Levodropropizine

HCID 65859CAS 99291-25-5
Substructure searchFind similar structures

Basic information

Standard SMILES
OC[C@@H](O)CN1CCN(c2ccccc2)CC1
InChIKey
PTVWPYVOOKLBCG-ZDUSSCGKSA-N
Molecular formula
C13H20N2O2
Average molar mass
236.31 g/mol
Monoisotopic mass
236.15247788

Overview

Levodropropizine is a member of the class of N-arylpiperazines that is N-phenylpiperazine in which the amino hydrogen is replaced by a 2,3-dihydroxypropyl group (the S-enantiomer). A peripherally acting antitussive drug that is used as an alternative to opioids. It has a role as an antitussive. It is a secondary alcohol, a N-alkylpiperazine and a N-arylpiperazine.

Names & identifiers

Preferred name
Levodropropizine
IUPAC
(2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol
English name
Levodropropizine
Molecular formula
C13H20N2O2
Molecular weight
236.31

Names & synonyms

Levodropropizine99291-25-5LevotussDanka(-)-DropropizineLevdropropizine(S)-(-)-DropropizineRapituxLevodropropizinaLevodropropizinumLevoprontL-dropropizine
Show more names
LVDPDF-526LevodropizinelivodropropizineLevodropropazine.
Dropropizine, (s)-3O31P6T4G3(-)-(S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediolDTXSID8023210CHEBI:82722Levdropropizinadipropizine, (S)-RefChem:153202

Database identifiers

CAS
99291-25-5
PubChem CID
65859
DTXSID
DTXSID8023210
ChEMBL
CHEMBL1288810
ChEBI
CHEBI:82722
UNII
3O31P6T4G3
EC Number
640-087-8
Nikkaji
J276.144K

Properties

Computed structural properties

XLogP
0.6
Topological polar surface area
46.9 Ų
Hydrogen bond donors
2
Hydrogen bond acceptors
4
Rotatable bonds
4
Heavy atoms
17

Experimental & physicochemical properties

DrugsPharmaceuticals -> Listed in ZINC15

Physicochemical properties

Melting point
98 · 98-100°C
Boiling point
412.7 · 412.7±34.0 °C(Predicted)
Density
1.168 · 1.168±0.06 g/cm3(Predicted)
storage temp.
Keep in dark place,Inert atmosphere,Room temperature
solubility
Slightly soluble in water, freely soluble in dilute acetic acid and in methanol, slightly soluble in ethanol (96 per cent).
pka
14.21 · 14.21±0.20(Predicted)

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 10 reports by companies from 1 notifications to the ECHA C&L Inventory.

Hazard information

Hazard Classes and CategoriesAcute Tox. 4 (100%)

Safety data

wgk
WGK 3
hs_code
2933.59.5300
Signal word
Warning
Symbol(GHS)
GHS07
Storage Class
11 - Combustible Solids
Hazard statements
H302

Chemistry & industry

Pharmacology

ATC Code · 3 items

R05DB27

R - Respiratory system

QR - Respiratory system

MeSH Pharmacological ClassificationAgents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.

Applications

UsesCough Suppressant

UsesS-Form of Dropropizine. Cough suppressive phenylpiperazine derivative. Antitussive.

Suppliers50 total

北京华美互利生物化工010-56205725 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
上海策嵘生物科技有限公司[email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
湖北威德利化学试剂有限公司181-6332-1995 18062128043 · [email protected]
Additional notes · 1 item

DefinitionChEBI: A member of the class of N-arylpiperazines that is N-phenylpiperazine in which the amino hydrogen is replaced by a 2,3-dihydroxypropyl group (the S-enantiomer). A peripherally acting antitussive drug t at is used as an alternative to opioids.

Related reactions

1 records
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Linked notes

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