HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Acetate
NaOAC · Sodium acetate anhydrous · AcONa · Anhydrous sodium acetate · BUFFER SOLUTION · FEMA 3024 · Natriumacetat · sodium ethanoate
Identifiers & Physical Properties
| CAS No. | 127-09-3 |
|---|---|
| Molecular formula | C2H3NaO2 |
| Average molar mass | 82.03 g/mol |
| Monoisotopic mass | 82.00307362 g/mol |
| SMILES | CC(=O)[O-].[Na+] |
| InChIKey | VMHLLURERBWHNL-UHFFFAOYSA-M |
| PubChem CID | 517045 |
| ChEMBL | CHEMBL1354 |
| ChEBI | CHEBI:32954 |
| EC No. | 204-823-8 |
| DTXSID | DTXSID2027044 |
Chemical & Physical Properties
| Topological polar surface area | 40.1 |
|---|---|
| Hydrogen bond donors | 0 |
| Hydrogen bond acceptors | 2 |
| Rotatable bonds | 0 |
| Heavy atoms | 5 |
| Formal charge | 0 |
| Complexity | 34 |
| pH | 8,0-9,5 (1 % aqueous solution)7.87(1 mM solution)8.33(10 mM solution)8.75(100 mM solution)9.04(1000 mM solution) |
| Odor | OdorlessSlight acetic acid |
| Density | 1.528 g/ml1.5 g/cm³1.528 @25 °C1.01 g/mL at 20 °C |
| Color/Form | WHITE GRANULAR POWDER OR MONOCLINIC CRYSTALSColorless |
| Solubility | WATER: 119 G/100 ML @ 0 °C, 170.15 G/100 ML @ 100 °CSLIGHTLY SOL IN ALCOHOLSolubility in water, g/100ml at 20 °C: 46.5H2O: 3 M at 20 °C, clear, colorless500 g/L (20 ºC) |
| Melting point | 324 °C328 °C328.2 °C>300 °C (dec.)(lit.) |
| Vapor pressure | 0.00000071 [mmHg] |
| Refractive index | INDEX OF REFRACTION: 1.4641.4640 |
| Physical Description | Other SolidDry PowderLarge CrystalsLiquidAnhydrous:White, odourless, granular, hygroscopic powderWhite hygroscopic solid[ICSC] Colorless odorless hygroscopic solid[CHEMINFO] White odorless crystalline powder[MSDSonline]WHITE HYGROSCOPIC CRYSTALLINE POWDER. |
| Stability/Shelf Life | SOLUTIONS ARE STABLEEFFLORESCES IN WARM, DRY AIR /SODIUM ACETATE TRIHYDRATE, USP/ |
| Autoignition temperature | 1125 °F /SODIUM ACETATE TRIHYDRATE/607 °C |
| Other Experimental Properties | HYGROSCOPICCOLORLESS, TRANSPARENT CRYSTALS OR GRANULAR, CRYSTALLINE POWDERODORLESS OR HAS FAINT, ACETOUS ODOR. /SODIUM ACETATE TRIHYDRATE, USP/SOL: 76.2 G/100 ML WATER AT 0 °C138.8 G/100 ML WATER @ 50 °C2.1 G/100 ML ALC AT 18 °CSOL IN ETHERINDEX OF REFRACTION: 1.464 (BETA)DENSITY 1.45 G/MLMP 58 °CCOLORLESS MONOCLINIC PRISMS. /SODIUM ACETATE TRIHYDRATE/ |
| FEMA | 3024 | SODIUM ACETATE |
| Flash point | >250 °C |
| Storage conditions | Store at +5°C to +30°C. |
| Physical state | powder |
| pKa (acidity coefficient) | 4.756[at 20 ℃] |
| Specific gravity | 1.45 |
| Color | white |
| PH Range | 8.5 - 9.9 at 246 g/l at 25 °C |
| Odor type | odorless |
| Biological source | synthetic |
| Specific heat capacity | Cp(crystal): 0.97 J/(g·K), at 25℃ |
| Hydrolytic Sensitivity | 0: forms stable aqueous solutions |
| λmax | λ: 260 nm Amax: 0.03λ: 280 nm Amax: 0.02 |
| Sensitivity | Hygroscopic |
| Merck | 14,8571 |
| Boiling point | >400°C(decomposition) |
| BRN | 3595639 |
| Stability | Stable. Incompatible with strong oxidizing agents, halogens. Moisture sensitive. |
| Cosmetics Ingredients Functions | BUFFERINGFRAGRANCE |
| InChI | 1S/C2H4O2.Na/c1-2(3)4/h1H3,(H,3,4)/q+1/p-1 |
| InChIKey | VMHLLURERBWHNL-UHFFFAOYSA-M |
| SMILES | [Na+].CC([O-])=O |
| LogP (partition coefficient) | -3.72 |
| CAS DataBase Reference | 127-09-3(CAS DataBase Reference) |
| FDA 21 CFR | 173.310182.70184.1721582.1721 |
| EWG's Food Scores | 1 |
| FDA UNII | NVG71ZZ7P0 |
| ATC code | B05XA08 |
| NIST Chemistry Reference | Sodium ethanoate(127-09-3) |
| EPA Substance Registry System | Sodium acetate (127-09-3) |
| Absorption | ≤0.01 at 260nm in H2O at 100mM≤0.01 at 280nm in H2O at 100mM |
| UNSPSC Code | 51191566 |
| NACRES | NA.55 |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H320 |
| GHS precautionary statements | P264-P337+P313-P305+P351+P338 |
| Safety statements (S) | 22-24/25 |
| Water hazard class (WGK) | 1 |
| RTECS number | AJ4300010 |
| F | 3 |
| TSCA inventory status | TSCA listed |
| Customs code | 29152200 |
| Storage class | 11 - Combustible Solids |
| Hazardous substances data | 127-09-3(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 3530 mg/kg LD50 dermal Rabbit > 10000 mg/kg |
| REACH registrations | Active |
Safety & Regulations
| GHS classification | This chemical does not meet GHS hazard criteria for 95.4% (1320 of 1383) of all reports.Not ClassifiedReported as not meeting GHS hazard criteria by 1320 of 1383 companies (only 4.6% companies provided GHS information). For more detailed information, please visit ECHA C&L website.Aggregated GHS information provided per 1383 reports by companies from 10 notifications to the ECHA C&L Inventory.Reported as not meeting GHS hazard criteria per 1320 of 1383 reports by companies.There are 7 notifications provided by 63 of 1383 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatory information | Chemical: Acetic acid, sodium saltAcetic acid, sodium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, sodium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 27-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15311Sodium acetate: Does not have an individual approval but may be used under an appropriate group standard |
| Other safety information | IMAP assessments - Acetic acid, sodium salt: Human health tier I assessmentIMAP assessments - Acetic acid, sodium salt: Environment tier I assessment |
| Fire hazards | Combustible. |
| Hazards summary | Emergency treatment: Irritants[HSDB] A mild skin and eye irritant[ICSC] May cause mild skin and eye irritation, based on animal studies[CHEMINFO] Causes toxic psychosis in rabbits after intravenous dose >1300 mg/kg[RTECS] |
| FDA requirements | Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended21 U.S.C. 321-392).The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl sodium acetate, approved on the basis of safety and effectiveness by FDA under sections 505 and 507 of the Federal Food, Drug, and Cosmetic Act.Substances migrating to food from cotton and cotton fabrics used in dry food packaging that are generally recognised as safe for their intended use include sodium acetate.Substance added directly to human food affirmed as generally recognized as safe (GRAS) when in compliance with specified requirements.Sodium acetate used as a general purpose food additivin animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice. |
| TSCA requirements | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Sodium acetate is produced, as an intermediate or a final product, by process units covered under this subpart. |
| EPA Safer Chemical | Chemical: Sodium acetateGreen circle - The chemical has been verified to be of low concern based on experimental and modeled data.Chemical: Sodium acetate hydrate |
| FIFRA requirements | Residues of sodium acetate are exempted from the requirement of a tolerance when used as a buffer in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. |
| Chemical Dangers | Decomposes on heating and on contact with strong acids. This produces acetic acid fumes. Reacts violently with strong oxidants. The solution in water is a weak base. |
| Hazard Classes and Categories | Not Classified |
| Explosive Limits and Potential | Combustible |
| Hazardous Reactivities and Incompatibilities | Violent reaction with flourine and potassium nitrate, diketene. |
| Fire fighting | Use water spray, foam, powder, carbon dioxide. |
| First aid measures | Fresh air, rest.Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. |
| Safe storage | Dry. Separated from strong acids and strong oxidants. |
| Spillage disposal | Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. |
| Eye Prevention | Wear safety goggles. |
| Fire Prevention | NO open flames. |
| Inhalation Risk | No indication can be given about the rate at which a harmful concentration of this substance in the air is reached. |
| Skin Prevention | Protective gloves. |
| Allowable Tolerances | Residues of sodium acetate are exempted from the requirement of a tolerance when used as a buffer in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. |
| Ingestion Prevention | Do not eat, drink, or smoke during work. |
| Inhalation Prevention | Use local exhaust. |
| Effects of Short Term Exposure | The substance is mildly irritating to the eyes and skin. |
| Interactions | ITS ORAL USE SPEEDS METABOLISM OF & LOWERS ETHYL ALCOHOL LEVEL IN RATS' BLOOD.IV SODIUM ACETATE DID NOT REVERSE MYOCARDIAL DEPRESSION INDUCED BY HALOTHANE WHEN ADMIN TO DOGS. ACETATE, A WELL-ESTABLISHED PERIPHERAL VASCULAR VASODILATOR, DID DECR LEFT VENTRICULAR & AORTIC PRESSURES. |
| Health effects | Silver itself is not toxic to humans, but most silver salts are. In large doses, silver and compounds containing it can be absorbed into the circulatory system and become deposited in various body tissues, leading to argyria, which results in a blue-grayish pigmentation of the skin, eyes, and mucous membranes. Argyria is rare, and although, so far as known, this condition does not otherwise harm a person's health, it is disfiguring and usually permanent. Mild forms of argyria are sometimes mistaken for cyanosis. (L809) |
| Exposure routes | The substance can be absorbed into the body by ingestion.Oral (L808)inhalation (L808)dermal (L808) |
| Toxicity summary | Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.orgMetallic silver is oxidized and may deposit in the tissues, causing arygria. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions and intracellular ion concentrations, respectively. Silver nanoparticles are believed to disrupt the mitochondrial respiratory chain, causing oxidative stress, reduced ATP synthesis, and DNA damage. (L808, A243, A244, A245, A246) |
| Signs and Symptoms | Redness.Exposure to high levels of silver for a long period of time may result in a condition called arygria, a blue-gray discoloration of the skin and other body tissues. Argyria is a permanent effect but does not appear to be harmful to health. Exposure to high levels of silver in the air has resulted in breathing problems, lung and throat irritation, and stomach pains. Skin contact with silver can cause mild allergic reactions such as rash, swelling, and inflammation in some people. (L808) |
| Human Toxicity Excerpts | SISTER CHROMATID EXCHANGE - IN VITRO CHROMOSOMAL EFFECT STUDIES, HUMAN: NEGATIVE.Acetate is the primary breakdown product of ethanol metabolism in the liver. ... Systemically administered acetate has been shown to cause motor impairment, an effect which is blocked by the adenosine receptor blocker, 8-phenyltheophylline. The effects of sodium acetate were investigated using intracellualr recording techniques in rat hippocampal dentate granule cells, and were compared to the actions of ethanol and adenosine individually and in conjunction with 8-phenyltheophylline. Acetate hyperpolarized the membrane of 0.4-0.8 mM. The amplitude and duration of the postspike train after hyperpolarization were increased by acetate when the cell was repolarized to the control resting membrane potential. Comparable results were seen in voltage clamp. Acetate also decreased spike frequency adaptation. The effects of acetate were mimicked by adenosine (50 uM) and ethanol (20 mM). The ethanol effects occluded those produced by acetate. All of the effects of acetate, adenosine and ethanol could be inhibited with prior perfusion of 8-phenyltheophylline (1-10 uM). These data suggest that the actions of the major metabolite of ethanol, acetate, and adenosine may be mediated by adenosine receptor activation. |
| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
| Non-Human Toxicity Excerpts | TEST CONDITIONS WERE: INJECTION VIA AIR CELL & VIA YOLK& AT 2 TIMES, PREINCUBATION (0 HR) & 96 HR. AT LEAST 100 EMBRYOS/DOSE LEVEL WERE TREATED. SODIUM ACETATE WAS NONTERATOGENIC.Sodium acetate was evaluated using the Chernoff/Kavlock in vivo teratology screen procedure. End points analyzed as part of this assay were maternal toxicity and early postnatal growth/viability of offspring. Thirty pregnant CD 1 mice were given 1000 mg/kg/day of sodium acetate by gavage on days 8-12 of gestation and allowed to deliver. Forty vehicle-treated animals were used as controls. Sodium acetate induced no observable adverse effects in the dams or their offspring when compared with controls.Sodium acetate, tested on rabbit eyes as 0.1 M solution adjusted to pH 7.0 to 7.5 and made 0.46 osmolar with sodium chloride or sucrose, caused no disturbance of the cornea, though applied continuously for 3 hr.IP ADMIN TO SWISS WEBSTER MICE DELAYED & REDUCED INCIDENCE OF HYPOGLYCEMIC REACTIONS. THE ACETATE DIRECTLY ACTED TO PREVENT SIGNS OF HYPOGLYCEMIA FROM OCCURRING & REVERSED ITS MAINFESTATIONS WHEN PRESENT. |
| Toxicity Data | LC50 (rat) > 30,000 mg/m3/1h |
| Non-Human Toxicity Values | LD50 Rat oral 3500 mg/kgLD50 Mouse oral 4960 mg/kg |
| F | 3 |
| Water hazard class (WGK) | 1 |
| TSCA inventory status | TSCA listed |
| RTECS number | AJ4300010 |
| Customs code | 29152200 |
| Toxicity | LD50 orally in Rabbit: 3530 mg/kg LD50 dermal Rabbit > 10000 mg/kg |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Safety statements (S) | 22-24/25 |
| Storage class | 11 - Combustible Solids |
| GHS hazard statements | H320 |
| REACH registrations | Active |
| Autoignition temperature | 607 °C |
| GHS precautionary statements | P264-P337+P313-P305+P351+P338 |
| Hazardous substances data | 127-09-3(Hazardous Substances Data) |
Applications & Uses
Description
Sodium acetate (CH3COONa) is the sodium salt of acetic acid. It appears as a colorless deliquescent salt with a wide range of applications. In industry, it can be used in textile industry to neutralize sulfuric acid waste streams and as a photoresist upon using aniline dyes. In concrete industry, it can be used as a concrete sealant to mitigate the water damage. In food, it can be used as a seasoning. It can also be used as a buffer solution in lab. In addition, it is also used in heating pads, hand warmers and hot ice. For laboratory use, it can be produced by the reaction between acetate with the sodium carbonate, sodium bicarbonate and sodium hydroxide. In industry, it is prepared from the glacial acetic acid and sodium hydroxide.
Occurrence
Acetic acid or acetates are present in most plant and animal tissues in small, but detectable amounts
Uses
Used as buffers. Acidity regulation (buffering) Sodium acetate mixed with acetic acid forms a pH buffer, which can be used to stabilise the pH of foods in the pH-range from 3 to 6. The table below gives indicative values of the composition needed to give a certain pH. The mixtures below can be diluted at least 10 times with minimum effect on pH, however, the stability decreases.
Uses
Sodium acetate is a mordant in dyeing. Other applications are in photography, as an additive to food, in purification of glucose, in preservation of meat, in tanning, and as a dehydrating agent. In analytical chemistry it is used to prepare buffer solution. Sodium acetate can be used to preserve processed meats and it is often used in combination with other acid based preservatives like lactates and propionates. The typical inclusion level is 0.2 to 0.5%. Sodium acetate is also used in salad dressings and ready-to-eat meals.
Uses
Sodium Acetate, Anhydrous is a source of acetic acid obtained as a granular powder. it has a solubility of 1 g in 2 ml of water.
General Description
Sodium Acetate is reported to inhibit the growth of Listeria monocytogenes.
Preparation & Synthesis
Preparation
Sodium acetate is prepared by reacting sodium hydroxide or sodium carbonate with acetic acid in aqueous solution. The solution is evaporated to obtain hydrated crystals of sodium acetate. NaOH + CH3COOH → CH3COONa + H2O Na2CO3 + CH3COOH → 2CH3COONa + CO2 + H2O