 346.7 · 346.7±25.0 °C(Predicted)
Density: 1.137 · 1.137±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO, Methanol
form: Solid
pka: 14.73 · 14.73±0.46(Predicted)
color: White
CAS DataBase Reference: 4141 · 4141-08-6(CAS DataBase Reference)
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 315 · H315-H319
Precautionary statements: 264 · P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38
Safety Statements: 26 · 26-36/37/39
HazardClass: IRRITANT
HS Code: 2924297099 · 2924297099

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 3 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

Safety data

hs_code: 2924297099
risk_code: 36/37/38
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi
safety_code: 26-36/37/39
hazard_class: IRRITANT
Hazard statements: H315-H319
Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Chemistry & industry

Applications · 2 items

Uses2-Amino-N-methylbenzamide is a plant safening agent selected from auxins, auxin precursors, metabolites or derivatives, and acetaminophen or a derivative. Safening examples are provided for fertilizer s, fungicides, insecticides, and herbicides.

General Description2-AMINO-N-METHYLBENZAMIDE is a key synthetic intermediate used to construct the core skeleton of FAK inhibitors (PA-DPPYs). It first reacts with 2,4,5-trichloropyrimidine (or 2,4-dichloro-5-nitropyrimidine) to form the 2-(2-chloro-5-substituted-pyrimidin-4-ylamino) -N-methylbenzamide intermediate, which is subsequently coupled with an aromatic amine containing a phosphate group to ultimately yield a series of bispyrimidine derivatives exhibiting anti-pancreatic cancer activity[6].