Completing data — usually done within a minute
Basic information
- Standard SMILES
CN1C(C(=O)Nc2ccccn2)=C(O)c2sccc2S1(=O)=O- InChIKey
LZNWYQJJBLGYLT-UHFFFAOYSA-N- Molecular formula
- C13H11N3O4S2
- Average molar mass
- 337.382 g/mol
- Monoisotopic mass
- 337.01909783
Names & identifiers
- Preferred name
- Tenoxicam
- IUPAC
- 4-Hydroxy-2-methyl-1,1-dioxo-N-(pyridin-2-yl)-1,2-dihydro-1lambda~6~-thieno[2,3-e][1,2]thiazine-3-carboxamide
- English name
- Tenoxicam
- Molecular formula
- C13H11N3O4S2
- Molecular weight
- 337.37
Names & synonyms
Tenoxicam CRSLornoxicam Impurity 44SoralLimanDo1menDolmenAlganexTilatiltilcotilMOBIFLEX
Database identifiers
- CAS
59804-37-4- PubChem CID
- 54677971
- DTXSID
DTXSID8045486- ChEMBL
CHEMBL302795、CHEMBL3188633- ChEBI
CHEBI:32192- UNII
- Z1R9N0A399
- EC Number
- 620-500-8
Properties
Physicochemical properties
- Melting point
- 209 · 209-2130C (dec)
- Density
- 1.4737 · 1.4737 (rough estimate)
- refractive index
- 1.639 · 1.6390 (estimate)
- storage temp.
- 2 · 2-8°C
- solubility
- Practically insoluble in water, sparingly soluble in methylene chloride, very slightly soluble in anhydrous ethanol. It dissolves in solutions of acids and alkalis.
- pka
- 1 · pKa1 5.3, pKa2 1.1(at 25℃)
- form
- Solid
- color
- White to Yellow to Green
- Water Solubility
- 61.9 mg/L · 61.9mg/L(32 ºC)
- Major Application
- pharmaceuticalpharmaceutical small molecule
- InChI
- InChI=1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
- InChIKey
- LZNWYQJJBLGYLT-UHFFFAOYSA-N
- SMILES
- S1(=O)(=O)C2C=CSC=2C(O)=C(C(NC2=NC=CC=C2)=O)N1C
- CAS DataBase Reference
- 59804 · 59804-37-4
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 1 R9N0A399 · Z1R9N0A399
- ATC code
- 1 AC02 · M01AC02
- UNSPSC Code
- 41116107 · 41116107
- NACRES
- 77 · NA.77
- Protein binding
- 99 % · 99%
- Excreted unchanged in urine
- 1 · <1 (67% as metabolites and unchanged drug)
- Volume of distribution
- 10 · 10-12 Litres
- Biological half-life
- 72 · 72 / -
- Symbol(GHS)
- 6 · GHS06
- Signal word
- Danger
- Hazard statements
- 301 · H301+H311+H331
- Precautionary statements
- 280 · P280-P301+P310+P330-P302+P352+P312-P304+P340+P311
- Hazard Codes
- T,Xi
- Risk Statements
- 23 · 23/24/25-36/37/38
- Safety Statements
- 36 · 36/37/39-45-36-26-36/37
- RIDADR
- 2811 · UN 2811 6.1/PG 3
- WGK Germany
- 2 · 2
- RTECS
- 9095060 · XJ9095060
- HS Code
- 2934.99 · 2934.99.3000
- HazardClass
- 6.1 · 6.1
- Storage Class
- 6.1 C · 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- 3 DermalAcute · Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 Oral
Safety & regulation
Safety data
- wgk
- 2
- rtecs
- XJ9095060
- ridadr
- UN 2811 6.1/PG 3
- hs_code
- 2934.99.3000
- risk_code
- 23/24/25-36/37/38
- Signal word
- Danger
- Symbol(GHS)
- GHS06
- hazard_code
- T,Xi
- safety_code
- 36/37/39-45-36-26-36/37
- hazard_class
- 6.1
- Storage Class
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard statements
- H301+H311+H331
- Hazard Classifications
- Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 Oral
- Precautionary statements
- P280-P301+P310+P330-P302+P352+P312-P304+P340+P311
Chemistry & industry
Applications
DescriptionTenoxicam is a non-steroidal antiinflammatory agent with a profile similar to related piroxicam and now withdrawn isoxicam (55). It is useful in the treatment of rheumatoid arthritis, osteoarthritis and related disorders.
UsesTenoxicam has been used: as a non-steroidal anti-inflammatory agent (NSAID) to study its effects on root gravitropism in Arabidopsis thaliana as a standard in microanalysis of NSAIDs by spectrophotometry to test its effect on surface potential andmembrane fluidity modification in phosphoglyceride monolayers
Upstream & downstream products
Upstream raw materials
Suppliers50 total
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Additional notes
DefinitionChEBI: Tenoxicam is a thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for the treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis. It is also indicated for short term treatment of acute musculoskeletal disorders including strains, sprains and other soft-tissue injuries. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It is a heteroaryl hydroxy compound, a monocarboxylic acid amide, a member of pyridines and a thienothiazine.
Related reactions
1 records
Linked notes
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