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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 77955Generated: October 23, 2026

2-Naphthalenecarboxamide, N-(4-chloro-2,5-dimethoxyphenyl)-3-hydroxy-

N-(4-chloro-2,5-dimethoxyphenyl)-3-hydroxy-2-naphthamide · C.I. 37555 · Conazoic BC · Naftol AS-LC · Azoic C.C.23 · NAPHTOL AS-LC · NAPTHOL AS-LC · Anarthol AS-LC

https://huagongshe.com/en/chemical/77955

2-Naphthalenecarboxamide, N-(4-chloro-2,5-dimethoxyphenyl)-3-hydroxy- molecular structure

Identifiers & Physical Properties

CAS No.4273-92-1
Molecular formulaC19H16ClNO4
Average molar mass357.8 g/mol
Monoisotopic mass357.07678567 g/mol
SMILESCOc1cc(NC(=O)c2cc3ccccc3cc2O)c(OC)cc1Cl
InChIKeyQIHKTBRNOLQDGQ-UHFFFAOYSA-N
PubChem CID77955
ChEMBLCHEMBL1456848
EC No.224-270-6
DTXSIDDTXSID8063385

Chemical & Physical Properties

XLogP4.8
Topological polar surface area67.8
Hydrogen bond donors2
Hydrogen bond acceptors4
Rotatable bonds4
Heavy atoms25
Formal charge0
Complexity463
Melting point190°C
Boiling point479.8±45.0 °C(Predicted)
Density1.371±0.06 g/cm3(Predicted)
Vapor pressure0-0Pa at 25℃
Storage conditionsSealed in dry,Room Temperature
SolubilityChloroform (Slightly, Heated), DMSO (Slightly)
pKa (acidity coefficient)8.65±0.40(Predicted)
Physical stateSolid
ColorPale Grey to Light Grey
LogP (partition coefficient)2.85 at 23℃ and pH7.1
EPA Substance Registry System2-Naphthalenecarboxamide, N-(4-chloro-2,5-dimethoxyphenyl)-3-hydroxy- (4273-92-1)
GHS pictogramGHS07
Signal wordWarning
GHS hazard statementsH317
GHS precautionary statementsP261-P272-P280-P302+P352-P333+P313-P321-P363-P501
TSCA inventory statusTSCA listed
REACH registrationsActive

Safety & Regulations

GHS classificationThis chemical does not meet GHS hazard criteria for 33.3% (2 of 6) of reports.WarningH317 (66.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 6 reports by companies from 2 notifications to the ECHA C&L Inventory.
Regulatory informationChemical: 2-Naphthalenecarboxamide, N-(4-chloro-2,5-dimethoxyphenyl)-3-hydroxy-REACH registered substance: 4'-chloro-3-hydroxy-2',5'-dimethoxy-2-naphthanilide (EC: 224-270-6)
Hazard Classes and CategoriesSkin Sens. 1A (66.7%)
TSCA inventory statusTSCA listed
Signal wordWarning
GHS pictogramGHS07
GHS hazard statementsH317
REACH registrationsActive
GHS precautionary statementsP261-P272-P280-P302+P352-P333+P313-P321-P363-P501

Applications & Uses

Uses

NaphtholaS-LC can be used for aqueous inkjet set and inkjet printing.

Preparation & Synthesis

Preparation

Naphthol AS-LC is synthesized by 4-Chloro-2,5-dimethoxybenzenamine and 3-Hydroxy-2-naphthoic acid condensation.