1-Cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid--hydrogen chloride (1/1)
BAYTRIL · Enorfloxacin HCL · Enrofloxacin hydrochlori · Enrofloxacin Hydrochloide · EenrofloxacinHydrochloride · Enrofloxacin hydrochloride · Enrofloxacin hydrochloride powder · Enrofloxacin hydrochloride USP/EP/BP
Identifiers & Physical Properties
| CAS No. | 112732-17-9 |
|---|---|
| Molecular formula | C19H23ClFN3O3 |
| Average molar mass | 395.9 g/mol |
| Monoisotopic mass | 395.1411975 g/mol |
| SMILES | CCN1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1.Cl |
| InChIKey | PZJWYUDBXNNVLZ-UHFFFAOYSA-N |
| PubChem CID | 45357113 |
| ChEBI | CHEBI:201393 |
| EC No. | 688-293-7 |
| DTXSID | DTXSID20920877 |
Chemical & Physical Properties
| Topological polar surface area | 64.1 |
|---|---|
| Hydrogen bond donors | 2 |
| Hydrogen bond acceptors | 7 |
| Rotatable bonds | 4 |
| Heavy atoms | 27 |
| Formal charge | 0 |
| Complexity | 613 |
| Melting point | >285°C (dec.) |
| Storage conditions | 0-6°C |
| Solubility | Methanol (Slightly, Heated), Water (Slightly) |
| Physical state | Solid |
| Color | White |
| Stability | Hygroscopic |
| InChI | InChI=1S/C19H22FN3O3.ClH/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26) |
| InChIKey | PZJWYUDBXNNVLZ-UHFFFAOYSA-N |
| SMILES | O=C1C(=CN(C2CC2)C2=CC(N3CCN(CC)CC3)=C(F)C=C12)C(=O)O.Cl |
| CAS DataBase Reference | 112732-17-9(CAS DataBase Reference) |
| GHS pictogram | GHS07,GHS08,GHS09 |
| Signal word | Danger |
| GHS hazard statements | H302-H361-H372-H410 |
| GHS precautionary statements | P201-P264-P280-P301+P330+P331-P312 |
| Water hazard class (WGK) | 3 |
| RTECS number | VB1993650 |
Safety & Regulations
| GHS classification | This chemical does not meet GHS hazard criteria for 33.3% (1 of 3) of reports.H411 (66.7%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]P273, P391, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 3 reports by companies from 2 notifications to the ECHA C&L Inventory. |
|---|---|
| Hazard Classes and Categories | Aquatic Chronic 2 (66.7%) |
| Water hazard class (WGK) | 3 |
| RTECS number | VB1993650 |
| Signal word | Danger |
| GHS pictogram | GHS07,GHS08,GHS09 |
| GHS hazard statements | H302-H361-H372-H410 |
| GHS precautionary statements | P201-P264-P280-P301+P330+P331-P312 |
Applications & Uses
Uses
Enrofloxacin Hydrochloride is a fluorinated quinolone antibacterial.
Preparation & Synthesis
Preparation
1. Crude Process: Dissolve enrofloxacin in 1/20 times its volume of water and heat to 90°C. Add hydrochloric acid and act for 30 minutes. Adjust the pH to 3-4 and remove impurities by hot filtration. Adjust the pH to 1 with hydrochloric acid, cool to precipitate crystals, and centrifuge to obtain enrofloxacin hydrochloride. 2. Refined Process: Dissolve crude enrofloxacin hydrochloride in an appropriate amount of distilled water, add 4% activated carbon for decolorization, filter, allow to crystallize naturally, and dry at 80°C for 10 hours to obtain pure enrofloxacin hydrochloride.