Chlorotrimethylsilane
TMSCL · 75-77-4 · CSI · TMCS · TRIMETHYLSILYL CHLORIDE · TRIMETHYLCHLOROSILANE · tmsci · (CH3)3SiCl
Identifiers & Physical Properties
| CAS No. | 75-77-4 |
|---|---|
| Molecular formula | C3H9ClSi |
| Average molar mass | 108.64 g/mol |
| Monoisotopic mass | 108.0162045 g/mol |
| SMILES | C[Si](C)(C)Cl |
| InChIKey | IJOOHPMOJXWVHK-UHFFFAOYSA-N |
| PubChem CID | 6397 |
| ChEMBL | CHEMBL1505385 |
| ChEBI | CHEBI:85069 |
| EC No. | 200-900-5 |
| DTXSID | DTXSID2024822 |
Chemical & Physical Properties
| Topological polar surface area | 0 |
|---|---|
| Hydrogen bond donors | 0 |
| Hydrogen bond acceptors | 0 |
| Rotatable bonds | 0 |
| Heavy atoms | 5 |
| Formal charge | 0 |
| Complexity | 28 |
| Melting point | −40 °C(lit.) |
| Boiling point | 57 °C(lit.) |
| Density | 0.857 g/mL at 25 °C |
| Vapor density | 3.7 (vs air) |
| Vapor pressure | 100 mm Hg ( 25 °C) |
| Refractive index | n20/D 1.500 |
| Flash point | 104 °F |
| Storage conditions | Store below +30°C. |
| Solubility | Miscible with ether, benzene, diethylether and perchloroethylene.REACTS |
| Physical state | Liquid |
| Specific gravity | 0.8536 (27℃) |
| Color | Clear colorless |
| Explosive limits | 1.5-46%(V) |
| Sensitivity | Moisture Sensitive |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| BRN | 1209232 |
| Stability | Stable. Highly flammable - note low flash point. Reacts violently with water. Incompatible with water, moisture, strong oxidizing agents, strong acids, strong bases, aldehydes, alcohols, amines, esters, ketones. |
| InChI | 1S/C3H9ClSi/c1-5(2,3)4/h1-3H3 |
| InChIKey | IJOOHPMOJXWVHK-UHFFFAOYSA-N |
| SMILES | C[Si](C)(C)Cl |
| CAS DataBase Reference | 75-77-4(CAS DataBase Reference) |
| FDA UNII | 62UO4690X6 |
| NIST Chemistry Reference | Silane, chlorotrimethyl-(75-77-4) |
| EPA Substance Registry System | Trimethylchlorosilane (75-77-4) |
| UNSPSC Code | 12352302 |
| NACRES | NA.22 |
| GHS pictogram | GHS02,GHS05,GHS06,GHS08 |
| Signal word | Danger |
| GHS hazard statements | H301+H331-H312-H314-H371-H225-H290 |
| GHS precautionary statements | P501-P270-P240-P260-P210-P233-P234-P243-P241-P242-P271-P264-P280-P370+P378-P390-P308+P311-P362+P364-P303+P361+P353-P301+P330+P331-P301+P310+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P403+P235-P406-P405 |
| Personal protective equipment (PPE) | Faceshields, Gloves, Goggles |
| Hazard symbols | T,F,C,Xn |
| Risk statements (R) | 20/21-36/38-34-21-14-11-37-35-19-40-10-67-20/21/22-52 |
| Safety statements (S) | 26-36/37/39-45-16-36/37-7/9 |
| UN transport number | UN 1298 |
| Water hazard class (WGK) | 2 |
| RTECS number | VV2710000 |
| F | 10-21 |
| Autoignition temperature | 752 °F |
| Hazard Note | Highly Flammable/Corrosive/Moisture Sensitive |
| TSCA inventory status | TSCA listed |
| Hazard class | 3Acute Tox. 3 InhalationAcute Tox. 3 OralAcute Tox. 4 DermalEye Dam. 1Flam. Liq. 2Skin Corr. 1A |
| Packing group | II |
| Customs code | 29310095 |
| Storage class | 3 - Flammable liquids |
| Hazardous substances data | 75-77-4(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 4868 mg/kg LD50 dermal Rabbit 1530 mg/kg |
| REACH registrations | Active |
| Excepted quantities | Not Permitted as Excepted Quantity |
Safety & Regulations
| F | 10-21 |
|---|---|
| Personal protective equipment (PPE) | Faceshields, Gloves, Goggles |
| Water hazard class (WGK) | 2 |
| TSCA inventory status | TSCA listed |
| RTECS number | VV2710000 |
| UN transport number | UN 1298 |
| Customs code | 29310095 |
| Toxicity | LD50 orally in Rabbit: 4868 mg/kg LD50 dermal Rabbit 1530 mg/kg |
| Risk statements (R) | 20/21-36/38-34-21-14-11-37-35-19-40-10-67-20/21/22-52 |
| Signal word | Danger |
| GHS pictogram | GHS02,GHS05,GHS06,GHS08 |
| Hazard symbols | T,F,C,Xn |
| hazard_note | Highly Flammable/Corrosive/Moisture Sensitive |
| Safety statements (S) | 26-36/37/39-45-16-36/37-7/9 |
| Hazard class | 3Acute Tox. 3 InhalationAcute Tox. 3 OralAcute Tox. 4 DermalEye Dam. 1Flam. Liq. 2Skin Corr. 1A |
| Storage class | 3 - Flammable liquids |
| Packing group | II |
| GHS hazard statements | H301+H331-H312-H314-H371-H225-H290 |
| Excepted quantities | Not Permitted as Excepted Quantity |
| REACH registrations | Active |
| Autoignition temperature | 752 °F |
| GHS precautionary statements | P501-P270-P240-P260-P210-P233-P234-P243-P241-P242-P271-P264-P280-P370+P378-P390-P308+P311-P362+P364-P303+P361+P353-P301+P330+P331-P301+P310+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P403+P235-P406-P405 |
| Hazardous substances data | 75-77-4(Hazardous Substances Data) |
Applications & Uses
Description
Chlorotrimethylsilane is a valuable reagent for the protection of the hydroxyl function in organic synthesis. It should be distilled from calciumhydride (or tributylamine) under nitrogen before use,and stored and weighed under nitrogen. Use of the reagent without purification has been reported to lead to explosions. Chlorotrimethylsilane may contain dichlorodimethylsilane as an impurity. This may be removed before distillation by very cautious treatment with a small amount of water，which hydrolyses the dichloro compound more rapidly. Excess chlorotrimethylsilane in a reaction mixture may be destroyed by the very careful addition of aqueous sodium hydrogencarbonate solution.
Uses
Chlorotrimethylsilane is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis, and used for silylation and as a protection group in the process of various organic synthesis. It is used in the production of trimethylsilyl halides, pseudohalides and various organic silicon compounds. It is also used to produce hexamethyldisilane by reduction.
General Description
Trimethylchlorosilane appears as a colorless fuming liquid with a pungent odor. Boiling point 135° F, Flash point -18°F. Density 0.854g/cm3. The vapor and liquid may cause burns. Vapors are heavier than air.