Talnetant (HCID 5311424)

Overview

Talnetant (SB-223,412) is a neurokinin 3 receptor antagonist developed by GlaxoSmithKline, which is being researched for several different functions, primarily for irritable bowel syndrome and as a potential antipsychotic drug for the treatment of schizophrenia.

Names & identifiers

Preferred name: Talnetant
IUPAC: 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
English name: SB 223412
Molecular formula: C25H22N2O2
Molecular weight: 382.45

Names & synonyms

Talnetant174636-32-9SB 223412SB-2234123-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamideCZ3T9T146KDTXSID00870124talnetantum3-hydroxy-2-phenyl-N-((1S)-1-phenylpropyl)quinoline-4-carboxamideRefChem:187318DTXCID701509648Talnetant [INN]

Show more names

CS-1123Talnetant (SB 223412)Talnetant, 10 mM in DMSO3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide(S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide(S)-3-Hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide

4-Quinolinecarboxamide, 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-3-hydroxy-2-phenyl-n-[(1S)-1-phenylpropyl]-4-quinolinecarboxamideUNII-CZ3T9T146KMFCD00944075CHEMBL10188GTPL2132CS-1638SB223412

Database identifiers

CAS: 174636-32-9
PubChem CID: 5311424
DTXSID: DTXSID00870124
ChEMBL: CHEMBL10188
UNII: CZ3T9T146K
EC Number: 808-582-5
Nikkaji: J750.057B

Properties

Computed structural properties

XLogP: 5.7
Topological polar surface area: 62.2 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 3
Rotatable bonds: 5
Heavy atoms: 29
Formal charge: 0
Complexity: 527

Experimental & physicochemical properties

DrugsPharmaceuticals -> Listed in ZINC15

LogP3.91

Physicochemical properties

Melting point: 125.1 · 125.1-126.2℃
Boiling point: 580.4 · 580.4±50.0 °C(Predicted)
Density: 1.212 · 1.212±0.06 g/cm3(Predicted)
storage temp.: 2 · Sealed in dry,2-8°C
solubility: 25 mg/mL, · DMSO: soluble25mg/mL, clear
pka: 6.7 · 6.70±0.50(Predicted)
form: powder
color: white to beige
optical activity: -25 to · [α]/D -25 to -31°, c = 0.5 in methanol
InChI: 1S/C25H22N2O2/c1-2-20(17-11-5-3-6-12-17)27-25(29)22-19-15-9-10-16-21(19)26-23(24(22)28)18-13-7-4-8-14-18/h3-16,20,28H,2H2,1H3,(H,27,29)/t20-/m0/s1
InChIKey: BIAVGWDGIJKWRM-FQEVSTJZSA-N
SMILES: OC(C(C(N[C@H](C1=CC=CC=C1)CC)=O)=C(C=CC=C2)C2=N3)=C3C4=CC=CC=C4
FDA UNII: 3 T9T146K · CZ3T9T146K
UNSPSC Code: 12352200 · 12352200
NACRES: 77 · NA.77
Symbol(GHS): 6 · GHS06
Signal word: Danger
Hazard statements: 301 · H301
Precautionary statements: 301 · P301+P310
Hazard Codes: T
Risk Statements: 25 · 25
Safety Statements: 45 · 45
RIDADR: 2811 · UN 2811 6.1 / PGIII
WGK Germany: 3 · WGK 3
Storage Class: 6.1 C · 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
Hazard Classifications: 3 Oral · Acute Tox. 3 Oral

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory.

Hazard information

Hazard Classes and CategoriesAcute Tox. 3 (100%)

Safety data

wgk: WGK 3
ridadr: UN 2811 6.1 / PGIII
risk_code: 25
Signal word: Danger
Symbol(GHS): GHS06
hazard_code: T
safety_code: 45
Storage Class: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
Hazard statements: H301
Hazard Classifications: Acute Tox. 3 Oral
Precautionary statements: P301+P310

Chemistry & industry

Applications · 2 items

DescriptionTalnetant is an antagonist of the neurokinin-3 (NK3) receptor (Ki = 1 nM). It is selective for NK3 over NK1 and NK2 receptors (Kis = 144 and >100,000 nM, respectively, in CHO cells expressing recombinant human receptors). Talnetant inhibits calcium mobilization induced by neurokinin B in HEK293 cells expressing human NK3 receptors (IC50 = 16.6 nM). It inhibits contractions induced by the NK3 receptor agonist senktide in isolated rabbit iris sphincter muscle (pD2 = 9.1). Talnetant (5-20 mg/kg) reduces senktide-induced head shakes and tail whips in mice. It also inhibits senktide-induced wet-dog shakes, increases extracellular dopamine and norepinephrine in the medial prefrontal cortex, and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs.

UsesTalnetant acts as a neurokinin 3 (NK3) receptor antagonist used as an antispychotic.