Ppads tetrasodium salt

HCID 4881CAS 149017-66-3

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Basic information

Standard SMILES
Cc1nc(N=Nc2ccc(S(=O)(=O)O)cc2S(=O)(=O)O)c(COP(=O)(O)O)c(C=O)c1O
InChIKey
PNFZSRRRZNXSMF-UHFFFAOYSA-N
Molecular formula
C14H14N3O12PS2
Average molar mass
511.38 g/mol

Names & identifiers

Preferred name
Ppads tetrasodium salt
English name
Ppads tetrasodium salt
Molecular formula
C14H14N3O12PS2
Molecular weight
511.38

Names & synonyms

PPADSC13745PPADS tetrasodium saPpads tetrasodium saltPPADS Tetrasodium Salt（149017-66-3）PPADS, P2 purinergic receptor antagonistpyridoxalphosphate-6-azophenyl-2’,4’-disulfonicacid5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acidPYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID 4NAPYRIDOXAL-PHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID TETRASODIUM

Database identifiers

CAS
149017-66-3
PubChem CID
4881
ChEMBL
CHEMBL1437958、CHEMBL3305983、CHEMBL69234
ChEBI
CHEBI:34941
UNII
L6K2LJ9BJK
Nikkaji
J508.318D

Properties

Physicochemical properties

storage temp.
20 °C · −20°C
solubility
2 O: · H2O: >10 mg/mL
form
solid
color
red to orange
FDA UNII
6 K2LJ9BJK · L6K2LJ9BJK
Safety Statements
22 · 22-24/25

Safety & regulation

Safety data

wgk
3
safety_code
22-24/25

Chemistry & industry

Applications · 1 item

UsesPPADS is a P2 receptor antagonist, with IC50s of 68 nM (P2X1) and 214 nM (P2X3). PPADS acts as an ATP (nucleotide) mimetic and competes with ATP for its binding site on P2 receptors. PPADS is also a reversible competitive antagonist of the NAADP receptor. PPADS reverses nociceptive hypersensitivity and reduces the increased NO/NOS system and IL-1β in both peripheral and central steps of nervous system[1][2][3].

Suppliers13 total

上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
Ascent Scientific4401179829988 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
金瓯生物医药（南京）有限公司13000000000 · [email protected]

Additional notes

DefinitionChEBI: An arenesulfonic acid that is pyridoxal 5'-phosphate carrying an additional 2,4-disulfophenylazo substituent at position 6.

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