(1R,2R)-2-(3,4-Difluorophenyl)cyclopropane-1-carboxamide

HCID 44185730CAS 1006376-62-0

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Basic information

Standard SMILES: NC(=O)[C@@H]1C[C@H]1c1ccc(F)c(F)c1
InChIKey: PYEJQVYISBUGDU-NKWVEPMBSA-N
Molecular formula: C10H9F2NO
Average molar mass: 197.184 g/mol
Monoisotopic mass: 197.06522035

Names & identifiers

Preferred name: (1R,2R)-2-(3,4-Difluorophenyl)cyclopropane-1-carboxamide
IUPAC: (1R,2R)-2-(3,4-Difluorophenyl)cyclopropane-1-carboxamide
English name: (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide
Molecular formula: C10H9F2NO
Molecular weight: 197.18

Names & synonyms

(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxamideCyclopropanecarboxamide, 2-(3,4-difluorophenyl)-, (1R,2R)-Ticagrelor (1R,2R)-Carboxamide(1R, 2R) -2- (3, 4-difluorophenyl) Carboxamide(1R, 2S) -2- (3,4-difluorophenyl) cyclopropamide(1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide(1R,2R)-2-(3,4-difluorophenyl)-1-cyclopropanecarboxamide(1R, 2R) -2- (3,4-difluorophenyl) cyclopropane formamide(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxamide - [D88526]

Database identifiers

CAS: 1006376-62-0
PubChem CID: 44185730
DTXSID: DTXSID30657804
UNII: NR7M7ZW2Y9
EC Number: 600-115-1
Nikkaji: J2.688.117J

Properties

Physicochemical properties

Melting point: 145 · 145 - 147°C
Boiling point: 347.9 · 347.9±42.0 °C(Predicted)
Density: 1.366 · 1.366±0.06 g/cm3(Predicted)
storage temp.: 2 · 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 16.43 · 16.43±0.40(Predicted)
color: White to Off-White
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 302 · H302-H315-H319-H335
Precautionary statements: 261 · P261-P305+P351+P338
HS Code: 2924297099 · 2924297099
REACH Registrations: Active

Safety & regulation

Safety data

hs_code: 2924297099
Signal word: Warning
Symbol(GHS): GHS07
Hazard statements: H302-H315-H319-H335
REACH Registrations: Active
Precautionary statements: P261-P305+P351+P338

Chemistry & industry

Applications

Uses(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide is a part of the synthetic preparation of the synthesis and inhibitory effect on ADP-induced platelet aggregation of ticagrelor derivatives as antiplatelets agents.

Upstream & downstream products

Upstream raw materials

Cyclopropanecarbonyl chloride, 2-(3,4-difluorophenyl)-, (1R,2R)-2-Chloro-1-(3,4-difluoro-phenyl)-ethanone (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbonitrile (1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid 1,2-Difluorobenzene

Suppliers50 total

天津始加生物医药科技有限公司15022261580 · [email protected]

南京凯美西化工有限公司02558748998 18951874644 · [email protected]

Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]

武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]

艾吉析科技（上海）有限公司17717235263 · [email protected]

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