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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 6321425Generated: October 23, 2026

Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-

Ivermectin B1b · Component B1b · IvermectinH2B1b · avermectin H2B1b · Dihydroavermectin B1b · 22,23-Dihydroavermectin B1b · 22,23- dihydroavermectin B1b (Ivermectin B1b) · 22,23-Dihydro-34-nor-5-O-demethylavermectin A1a

https://huagongshe.com/en/chemical/6321425

Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)- molecular structure

Identifiers & Physical Properties

CAS No.70209-81-3
Molecular formulaC47H72O14
Average molar mass861.1 g/mol
Monoisotopic mass860.49220698 g/mol
SMILESCO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@]54O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O
InChIKeyVARHUCVRRNANBD-PVVXTEPVSA-N
PubChem CID6321425
ChEBICHEBI:63943
EC No.274-384-5
DTXSIDDTXSID3023182

Chemical & Physical Properties

XLogP3.8
Topological polar surface area170
Hydrogen bond donors3
Hydrogen bond acceptors14
Rotatable bonds7
Heavy atoms61
Formal charge0
Complexity1,660
Boiling point934.1±65.0 °C(Predicted)
Density1.24±0.1 g/cm3(Predicted)
Storage conditionsStore at -20°C
SolubilityDMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
Physical stateA solid
pKa (acidity coefficient)12.42±0.70(Predicted)
ColorWhite to off-white
StabilityTemperature sensitive
InChIKeyVARHUCVRRNANBD-PVVXTEPVSA-N
FDA UNII0W28CYI3TU
UN transport number2588
Hazard class6.1(a)
Packing groupII

Safety & Regulations

Regulatory informationAvermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
UN transport number2588
Hazard class6.1(a)
Packing groupII

Applications & Uses

Uses

Ivermectin B1b is a minor component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.

Uses

Ivermectin B1b (dihydroavermectin B1b) is the minor component (