HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiram
TMTD · THIRAM · 1,1’-dithiobis(n,n-dimethylthio-formamid · THIURAM · TETRAMETHYLTHIURAM DISULPHIDE · Tetramethylthiuram · TNTD · tmtc
Identifiers & Physical Properties
| CAS No. | 137-26-8 |
|---|---|
| Molecular formula | C6H12N2S4 |
| Average molar mass | 240.4 g/mol |
| Monoisotopic mass | 239.98833309 g/mol |
| SMILES | CN(C)C(=S)SSC(=S)N(C)C |
| InChIKey | KUAZQDVKQLNFPE-UHFFFAOYSA-N |
| PubChem CID | 5455 |
| ChEMBL | CHEMBL120563 |
| ChEBI | CHEBI:9495 |
| EC No. | 205-286-2 |
| DTXSID | DTXSID5021332 |
Chemical & Physical Properties
| XLogP | 1.7 |
|---|---|
| Topological polar surface area | 121 |
| Hydrogen bond donors | 0 |
| Hydrogen bond acceptors | 4 |
| Rotatable bonds | 3 |
| Heavy atoms | 12 |
| Formal charge | 0 |
| Complexity | 158 |
| LogP (partition coefficient) | log Kow = 1.731.82 |
| Odor | Characteristic odor |
| Density | 1.43 at 68 °F (USCG, 1999) - Denser than waterwill sink1.3 g/cu cm1.3 g/cm³1.3 @25 °C1.29 |
| Color/Form | White crystalline powderColorless to yellow, crystalline solid. (Note: commercial pesticide product may be dyed blue.) |
| Solubility | less than 1 mg/mL at 72 °F (NTP, 1992)Solubility in alcohol and in ether less than 0.2%solubility in acetone 1.2%in benzene 2.5%.Sol in carbon disulfideSolubility in ethanol <10 g/L at 25 °C, acetone 80 g/L at 25 °C, chloroform 230 g/L at 25 °C, hexane 0.04 g/L at 20 °Cdichloromethane 170 g/L at 20 °C, toluene 18 g/L at 20 °C, isopropanol 0.7 g/L at 20 °C.In water, 30 mg/L at 25 °CSolubility in water: none0.0184g/l16.5 mg/L (20 ºC) |
| Corrosivity | Non-corrosive in the dry state. |
| Flash point | 280 °F (NTP, 1992)89 °C (192 °F) (closed cup)89 °C c.c.89°C |
| Boiling point | 264 °F at 20 mmHg (NTP, 1992)129 °C at 20 mm Hgat 2.6kPa: 129 °C264 °F at 20 mmHgDecomposes129 °C (20 mmHg) |
| Melting point | 311 to 313 °F (NTP, 1992)155-156 °CMP: 146 °C /Commercial grade/312 °F156-158 °C(lit.) |
| Odor threshold | 5 mg/cu m |
| Vapor pressure | 0 mmHg at 68 °F approximately (NTP, 1992)0.0000172 [mmHg]1.72X10-5 mm Hg at 25 °CVapor pressure at 20 °C: negligible0.000008 mmHg0.000017 [mm Hg] @25 °C8 x 10-6 mmHg at 20 °C (NIOSH, 1997) |
| Henry's law constant | Henry's Law constant = 3.26X10-7 atm-cu m/mol at 25 °C9.3×101 mol/(m3Pa) at 25℃, Mackay et al. (2006) |
| Refractive index | 1.5500 (estimate) |
| Storage conditions | under inert gas (argon) |
| Physical state | solid |
| pKa (acidity coefficient) | 0.87±0.50(Predicted) |
| Specific heat capacity | Cp(crystal): 1.25 J/(g·K), at 25℃ |
| Merck | 14,9371 |
| BRN | 1725821 |
| Exposure limits | ACGIH:TLV-TWA 0.05 mg/m3 (0.005 ppm),Inhalable fraction and vaporOSHA:PEL-TWA 5 mg/m3NIOSH:REL-TWA 5 mg/m3 |
| Cosmetics Ingredients Functions | ANTIMICROBIAL |
| InChI | 1S/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3 |
| InChIKey | KUAZQDVKQLNFPE-UHFFFAOYSA-N |
| SMILES | CN(C)C(=S)SSC(=S)N(C)C |
| LogP (partition coefficient) | 1.730 |
| Indirect Additives used in Food Contact Substances | THIRAM |
| FDA 21 CFR | 175.105177.2600 |
| CAS DataBase Reference | 137-26-8(CAS DataBase Reference) |
| EWG's Food Scores | 5-8 |
| FDA UNII | 0D771IS0FH |
| ATC code | P03AA05 |
| NIST Chemistry Reference | Thiram(137-26-8) |
| IARC | 3 (Vol. Sup 7, 53) 1991 |
| EPA Substance Registry System | Thiram (137-26-8) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
| GHS pictogram | GHS07,GHS08,GHS09 |
| Signal word | Danger |
| GHS hazard statements | H302+H332-H315-H319-H361-H372-H370-H317-H340-H410 |
| GHS precautionary statements | P501-P273-P272-P260-P270-P202-P201-P271-P264-P280-P302+P352-P391-P337+P313-P305+P351+P338-P308+P311-P362+P364-P333+P313-P301+P312+P330-P304+P340+P312-P405 |
| Target organs | Liver |
| Personal protective equipment (PPE) | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard symbols | Xn,N |
| Risk statements (R) | 20/22-36/38-43-48/22-50/53 |
| Safety statements (S) | 26-36/37-60-61 |
| Occupational exposure band (OEB) | B |
| Occupational exposure limit (OEL) | TWA: 5 mg/m3 |
| UN transport number | UN 2771/2811 |
| Water hazard class (WGK) | 3 |
| RTECS number | JO1400000 |
| Autoignition temperature | 316 °F |
| TSCA inventory status | TSCA listed |
| Hazard class | 9Acute Tox. 4 InhalationAcute Tox. 4 OralAquatic Acute 1Aquatic Chronic 1Eye Irrit. 2Skin Irrit. 2Skin Sens. 1STOT RE 2 Oral |
| Packing group | III |
| Customs code | 29303000 |
| Storage class | 13 - Non Combustible Solids |
| Hazardous substances data | 137-26-8(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 640 mg/kg (Gaines) |
| Immediately dangerous to life or health concentration | 100 mg/m3 |
| REACH registrations | Active |
| Limited quantities | 5.0 kg (11 lbs) (solid) |
| Excepted quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
Safety & Regulations
| GHS classification | WarningH302: Harmful if swallowed [Warning Acute toxicity, oral]H315: Causes skin irritation [Warning Skin corrosion/irritation]H317: May cause an allergic skin reaction [Warning Sensitization, Skin]H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]H332: Harmful if inhaled [Warning Acute toxicity, inhalation]H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement) |
|---|---|
| Regulatory information | Chemical: Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,Nâ²,Nâ²-tetramethyl-Hazard Traits - NeurotoxicityAuthoritative List - IRIS NeurotoxicantsReport - if used as a fragrance or flavor ingredientRegulation (EC) No 396/2005 (amended)Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N',N'-tetramethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N',N'-tetramethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Thiram is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)03/81/EC, Reg. (EU) 2016/2016, Reg. (EU) No 540/2011, Reg. (Eu) 2018/1500, Reg.(EU)2018/524 |
| Other safety information | IMAP assessments - Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetramethyl-: Human health tier II assessment |
| DOT label | Poison |
| Fire hazards | Special Hazards of Combustion Products: Toxic and irritating oxides of sulfur are formed. Carbon disulfide may be formed from unburned material. (USCG, 1999)Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air. |
| Health hazards | Inhalation of dust may cause respiratory irritation. Liquid irritates eyes and skin and may cause allergic eczema in sensitive individuals. Ingestion causes nausea, vomiting, and diarrhea, all of which may be persistentparalysis may develop. (USCG, 1999) |
| Hazards summary | An irritant and a skin sensitizer, thiram is classified as slightly toxic. [EXTOXNET] No increased tumors in chronic studies of rodentsReproductive endpoints are not generally altered and the fetal animal does not appear to be more sensitive. [ACGIH] The EBCDCs (ethylenebisdithiocarbamates) can cause irritant and allergic contact dermatitis. EBDCs include ferbam, vapam, maneb, mancozeb, zineb, thiram, and ziram. They are also used as rubber accelerators. Ethylene thiourea (ETU), which may contaminate EBCDCs, is carcinogenic and teratogenic in animal experiments. [LaDou, p. 610] ETU is the major metabolite of EBDCs. [Krieger, p. 1690] See the agent, Ethylene thiourea. |
| DOT ID and guide | 2771 151 |
| FDA requirements | Thiram is an indirect food additive for use only as a component of adhesives. |
| Reactive group | Thiocarbamate Esters and Salts/Dithiocarbamate Esters and Salts |
| EC classification | Symbol: Xn, NR: 20/22-36/38-43-48/22-50/53S: (2)-26-36/37-60-61 |
| UN classification | UN Hazard Class: 9UN Pack Group: III |
| Special Reports | California Environmental Protection Agency/Department of Pesticide RegulationToxicology Data Review Summaries. Available from: http://www.cdpr.ca.gov/docs/toxsums/toxsumlist.htm on Thiram (137-26-8) as of April 20, 2005.USEPA/Office of Pesticide ProgramsReregistration Eligibility Decision Document - Thiram. September 2004. The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of June 1, 2005: http://www.epa.gov/pesticides/reregistration/status.htm] |
| Fire fighting | Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:SMALL FIRE: Dry chemical, CO2 or water spray.LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Avoid aiming straight or solid streams directly onto the product.FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzlesif this is impossible, withdraw from area and let fire burn. (ERG, 2024)Use water spray, powder, foam, carbon dioxide. |
| First aid measures | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Refer for medical attention . |
| First aid | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.INHALATION: IMMEDIATELY leave the contaminated areatake deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be usedif not available, use a level of protection greater than or equal to that advised under Protective Clothing.INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)(General first aid procedures)Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.Breathing: Respiratory supportSwallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. |
| Safe storage | Separated from acids, strong oxidants and food and feedstuffs. Dry. Keep in a well-ventilated room. |
| Exposure control and personal protection | 1.0 [mg/m3], inhalable fraction[German Research Foundation (DFG)] |
| Fire fighting procedures | Fire Fighting: Self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode.If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use foam, dry chemical, or carbon dioxide. Use water in flooding quantities as fog. Apply water from as far a distance as possible. Keep run-off water out of sewers and water sources. |
| Storage conditions | Keep out of reach of children. Keep away from food, drink and animal feeding stuffs. |
| Cleanup methods | If thiram is spilled, the following steps should be taken: 1. Ventilate area of spill. 2. For small quantities, sweep onto paper or other suitable material, place in an appropriate container. Quantities may be reclaimed.Environmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.Environmental considerations: Water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses. Land spill: dig a pit, pond, lagoon, holding area to contain liquid or solid material. Dike surface flow using soil, sand bags, foamed polyurethane,or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. Apply "universal" gelling agent to immobilize spill. Apply appropriate foam to diminish vapor and fire hazard.Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. |
| Nonfire spill response | Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. For solids, prevent dust cloud and avoid inhalation of dust. (ERG, 2024) |
| Disposal methods | Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U244, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.Thiram may be disposed of: 1. By making packages of thiram in paper or other flammable material and burning in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. 2. By dissolving thiram in a flammable solvent (such as alcohol) and atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.Thiram can be dissolved in alcohol or other flammable solvents and burned in an incinerator with an afterburner and scrubber. Recommendable method: Incineration.Incineration: Waste thiram should be disposed of by incineration. Bags should be thoroughly emptied before disposal. Empty bottles and drums should be thoroughly drained and triple rinsed. "Triple rinse" means the flushing of containers three times, each time using a volume of the normal diluent equal to approx ten percent of the container's capacity, and adding the rinse liquid to the spray mixture or disposing of it by a method prescribed for disposing of the pesticide. |
| Spillage disposal | Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations. |
| Preventive Measures | Avoid long-term exposure, even to small quantities ... . Do not consume alcohol on a day when thiram is used.Eating and smoking should not be permitted in areas where thiram is handled, processed or stored.Persons not wearing protective equipment and clothing should be restricted from areas of spills until cleanup has been completed.Clothing contaminated with thiram should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of thiram from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the thiram, the person performing the operation should be informed of thiram's hazardous properties.For more Preventive Measures (Complete) data for THIRAM (16 total), please visit the HSDB record page. |
| Interactions | Like most dithiocarbamates, thiram induces accumulation of acetaldehyde in blood of rats receiving ethanol at same time. Its reaction with nitrite at acid pH in stomachs of guinea pigs in vivo gives rise to n-nitrosodimethylamine.Simultaneous admin of thiram and 10 mg/animal L-cysteine ip from day 5-15 of pregnancy resulted in significant decrease both in severity and in number of embryopathies.Possible interactions between thiram and some drugs, ie, promethazine, meprobamate, and trihexyphenidyl, acting on the central nervous system were studied in rats by behavioral methods. Promethazine also inhibited orientation hypermotility, open-field behavior, and learning ability of rats only in high doses. A 10 mg/kg dose of thiram induced only a moderate decrease in the behavioral activity. In combination the inhibitory effect significantly increased. Thus, there was a definite synergism between the two. The dose-dependent decrease in the behavioral parameters from meprobamate was enhanced to a great extent by combination with thiram. The rate of interaction (synergism) was less than that seen for promethazine. Pretreatment with thiram before trihexylphenidyl (stimulation at < 40 mg/kg and inhibition at higher dose) resulted in the suspension of psychostimulant-like effect of the drug and enhancement of the inhibition. The pesticide-drug interaction was in all cases dose dependent.Lead concentrations in blood and brain were measured in rats exposed to lead via drinking water, 0.25% lead (12 mM), and dithiocarbamate/thiram derivatives administered by gavage singly or in combination for 6 weeks. Diethyldithiocarbamate and dimethyldithiocarbamate were given in doses of 0.2 mmol/kg and thiram and disulfiram in doses of 0.1 mmol/kg twice a week. In rats that received lead + dithiocarbamate/thiram derivatives lead concentrations in blood and brain were significantly increaseddisulfiram being most effective in increasing lead levels, followed by thiram, dimethyldithiocarbamate and diethyldithiocarbamate. In blood, lead levels were increased 3-fold and in brain almost 4-fold after treatment with lead + disulfiram compared to treatment with lead alone. When rats were given diethyldithiocarbamate or thiram by gavage (0.1 mmol/kg/day 5 days a week for 2 weeks) after cessation of the lead treatment, there was no increase in blood lead levels but in thiram-treated rats brain lead concentration was increased 2.7-fold. In rats treated with diethyldithiocarbamate ip after cessation of lead treatment, both blood and brain concentration of lead were increased. Apparently, combined exposure of lead and dithiocarbamate/thiram derivative causes a substantial increase in brain levels of lead which are not always reflected in increases of blood lead levels. This interaction effect ought to be taken into consideration when evaluating the health effects of environmental and occupational lead exposure.For more Interactions (Complete) data for THIRAM (10 total), please visit the HSDB record page. |
| Target organs | NervousEyes, skin, respiratory system, central nervous systemLiver |
| Ecotoxicity values | LD50 Anas Platyrhynchos (Mallard duck, female 3 month old) oral >2800 mg/kg /sample purity >/=99%/LD50 Phasianus colchicus (Ring-necked pheasant, male 3-4 months old) oral 673 mg/kg (95% confidence limit: 485-932 mg/kg) /sample purity >/= 99%/LD50 /Agelaius phoeniceus/ (Redwing blackbird) oral >100 mg/kgLC50 Cyprinus carpio (carp) 4 mg/l. /Conditions of bioassay not specified/For more Ecotoxicity Values (Complete) data for THIRAM (32 total), please visit the HSDB record page. |
| Environmental fate | TERRESTRIAL FATE: Based on a classification scheme(1), a measured Koc value of 676(2) indicates that thiram is expected to have low mobility in soil(SRC). Volatilization of thiram from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 3.26X10-7 atm-cu m/mole(3). Thiram is not expected to volatilize from dry soil surfaces(SRC) based upon an a vapor pressure of 1.72X10-5 mm Hg(2). The rate constant for the photolysis of thiram in soil has been reported to be 0.0346 per day(7). This rate constant corresponds to a half-life of 20 days(SRC). Microbial degradation in soil is expected since thiram has been reported to degrade faster in unsterilized soil than in sterilized soilhowever, degradation rates were not specified(4). Half-lives for thiram measured during soil field studies range from 1 day to 15 weeks(5,6).TERRESTRIAL FATE: Thiram, at a concentration of 180 ppm thoroughly distributed in soil, had a half-life of 1-2 days(1). However, when it was added as a dressing on 0.7 mm glass beads, approximately 10% degradation was observed after 21 days(1). Thiram applied to soil at 100 and 1000 ppm persisted for 4 and >32 weeks, respectively(2). In soil with humus content less than or equal to 1.2%, an initial lag in the decomposition of thiram has been observed(3). Thiram persisted over two months in sandy soil, but disappeared within one week in a compost soil(2). In addition, thiram has been more persistent in sandy soil than laterite and alluvial soils(2). The half-life of thiram applied to bareground and turf plots of sandy loam soil (pH 8.2-9.6) were 27.4 days and 14.4 days, respectively, during terrestrial field studies in California(4). Degradation was biphasic, with rapid initial degradation during the first week followed by much slower degradation(4). Half-lives of thiram applied to bareground (pH 4.1-4.7) and turf plots (pH 4.4-4.5) of sandy loam soil were 36 days and 62.5 days, respectively, during terrestrial field studies in North Carolina(4). In sandy soil humus at pH 3.5, thiram was largely decomposed after 4-5 weeks(5). Thiram decomposed after 14-15 weeks in soil at pH 7.0(5). Persistence of thiram in soil was much greater at 1000 ppm than at 100 ppm in soil(6). However, many of the soil microflora were killed at these concentrations(6).AQUATIC FATE: Based on a classification scheme(1), a Koc value of 676(2), indicates that thiram is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 3.26X10-7 atm-cu m/mole(4). According to a classification scheme(5), BCF values of 1.1-4.4(6) suggest bioconcentration in aquatic organisms is low(SRC). The hydrolysis half-lives measured for thiram at pH 5, pH 7 and pH 9 were 68.5 days, 3.5 days, and 6.9 hours, respectively(7). The rate constant for the photolysis of thiram in water has been reported to be 3.8 per day, which corresponds to a half-life of 4.3 hours(8). Biodegradation is not expected to be an important fate process in water(SRC) based on 2.8% to 30% degradation after 20 days in screening tests using sewage sludge innocula(6,9,10). The half-life of thiram measured during a monitoring study conducted on the Po River in Italy was 15 days(11).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), thiram, which has a vapor pressure of 1.72X10-5 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase thiram is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 1 hour(SRC), calculated from its rate constant of 3.62X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase thiram may be removed from the air by wet and dry deposition(SRC). |
| Adverse effects | Skin Sensitizer - An agent that can induce an allergic reaction in the skin.ACGIH Carcinogen - Not Classifiable. |
| Exposure routes | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.inhalation, ingestion, skin and/or eye contact |
| Average Daily Intake | The acute dietary exposure for the general U.S. population has been estimated to be 0.019022 mg/kg/day(1). The chronic dietary exposure for the general U.S. population has been estimated to be 0.000121 mg/kg/day(1).The estimated daily intakes of dithiocarbamates (including thiram) for Danish farmers with low (166 farmers), medium (39 farmers), and high (46 farmers) consumption of organically grown foods were 12.747, 12.995, and 4.432 ug/person-day, respectively(1). |
| Ecotoxicity excerpts | /BIRDS and MAMMALS/ Mallards showed transient ataxia only. Pheasants showed tachypnea, wing drop, reluctance to move, fluffed feathers, ptosis, diarrhea, tremors like those produced by chlorinated organic compounds, immobility. /sample purity > or = 99%//AQUATIC SPECIES/ Acute toxicity experiments (24, 48, 72, and 96 hours) were carried out with an aqueous suspension of thiram. Animal sensitivity was variable. The six species can be classified according to increasing sensitivity as follows: Asellus, Lymnaea, Gammarus and Cloeon larvae at one level, Dugesia and Xenopus larvae. The spectrum of thiram activity is in the range of 10 ppb to 5000-6000 ppm. Thus, thiram presents a real threat to freshwater fauna./AQUATIC SPECIES/ Thiram, a dithiocarbamate fungicide, evolved to dimethylnitrosamine when associated with nitrites. Conditions of appearance of the carcinogenic compound were studied in short-term experiments by association of the fungicide, nitrates or nitrites, and species representative of freshwater biota. Dimethylnitrosamine was estimated by GLC equipped with a specific detector. Chlorella vulgaris can rapidly produce nitrites from nitrates and dimethylnitrosamine is obtained in presence of thiram. Daphnia magna can also synthesize dimethylnitrosamine but nitrites have to be added to the medium. Increased toxicity of thiram is observed. The same results are obtained on Cyprinus carpio and for a part on Brachydanio rerio. When the species are associated in a 15-day experimental food chain, and intoxicated algae feed the 2 other levels, no significant transfer is observed. Some dimethylnitrosamine hazard may exist for particular species exposed to thiram associated with nitrites or even nitrates if algae are present. |
| Signs and Symptoms | Confusion. Cough. Dizziness. Headache. Sore throat.Redness.Redness. Pain.See Inhalation.irritation eyes, skin, mucous membranedermatitisAntabuse-like effects |
| ICSC Environmental Data | The substance is very toxic to aquatic organisms. Avoid release to the environment in circumstances different to normal use. |
| EPA IRIS Information | ThiramNervous5 x 10 ^-3 mg/kg-day |
| Medical Surveillance | Placement and periodic medical examinations should give special attention to history of skin allergy, eye irritation, and significant respiratory, liver, or kidney disease. SRP: Special counseling for employees with history of heavy alcohol ingestion regarding potential exposure to thiram. |
| RCRA requirements | U244As stipulated in 40 CFR 261.33, when thiram, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5). |
| TSCA requirements | Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Thiram is included on this list. |
| FIFRA requirements | Tolerances for residues of the fungicide thiram (tetramethyl thiuram disulfide) in or on raw agricultural commodities are established as follows: apple, peach, and strawberry.The Agency has completed its assessment of the dietary, occupational, residential, and ecological risk associated with the use of pesticide products containing the active ingredient thiram. Based on a review of these data and on public comments on the Agency's assessments for the active ingredient thiram, the Agency has sufficient information on the human health and ecological effects of thiram to make decisions as part of the tolerance reassessment process under FFDCA and reregistration process under FIFRA, as amended by FQPA. The Agency has determined that thiram containing products are eligible for reregistration provided that: (i) current data gaps and confirmatory data needs are addressed(ii) the risk mitigation measures outlined in this document are adoptedand (iii) label amendments are made to reflect these measures.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Thiram is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA, as amended in 1988. Case No: 0122Pesticide type: fungicideRegistration Standard Date: 06/29/84Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.Active ingredient (AI): ThiramData Call-in (DCI) Date(s): 09/16/91, 03/03/95, 10/13/95AI Status: The producers of the pesticide has made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner. |
| CERCLA reportable quantities | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| State drinking water guidelines | (FL) FLORIDA 35 ug/L(ME) MAINE 35 ug/L |
| Occupational exposure band (OEB) | B |
| Occupational exposure limit (OEL) | TWA: 5 mg/m3 |
| Personal protective equipment (PPE) | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Water hazard class (WGK) | 3 |
| Immediately dangerous to life or health concentration | 100 mg/m3 |
| TSCA inventory status | TSCA listed |
| RTECS number | JO1400000 |
| UN transport number | UN 2771/2811 |
| Customs code | 29303000 |
| Toxicity | LD50 orally in rats: 640 mg/kg (Gaines) |
| Risk statements (R) | 20/22-36/38-43-48/22-50/53 |
| Signal word | Danger |
| GHS pictogram | GHS07,GHS08,GHS09 |
| Hazard symbols | Xn,N |
| Safety statements (S) | 26-36/37-60-61 |
| Hazard class | 9Acute Tox. 4 InhalationAcute Tox. 4 OralAquatic Acute 1Aquatic Chronic 1Eye Irrit. 2Skin Irrit. 2Skin Sens. 1STOT RE 2 Oral |
| Storage class | 13 - Non Combustible Solids |
| Packing group | III |
| GHS hazard statements | H302+H332-H315-H319-H361-H372-H370-H317-H340-H410 |
| Limited quantities | 5.0 kg (11 lbs) (solid) |
| Excepted quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
| REACH registrations | Active |
| Autoignition temperature | 316 °F |
| GHS precautionary statements | P501-P273-P272-P260-P270-P202-P201-P271-P264-P280-P302+P352-P391-P337+P313-P305+P351+P338-P308+P311-P362+P364-P333+P313-P301+P312+P330-P304+P340+P312-P405 |
| Hazardous substances data | 137-26-8(Hazardous Substances Data) |
Applications & Uses
Uses
1. Tetramethylthiuram Disulfide belongs to protective fungicides of broad spectrum, with a residual effect period of up to 7d or so. It is mainly used for dealing with seeds and soil and preventing powdery mildew, smut and rice seedlings damping-off of cereal crops. It can also be used for some fruit trees and vegetable diseases. For example, dressing seed with 500g of 50% wettable powder can control rice blast, rice leaf spot, barley and wheat smut. 2. As pesticides, Tetramethylthiuram Disulfide is often referred to as thiram and is mainly used for the treatment of seeds and soil and the prevention and controlling of cereal powdery mildew, smut and vegetable diseases. This product, as the super accelerator of natural rubber, synthetic rubber and latex, is often referred to as accelerator TMTD and is the representative of thiuram vulcanization accelerator, accounting for 85% of the total amount of similar products. Accelerator T is also the super accelerator of natural rubber, diene synthetic rubber, Ⅱ, R and EPDM, with the highest utilization rate of all. The vulcanization promoting force of accelerator T is very strong, but, without the presence of zinc oxide, it is not vulcanized at all. 3. Used for the manufacture of cables, wires, tires and other rubber products. 4. Used as the super accelerator of natural rubber, synthetic rubber and latex. 5. Used as the late effect promoter of natural rubber, butadiene rubber, styrene-butadiene rubber and polyisoprene rubber. 6. Used for the pest control of rice, wheat, tobacco, sugar beet, grapes and other crops, as well as for the seed dressing and soil treatment. 7. Tetramethylthiuram Disulfide is suitable for the manufacture of natural rubber, synthetic rubber and latex, and can also be used as curing agent. This product is the second accelerator of thiazole accelerators, which can be used with other accelerators as the continuous vulcanization accelerator. 8. In rubber industry, Tetramethylthiuram Disulfide can be used as the super-vulcanization accelerator, and aften used with thiazole accelerator. It can also be used in combination with other accelerators as the continuous rubber accelerator. For slowly decomposing out of free sulfur at more than 100 ℃, it can be used as curing agent too. Its products have excellent resistance to aging and heat, so it is applicable to natural rubber, synthetic rubber and is mainly used in the manufacture of tires, tubes, shoes, cables and other industrial products. In agriculture, it can be used as fungicide and insecticide, and it can also be used as lubricant additives. 9. Production methods from dimethylamine, carbon disulfide, ammonia condensation reaction was dimethyl dithiocarbamate, and then by the oxidation of hydrogen peroxide to the finished product.
Description
Tetramethylthiuram disulfide is a rubber chemieal, an accelerator of vulcanization. It represents the most commonly positive allergen contained in the "thiuram mix". The most frequent occupational categories are the metal industry, homemakers, health services and laboratories, building industries, and shoemakers.
Uses
Thiram is a protective fungicide applied to foliage to control Botrytis spp. on grapes, soft fruit, lettuce, vegetables and ornamentals. It also controls rust on ornamentals, scab and storage diseases on apple and pear and leaf curl and Monilia on stone fruit. It is used in seed treatments alone or in combination with added insecticides or fungicides to control damping off diseases such as Pythium spp., and other diseases like Fusarium spp. of maize, cotton, cereals, legumes, vegetables and ornamentals.
Uses
Tetramethylthiuram disulfide is used as fungicide; bacteriostat; pesticide; rubber vulcanization accelerator; scabicide; seed disinfectant; animal repellent; insecticide; lube-oil additive; wood preservative; in antiseptic sprays; in the blending of lubrieant oils; used against Botrytis, rusts and downy mildews; seed dressing against "damping off' and verticillium wilt; ethanol antagonist and deterrent in mixtures of the methyl, ethyl, propyl, and butyl derivatives; antioxidant in polyolefin plastics; peptizing agent in polysulphide elastomers; in soaps and rodent repellents; nut, fruit, and mushroom disinfectant.
Uses
antianginal
Uses
Thiram is an ectoparasiticide. Thiram is used in agriculture to prevent fungal diseases in seed and crops. Thiram has other applications ranging from use as a topical bactericide to animal repellent.
Uses
Rubber accelerator; vulcanizer; seed disinfectant; fungicide; bacteriostat in soap; animal repellent.
General Description
A liquid solution of a white crystalline solid. Primary hazard is to the environment. Immediate steps should be taken to limit spread to the environment. Easily penetrates the soil to contaminates groundwater and waterways.