Basic information
- Standard SMILES
[Cl][Pd][Cl].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1- InChIKey
YNHIGQDRGKUECZ-UHFFFAOYSA-L- Molecular formula
- C36H30Cl2P2Pd
- Average molar mass
- 701.9 g/mol
Overview
trans-Dichlorobis-(triphenylphosphine) palladium(II) is a chemical compound of palladium. Palladium is a chemical element with the chemical symbol Pd and an atomic number of 46. It is found as a free metal alloyed with gold and other platinum group metals and in the rare minerals cooperite and polarite. (L794)
Names & identifiers
- Preferred name
- Dichlorobis(triphenylphosphine)palladium
- IUPAC
- dichloropalladium;bis(triphenylphosphane)
Names & synonyms
13965-03-2Dichlorobis(triphenylphosphine)palladiumEINECS 237-744-2NSC 122924RefChem:133048237-744-2Dichlorobis(triphenylphosphine)palladium(II)Bis(triphenylphosphine)palladium(II) dichloridebis(triphenylphosphine)palladium(ii) chloridePALLADIUM, DICHLOROBIS(TRIPHENYLPHOSPHINE)-MFCD00009593trans-dichlorobis(triphenylphosphine)palladium(ii)
Show more names
bis(triphenylphosphine)palladium(ii)chloridePDCL2(PPH3)2dichloropalladium;triphenylphosphaneBis(triphenylphosphine)dichloropalladium28966-81-6Dichlorobis(triphenylphosphine) Palladium (II)Palladium(II)bis(triphenylphosphine) dichloridebis(triphenylphosphine) palladiuml(ii) dichloride
Database identifiers
- CAS
13965-03-2- PubChem CID
- 6102075
- EC Number
- 237-744-2
Properties
Computed structural properties
- Topological polar surface area
- 0 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 0
- Rotatable bonds
- 6
- Heavy atoms
- 41
- Formal charge
- 0
- Complexity
- 204
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 19.7% (46 of 233) of reports.
Warning
H302 (18.5%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 233 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Status: Active Update: 11-01-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/18826
Bis(triphenylphosphine)palladium (II) chloride: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesAcute Tox. 4 (18.5%)
Toxicology
Health EffectsContact with palladium may cause palladium sensitivity and allergy. Animal studies have shown that palladium may damage the liver and kidney. (L798)
Toxicity Summary
Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, and interact with functional groups of macromolecules, such as proteins or DNA. Palladium complexes binding to DNA and RNA leads to strand breakage. Palladium ions are able to inhibit most major cellular functions, including DNA and RNA synthesis. Palladium compounds have been shown to bind to and inhibit various enzymes, including creatine kinase and prolyl hydroxylase. (L798)
Signs and SymptomsSkin contact with palladium may cause contact dermatitis, erythema, and oedema. (L798)
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Chemistry & industry
Pharmacology
Metabolism/Metabolites
Palladium may be absorbed through oral, dermal, and inhalation exposure. Once in the body it distributes to the kidney, liver, spleen, lymph nodes, adrenal gland, lung and bone. Palladium's ability to form complexes allows it the bind to amino acids, proteins, DNA, and other macromolecules. Palladium and its metabolites are excreted in the urine and faeces. (A21)
Related reactions
1,428 records
Linked notes
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