2-Amino-5-methylthiazole

HCID 351770CAS 7305-71-7
Substructure searchFind similar structures

Basic information

Standard SMILES
Cc1cnc(N)s1
InChIKey
GUABFMPMKJGSBQ-UHFFFAOYSA-N
Molecular formula
C4H6N2S
Average molar mass
114.17 g/mol
Monoisotopic mass
114.02516919

Overview

binds the W191G cavity of E coli cytochrome c peroxidase

Names & identifiers

Preferred name
2-Amino-5-methylthiazole
IUPAC
5-methyl-1,3-thiazol-2-amine
English name
2-Amino-5-methylthiazole
Molecular formula
C4H6N2S
Molecular weight
114.17

Names & synonyms

2-Amino-5-methylthiazole7305-71-75-Methyl-1,3-thiazol-2-amine2-Thiazolamine, 5-methyl-2-Amino-5-methyl-thiazole5-Methyl-2-aminothiazole5-METHYL-2-THIAZOLAMINE(5-Methylthiazol-2-yl)amine7RAB78AF2PNSC-523150DTXSID102233292a5mt cpd
Show more names
2,5-amthNSC 523150AKOS BBS-00006638BUTTPARK 18\10-87Meloxicam usp RC B2-Amino-5-methylthiaLABOTEST-BB LT000806452 mino-5-methylthiazole
RefChem:464648DTXCID60145820423-800-5615-902-55-methylthiazol-2-amineMeloxicam EP Impurity BMFCD00078317Thiazole, 2-amino-5-methyl-

Database identifiers

CAS
7305-71-7
PubChem CID
351770
DTXSID
DTXSID10223329
ChEMBL
CHEMBL502447
UNII
7RAB78AF2P
EC Number
423-800-5、615-902-5
Nikkaji
J382.938C

Properties

Computed structural properties

XLogP
1
Topological polar surface area
67.2 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
3
Rotatable bonds
0
Heavy atoms
7

Physicochemical properties

Melting point
93 · 93-98 °C (lit.)
Boiling point
232.5 · 232.5±9.0 °C(Predicted)
Density
1.258 · 1.258±0.06 g/cm3(Predicted)
vapor pressure
0.153 · 0.153-1.24Pa at 20-40℃
storage temp.
2 · 2-8°C
solubility
soluble in Methanol

Safety & regulation

GHS classification

GHS Classification · 6 items

Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]

P260, P264, P270, P273, P301+P317, P319, P330, P391, and P501 (click each P-code to see the statement)

Warning

H302 (96.4%): Harmful if swallowed [Warning Acute toxicity, oral]

P260, P264, P270, P273, P301+P317, P319, P330, P391, and P501 (click each P-code to see the statement)

Hazard information

Regulatory InformationStatus: Active Update: 17-10-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/25186
Hazard Classes and Categories · 4 items

Acute Tox. 4 (96.4%)

Acute Tox. 4 (100%)

Acute toxicity - category 4

Acute Tox. 4 *

Safety data

PPE
dust mask type N95 (US), Eyeshields, Gloves
wgk
3
ridadr
2811
hs_code
29341000
risk_code
22-48/22-50/53-36/37/38
Signal word
Warning

Chemistry & industry

Applications · 3 items

Uses2-Amino-5-methylthiazole may be used in the preparation of acrylamide monomer, 5-methyl-2-thiozyl methacrylamide (MTMAAm).

UsesAn aminothiazole derivative used in characterization and DNA-interaction studies via formation of metal complexes that bind competitively to DNA. 2-Amino-5-methylthiazole can be used in solar cells to influence the interaction with the TiO2 photoelectrode, which in turn alters the dye-sensitized solar cell performance.

General Description2-Amino-5-methylthiazole is a heterocyclic building block. It is one of the major alkaline metabolite of tenoxicam (TX) and meloxicam (MX).

Preparation methods · 1 item

PreparationUsing 1,2,3-trichloropropane as a starting material, it reacts with sodium hydroxide to produce 2,3-dichloro-1-propene, which then reacts with potassium thiocyanate and isomerizes to produce 2-chloro-2-propenyl isothiocyanate. This is then reacted with ammonia to give N-(2-chloro-2-propenyl)thiourea, which is subsequently cyclized in the presence of 80% sulfuric acid to give 2-amino-5-methylthiazole.

Upstream & downstream products

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

Related reactions

162 records
New reaction record

Linked notes

Loading…