HuagongsheHuagongshe Chemistry Print Report · For research reference only
Resveratrol
TRANS-RESVERATROL · Resveratrol Powder · TRANS-3,4,5-TRIHYDROXYSTILBENE · baililuchun · (E)-Resveratrol · Grape peel Extract · RESVERTROL · TRANS-3,5,4'-TRIHYDROXYSTILBENE
Identifiers & Physical Properties
| CAS No. | 501-36-0 |
|---|---|
| Molecular formula | C14H12O3 |
| Average molar mass | 228.24 g/mol |
| Monoisotopic mass | 228.07864424 g/mol |
| SMILES | Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 |
| InChIKey | LUKBXSAWLPMMSZ-OWOJBTEDSA-N |
| PubChem CID | 445154 |
| ChEMBL | CHEMBL165 |
| ChEBI | CHEBI:27881 |
| EC No. | 610-504-8 |
| DTXSID | DTXSID4031980 |
Chemical & Physical Properties
| XLogP | 3.1 |
|---|---|
| Topological polar surface area | 60.7 |
| Hydrogen bond donors | 3 |
| Hydrogen bond acceptors | 3 |
| Rotatable bonds | 2 |
| Heavy atoms | 17 |
| Formal charge | 0 |
| Complexity | 246 |
| Drugs | Pharmaceuticals -> Listed in ZINC15 |
| Lipids | Polyketides [PK] -> Aromatic polyketides [PK13] -> Diphenyl ethers, biphenyls, dibenzyls and stilbenes [PK1309] |
| LogP (partition coefficient) | log Kow = 3.102.56 |
| Color/Form | Off-white powder from methanol |
| Solubility | In water, 3 mg/100 mLSoluble in organic solvents such as ethanol, DMSO and dimethyl formamide at approximately 65 mg/mLsolubility in PBS (phosphate buffered saline) at pH 7.2 is approximately 100 ug/mLSoluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).Soluble in water (3 mg/100mL), ethanol (50 mg/mL), DMSO (16 mg/mL), DMF (~65 mg/mL), PBS (pH 7.2) (~100µg/mL), methanol, and acetone (50 mg/mL). |
| Dietary Ingredients | Resveratrol |
| Human Drugs | Breast FeedingLactationComplementary Therapies |
| Endocrine Disruptors | Potential endocrine disrupting compound |
| Decomposition | When heated to decomposition it emits acrid smoke and irritating vapors. |
| Melting point | 253-255 °CMP: 261 °C (decomposes)254 °C253-255°C |
| Physical Description | Solid |
| Collision Cross Section | 159.3 Ų [M-H]- [CCS Type: DTBuffer gas: N2Ionization: ESI-Dataset: TOXCASTSource Identifier: DTXSID4031980]152.09 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| Boiling point | 449.1±14.0 °C(Predicted) |
| Density | 1.359±0.06 g/cm3(Predicted) |
| Storage conditions | -20°C |
| pKa (acidity coefficient) | 9.22±0.10(Predicted) |
| Physical state | Powder |
| Color | Off-white |
| Biological source | plant root (bushy knotweed) |
| Merck | 14,8158 |
| Henry's law constant | 7.0×1010 mol/(m3Pa) at 25℃, HSDB (2015) |
| Stability | Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Cosmetics Ingredients Functions | SKIN PROTECTINGANTIOXIDANT |
| InChI | InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+ |
| InChIKey | LUKBXSAWLPMMSZ-OWOJBTEDSA-N |
| SMILES | C1(O)=CC(/C=C/C2=CC=C(O)C=C2)=CC(O)=C1 |
| LogP (partition coefficient) | 3.139 (est) |
| CAS DataBase Reference | 501-36-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | resveratrol |
| FDA UNII | Q369O8926L |
| NCI Drug Dictionary | resveratrol |
| EPA Substance Registry System | 1,3-Benzenediol, 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]- (501-36-0) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H319 |
| GHS precautionary statements | P264-P280-P305+P351+P338-P337+P313 |
| Hazard symbols | Xi |
| Risk statements (R) | 37/38-41-36/38-36-43-22 |
| Safety statements (S) | 26-39-37/39-36/37/39 |
| Water hazard class (WGK) | 3 |
| RTECS number | CZ8987000 |
| Customs code | 29072990 |
| Storage class | 11 - Combustible Solids |
| Hazard class | Eye Irrit. 2 |
| Hazardous substances data | 501-36-0(Hazardous Substances Data) |
| REACH registrations | Inactive |
Safety & Regulations
| GHS classification | This chemical does not meet GHS hazard criteria for 0.6% (1 of 160) of reports.DangerH315 (13.8%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 160 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatory information | Regulation (EC) No 258/1997Resveratrol: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| Special Reports | Athar M et alResveratrol: A Review of Pre-clinical Studies for Human Cancer PreventionToxicol Appl Pharmacol 224(3): 274-283 (2007). A review with 117 references.[Available from, as of August 20, 2014: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2083123] |
| History and Incidents | Resveratrol as well as the other polyphenols in wine, is thought to account in large part for so-called French Paradox. The French Paradox - the finding that the rate of coronary heart disease mortality in France is lower than observed in other industrialized countries with a similar risk factor profile - has been attributed to frequent consumption of red wine. |
| Hazard Classes and Categories | Skin Irrit. 2 (13.8%) |
| Disposal methods | SRP: Criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
| Interactions | ... /Resveratrol exhibited/ dose-dependent inhibition of the mutagenic response induced by treatment of Salmonella typhimurium strain TM 677 with 7,12-dimethyl-benzanthracene (DMBA) ...... Resveratrol ... enhanced the anti-tumor effect of 5-FU ...In neuronal-like cells, such as the human neuroblastoma SH-SY5Y resveratrol was shown to inhibit caspase 7 activation, as well as degradation of poly-(ADP-ribose)-polymerase, which occur in cells exposed to paclitaxel, an anti-cancer drug ... Resveratrol was shown to induce S-phase arrest, preventing SH-SY5Y from entering mitosis, the phase of the cell cycle in which paclitaxel exerts its activity ... Phosphorylation of Bcl-2 and JNK/SAPK, which specifically occurs after paclitaxel exposure, was reversed by resveratrol ...The combined effects of resveratrol have been tested with Ara-C or tiazofurin, both antimetabolites, and showed synergistic growth inhibition and apoptosis induction in HL-60 cells ...For more Interactions (Complete) data for RESVERATROL (22 total), please visit the HSDB record page. |
| Hepatotoxicity | There have been multiple trials of resveratrol in human subjects, but the dose regimen and duration of therapy has varied greatly and many trials lacked information on adverse events, ALT elevations, and hepatotoxicity. Nevertheless, in most studies there was no mention of serum ALT elevations or only rare and mild-to-moderate increases that were asymptomatic and resolved rapidly upon stopping therapy. However, in studies using high doses of resveratrol (1.5 to 3.0 grams daily), average serum ALT and AST levels rose slightly during therapy and promptly fell into the normal range with stopping. There were, however, no instances of serum ALT elevations with jaundice or symptoms. Furthermore, despite widespread clinical use, there have been no published reports of clinically apparent liver injury attributed to resveratrol. In large case series and nationwide registries on herbal induced liver injury, resveratrol is not listed as a cause. Thus, hepatotoxicity due to resveratrol must be rare, if it occurs at all. |
| Environmental fate | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 3.5X10+4(SRC), determined from a structure estimation method(2), indicates that resveratrol is expected to be immobile in soil(SRC). Resveratrol has estimated pKa values of 8.99, 9.63 and 10.64(3) indicating that this compound will exist primarily in the neutral form in the environment with the anion form partially existing in alkaline soils and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of resveratrol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.4X10-16 atm-cu m/mole(SRC), using a fragment constant estimation method(2). Resveratrol is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.2X10-9 mm Hg(SRC), determined from a fragment constant method(2). Resveratrol has UV absorption maxima at 307 and 321 nm(5) and, therefore, may be susceptible to direct photolysis on soil surfaces exposed to sunlight(SRC). Biodegradation data in soil were not available(SRC, 2014).[(1) Swann RL et alRes Rev 85: 17-28 (1983) (2) US EPAEstimation Program Interface (EPI) Suite. Ver. 4.11. Nov, 2012. Available from, as of Feb 11, 2014: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm (3) Royal Soc ChemChemSpider. 5-AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 3.5X10+4(SRC), determined from a structure estimation method(2), indicates that resveratrol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.4X10-16 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). According to a classification scheme(4), an estimated BCF of 50(SRC), from its log Kow of 3.10(5) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Resveratrol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). Resveratrol has UV absorption maxima at 307 and 321 nm(6) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). Resveratrol contains both phenol and olefin functions, and phenols and olefins are susceptible to photo-oxidation via peroxy, hydroxyl and singlet oxygen radicals in natural waters exposed to sunlight with combined half-lives on the order of one to three weeks at the water's surface(7). Biodegradation data in water were not available(SRC, 2014).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), resveratrol, which has an estimated vapor pressure of 1.2X10-9 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase resveratrol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 1.5 hours(SRC), calculated from its rate constant of 2.6X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Vapor-phase resveratrol is also degraded in the atmosphere by reaction with ozone(SRC)the half-life for this reaction in air is estimated to be 1.1 hours(SRC), calculated from its rate constant of 2.5X10-16 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase resveratrol may be removed from the air by wet and dry deposition(SRC). Resveratrol has UV absorption maxima at 307 and 321 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). |
| Food survey values | Concentrations of resveratrol in California varietal wines from the 1989 vintage year were: Napa Valley Cabernet Sauvignon, <0.05 to 0.09 mg/LNapa Valley Zinfandel, not detected to 0.11 mg/LCarneros Pinot Noir, 0.23 and 0.68 mg/LRussian River Pinot Noir, 0.21 mg/LSauternes white Bordeaux, <0.05 mg/LSanta Cruz Chardonnay (1990), not detected(1). The resveratrol concentration in hop cones has been observed to depend on harvest yearrepresentative varieties contained 0.32 to 1.00 mg/kg in 2004, 0.03 to 0.81 mg/kg in 2005, and 0.23 to 2.28 mg/kg in 2006(2). The resveratrol concentration in selected foods is as follows: 0.01-0.26 mg in 1 cup (146 g) raw peanuts0.32-1.28 mg in 1 cup (180 g) boiled peanuts0.04-0.13 mg in 1 cup (258 g) peanut butter0.24-1.25 mg in 1 cup (160 g) red grapes(3). Total resveratrol in a 5-oz glass of various red and white wines ranged from 0.01-0.27 mg in the white wines to 0.29-1.89 mg in red wines(3). Total resveratrol in Spanish red grape juices ranged from 1.14 to 8.69 mg/L(3). Total resveratrol in 1 cup cocoa powder (200 g) ranged from 0.28 to 0.46 mg(4). Normal consumption quantities of cocoa powder, baking chocolate, and dark chocolate contain low levels of resveratrol at 1.85, 1.24 and 0.35 mg/kg, respectively(4). Resveratrol is found in peanuts and berries of Vaccinum species, including blueberries, bilberries, and cranberries(3). Most resveratrol supplements available in the US contain extracts of the root of Polygonum cuspidatum, also known as Hu Zhang or kojo-kon(3).Measured resveratrol content of several representative commercial wines(1). [Table#7263]Red wine extracts and red grape extracts containing resveratrol and other polyphenols are also available in the US as dietary supplements. Resveratrol supplements may contain anywhere from 10-50 mg of resveratrol(1).Resveratrol has been measured in roasted peanuts at a concentration of 0.055 ug/g, in peanut butter at 0.324 ug/g, and in boiled peanuts at 5.138 ug/g(1). The Chinese medicinal herb Hu Zhang, a variety of Polygonium cuspidatum, was found to contain 3.77 mg/g dry weight resveratrol in the root(2). The concentration of resveratrol in red wine can vary from 0.2 to 5.8 mg/L depending upon grape variety(3). In peanuts before sprouting, resveratrol was detected in the range of 2.3 to 4.5 ug/g, and after sprouting, in the range of 11.7 to 25.7 ug/g depending upon peanut cultivar(4). The fruit of the mulberry /genus: Vaccinium/, especially the skin, is a source of resveratrol(5). Resveratrol was detected in grape, cranberry, and wine samples at concentrations ranging from 1.56 to 1042 nmol/g in Concord grape products, and from 8.63 to 24.84 mol/L in Italian red wine(6)the concentrations of resveratrol were similar in cranberry and grape juice at 1.07 and 1.56 nmol/g, respectively(6).Resveratrol was measured in pulp of the strawberry cultivar Fragaria x ananassa var. Allstar at a mean concentration of 830.5 ng/g dry weight, and in F. achenes at 1.64 ug/g dry weight. High-temperature growing conditions (25 and 30 °C) enhanced total resveratrol content, as did fruit maturation, addition of compost or fertilizer, treatment with methyl jasmonate, and elevated ambient carbon dioxide(1). The commercial tomato varieties MicroTom, UglyRipe, Heirloom /Lycopersicon esculentum/, and PlumTom contained respective resveratrol concentrations of 15.30 ug/g, 0.38 ug/g, 1.75 ug/g, and 0.34 ug/g in the skin. In comparison, a commercial seedless red table grape contained 2680 ug/g resveratrol(2). |
| Plant Concentrations | Phytoalexin found in a variety of plants. It has been isolated from white hellebore /Veratrum album/ and from fescue grass /Festuca sp/(1). Resveratrol is found in grapevines (Vitis vinifera L). It occurs in the wines, roots, seeds and stalks, but its highest concentration is in grape skins(2). Resveratrol is produced by grape vines in response to fungal infection and is known to occur in grapes(3).Fungal infection(1), stress, injury, and ultraviolet irradiation(2) induce resveratrol production in grapevines. Resveratrol was detected in Vitis vinifera and Vitis labrusca grapes, but not in the seeds(3). Resveratrol concentrations of 0.00925 to 4.63 mg/L were detectable in various grape seeds(4). Eurpean grape leaves (Vitis vinifera) were found to contain 90,400 ppm resveratrol(5). Resveratrol has been qualitatively observed in the bark of Yucca schidigera(6), the red dock, Rumex bucephalophorus(7), and Gnetum klossi(8). The root of Mexican Bamboo, a variety of Polygonium cuspidatum, was found to contain 2.96 mg/g dry weight resveratrol(9). |
| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of March 19, 2014: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=501-36-0] |
| Soil Adsorption/Mobility | Using a structure estimation method based on molecular connectivity indices(1), the Koc of resveratrol can be estimated to be 3.5X10+4(SRC). According to a classification scheme(2), this estimated Koc value suggests that resveratrol is expected to be immobile in soil. Resveratrol has estimated pKa values of 8.99, 9.63 and 10.64(3) indicating that this compound will exist primarily in the neutral form in the environment with the anion form partially existing in alkaline soils and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).[(1) US EPAEstimation Program Interface (EPI) Suite. Ver. 4.11. Nov, 2012. Available from, as of Feb 11, 2014: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm (2) Swann RL et alRes Rev 85: 17-28 (1983) (3) Royal Soc ChemChemSpider. 5- |
| Natural Pollution Sources | Resveratrol is a plant-specific enzyme that exists in 72 plant species, such as grapes, peanuts, and pine trees. Grapes are the most abundant source(1). It is produced by grape vines in response to fungal infection(2), stress, injury or ultraviolet irradiation(1). The Chinese medicinal herb Hu Zhang, a variety of Polygonium cuspidatum, contains resveratrol in the root(3). Resveratrol is found in berries of Vaccinum species, including blueberries, bilberries, and cranberries(4).Resveratrol is produced by plants in response to infection by the pathogen Botrytis cinerea ... It is also induced in response to a variety of stress conditions, such as vicissitudes in climate, exposure to ozone, sunlight and heavy metals |
| Human Toxicity Excerpts | /HUMAN EXPOSURE STUDIES/ Voluntary runners are subjected to a massive increase in reactive oxygen/nitrogen species production, which can promote different oxidative stress-related diseases such as premature aging, neurodegenerative disorders, and cancer. The aims of this work were to evaluate the following in peripheral blood cells of voluntary runners: (i) DNA status(ii) susceptibility to the in vitro insult induced by hydrogen peroxide (H(2)O(2)) as a breaking agent(iii) capabilities of 3,5,4'-trihydroxystilbene (RESV) in counteracting DNA damage. Twenty-five male voluntary runners were compared with 20 sedentary men, as age-matched controls, and DNA status was evaluated with different versions of comet assay: alkaline, neutral, and Fpg enzyme-modified version to measure 8-OH-deoxyguanosine (8-oxo-dG) levels. The H(2)O(2) and/or RESV treatments were performed directly on agarose-embedded cells (atypical comet assay). The results evidenced DNA damage and levels of 8-oxo-dG higher in runners than in sedentary control subjects. The runners' DNA was more prone to the in vitro-induced oxidative insult (200 uM H(2)O(2)) than that of the control group. Resveratrol (100 uM), depending on the individual basal DNA status, was able to switch from antioxidant to pro-oxidant. /These/ results, on the one hand, validated the proposed in vitro experimental protocol in order to measure individual DNA status. On the other hand, /the/ data point out the importance of monitoring the athletes' redox status before subjecting them to dietary supplementation treatment./EPIDEMIOLOGY STUDIES/ Chronic obstructive pulmonary disease (COPD) therapy is complicated by corticosteroid resistance of the interleukin 8 (IL-8)-dependent and granulocyte macrophage-colony stimulating factor (GM-CSF)-dependent chronic airway inflammation, for whose establishment human airway smooth muscle cells (HASMCs) might be crucial. It is unclear whether the release of inflammatory mediators from HASMCs is modulated by cigarette smoking and is refractory to corticosteroids in COPD. Resveratrol, an antiaging drug with protective effects against lung cancer, might be an alternative to corticosteroids in COPD therapy. Vascular endothelial growth factor (VEGF) might offer protection from developing emphysema. /The author/ tested the following hypotheses for HASMCs: 1) smoking with or without airway obstruction modulates /Interleukin 8/ (IL-8), GM-CSF, and VEGF releaseand 2) corticosteroids, but not resveratrol, fail to inhibit cytokine release in COPD. Cytokine release from HASMCs exposed to tumor necrosis factor alpha (TNFalpha), dexamethasone, and/or resveratrol was measured via enzyme-linked immunosorbent assay and compared between nonsmokers (NS), smokers without COPD (S), and smokers with COPD (all n = 10). In response to TNFalpha, IL-8 release was increased, but GM-CSF and VEGF release was decreased in S and COPD compared with NS. Dexamethasone and resveratrol inhibited concentration-dependently TNFalpha-induced IL-8, GM-CSF, and VEGF release. For IL-8 and GM-CSF efficiency of dexamethasone was NS > S > COPD. That of resveratrol was NS = S = COPD for IL-8 and NS = S < COPD for GM-CSF. For VEGF the efficiency of dexamethasone was NS = S = COPD, and that of resveratrol was NS = S > COPD. All resveratrol effects were partially based on p38 mitogen-activated protein kinase blockade. In conclusion, smoking modulates cytokine release from HASMCs. Corticosteroid refractoriness of HASMCs in COPD is cytokine-dependent. Resveratrol might be superior to corticosteroids in COPD therapy, because it more efficiently reduces the release of inflammatory mediators and has limited effects on VEGF in COPD./GENOTOXICITY/ Resveratrol ( trans-3,4',5-trihydroxystilbene) is a natural phytoalexin with various biological activities including inhibition of lipid peroxidation and free radical scavenging properties. In addition to its beneficial effects, resveratrol also has significant genotoxicity that leads to a high frequency of chromosome aberration together with micronucleus and sister chromatid exchanges. To enhance the radical scavenging activities and to reduce the genotoxicity of resveratrol, /the authors/ designed 4'-methyl resveratrol analogues where a methyl group was introduced at the ortho position relative to the 4'-hydroxy group, which is responsible for both antioxidative activities and genotoxicity of resveratrol. These synthesized methyl analogues of resveratrol showed increased antioxidative activities against galvinoxyl radical as an oxyl radical species. Furthermore, the methyl analogues also surprisingly showed reduced in vitro genotoxicities, suggesting that methyl substitution may improve resveratrol efficacy./ALTERNATIVE and IN VITRO TESTS/ ... In vitro data generated in human squamous cell carcinoma cells demonstrate that resveratrol induces G1-phase cell cycle arrest, accompanied by p21WAF1/CIP1 induction, and it decreases the cell cycle regulators, cyclins D1/D2/E and Cdks, hyperphosphorylated pRb proteins, MEK1 > ERK1/2, and AP-1 signaling ...For more Human Toxicity Excerpts (Complete) data for RESVERATROL (28 total), please visit the HSDB record page. |
| Artificial Pollution Sources | Resveratrol's production and use as a dietary supplement(1,2) and anti-aging cosmetic ingredient(3) may result in its release to the environment through various waste streams(SRC). |
| Environmental Bioconcentration | An estimated BCF of 50 was calculated in fish for resveratrol(SRC), using a log Kow of 3.10(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). |
| Volatilization from Water/Soil | The Henry's Law constant for resveratrol is estimated as 1.4X10-16 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that resveratrol is expected to be essentially nonvolatile from water surfaces(2). Resveratrol's Henry's Law constant indicates that volatilization from moist soil surfaces is not expected to occur(SRC). Resveratrol is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.2X10-9 mm Hg(SRC), determined from a fragment constant method(1). |
| Water hazard class (WGK) | 3 |
| RTECS number | CZ8987000 |
| Customs code | 29072990 |
| Risk statements (R) | 37/38-41-36/38-36-43-22 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Hazard symbols | Xi |
| Safety statements (S) | 26-39-37/39-36/37/39 |
| Storage class | 11 - Combustible Solids |
| GHS hazard statements | H319 |
| REACH registrations | Inactive |
| Hazard class | Eye Irrit. 2 |
| GHS precautionary statements | P264-P280-P305+P351+P338-P337+P313 |
| Hazardous substances data | 501-36-0(Hazardous Substances Data) |
Applications & Uses
Uses
Resveratrol can prevent the oxidation of low density lipoprotein, and has the potential effect on preventing cardiovascular disease, cancer, antivirus and immune regulation. Its main role is antioxidant properties.Cardiovascular drugs. It can reduce hematic fat and prevent heart disease. It also has the effect on AIDS[4].Antioxidants and the activity in anti-inflammatory, antithrombotic, anti-cancer, anti-cancer, anti hyperlipidemia and antibacterial.Anti-aging, regulating blood lipid, cardiovascular protection, anti-hepatitis.Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.
Uses
Resveratrol is a natural antioxidant. It reduces blood viscosity, inhibits platelet aggregation and vasodilation, keeps blood flowing smoothly, and prevents the occurrence and development of cancer. It has the effect of preventing and treating atherosclerosis, coronary heart disease, ischemic heart disease and hyperlipidemia. It has tumor-inhibiting effects. Resveratrol also has estrogen-like effects and can be used to treat breast cancer and other diseases. It slows down aging and prevents cancer. Red grape skins, red wine and grape juice contain high concentrations of resveratrol. Studies have shown that as humans age, the integrity of chromosomes is disrupted. However, resveratrol activates proteins that can repair chromosomes, thus slowing down aging.Resveratrol is effective in preventing aging, in part due to its antioxidant properties, and is recommended for use in pre- or post-sun products. Resveratrol can cross the stratum corneum and be found in the dermis and epidermis. It has been shown to protect dermal collagen and may be effective in enhancing glycosaminoglycans, thereby improving tissue hydration. It has been shown to stimulate cell renewal in the skin and to help increase skin thickness. It has been shown to inhibit tyrosinase, which suggests it may be used to reduce hyperpigmentation.
Uses
raw material for Tamiflu; Oseltamivir
Uses
Minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.
Description
Resveratrol, a non-flavonoid polyphenolic compound, is widely found in the skin of red grapes, nuts, berries, Polygonum cuspidatum root, etc. It is reportedly known to exhibit pharmacological properties including anti-cancer, anti-inflammatory, antioxidant, neuroprotectant, anti-atherogenic property and reduces the synthesis of pro-atherosclerotic substances.