HuagongsheHuagongshe Chemistry Print Report · For research reference only
Vinyl cyclohexene dioxide
VCD · VINYLCYCLOHEXENE DIOXIDE · 4-VINYL-1-CYCLOHEXENE DIEPOXIDE · 7-oxabicyclo[4.1.0]heptane,3-oxiranyl- · 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane · VCHD · ep-206 · ERL 4206
Identifiers & Physical Properties
| CAS No. | 106-87-6 |
|---|---|
| Molecular formula | C8H12O2 |
| Average molar mass | 140.18 g/mol |
| Monoisotopic mass | 140.08372962 g/mol |
| SMILES | C1CC2OC2CC1C1CO1 |
| InChIKey | OECTYKWYRCHAKR-UHFFFAOYSA-N |
| PubChem CID | 7833 |
| ChEMBL | CHEMBL1734307 |
| ChEBI | CHEBI:59001 |
| EC No. | 203-437-7 |
| DTXSID | DTXSID0020604 |
Chemical & Physical Properties
| XLogP | 0.8 |
|---|---|
| Topological polar surface area | 25.1 |
| Hydrogen bond donors | 0 |
| Hydrogen bond acceptors | 2 |
| Rotatable bonds | 1 |
| Heavy atoms | 10 |
| Formal charge | 0 |
| Complexity | 157 |
| LogP (partition coefficient) | 1.3 |
| Density | 1.0986 at 68 °F (NTP, 1992) - Denser than waterwill sink1.0986 @ 20 °C/20 °CRelative density (water = 1): 1.101.0991.0966 @ 20°C1.094 g/mL at 25 °C(lit.) |
| Viscosity | 7.77 CP @ 20 °C |
| Color/Form | COLORLESS LIQUIDColorless liquid. |
| Solubility | 50 to 100 mg/mL at 72 °F (NTP, 1992)SOL IN WATERSolubility in water, g/100ml at 20 °C: 18.3High154.7g/L(20 ºC) |
| Flash point | 230 °F (NTP, 1992)110 °C o.c.230 °F (open cup)(oc) 230 °F225 °F |
| Boiling point | 441 °F at 760 mmHg (NTP, 1992)227 °C @ 760 MM HG227 °C @760 [mm Hg]230-232 °C(lit.) |
| Melting point | less than -67 °F (NTP, 1992)LESS THAN -55 °C<-67 °F-164 °F-55°C |
| Vapor density | 4.07 (NTP, 1992) - Heavier than airwill sink (Relative to Air)Relative vapor density (air = 1): 4.8 |
| Vapor pressure | 0.1 mmHg at 68 °F (NTP, 1992)1.17 [mmHg]LESS THAN 0.1 MM HG @ 20 °CVapor pressure, kPa at 20 °C: |
| Refractive index | INDEX OF REFRACTION: 1.4787 @ 20 °Cn20/D 1.477(lit.) |
| Physical Description | 1-vinyl-3-cyclohexene dioxide is a clear colorless liquid. Sets to glass at -67 °F. Faint olefinic odor. (NTP, 1992)[NIOSH]COLOURLESS LIQUID.Colorless liquid. |
| Storage conditions | under inert gas (nitrogen or Argon) at 2-8°C |
| Physical state | Colorless or pale yellow liquid |
| Color | Colorless to light yellow |
| BRN | 106071 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, alcohols, amines and other compounds containg an active hydrogen. Hydrolyzes slowly in water. |
| InChI | InChI=1S/C8H12O2/c1-2-6-7(10-6)3-5(1)8-4-9-8/h5-8H,1-4H2 |
| InChIKey | OECTYKWYRCHAKR-UHFFFAOYSA-N |
| SMILES | C12C(O1)CCC(C1CO1)C2 |
| Toxicology and Carcinogenesis | Toxicology and Carcinogenesis Studies of 4-Vinyl-1-cyclohexene Diepoxide (CASRN 106-87-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies) |
| CAS DataBase Reference | 106-87-6(CAS DataBase Reference) |
| FDA UNII | 596C064IG4 |
| Proposition 65 List | Vinyl cyclohexene dioxide (4-vinyl-1-cyclohexene diepoxide) |
| IARC | 2B (Vol. Sup 7, 60) 1994 |
| EPA Substance Registry System | 4-Vinylcyclohexene diepoxide (106-87-6) |
| UNSPSC Code | 12162002 |
| NACRES | NA.25 |
| GHS pictogram | GHS06,GHS08 |
| Signal word | Danger |
| GHS hazard statements | H301+H311+H331-H351 |
| GHS precautionary statements | P201-P280-P301+P310+P330-P302+P352+P312-P304+P340+P311 |
| Personal protective equipment (PPE) | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter |
| Hazard symbols | T |
| Risk statements (R) | 23/24/25-68/20/21/22-68 |
| Safety statements (S) | 23-24-45 |
| UN transport number | UN 2810 6.1/PG 3 |
| Occupational exposure band (OEB) | A |
| Occupational exposure limit (OEL) | TWA: 10 ppm (60 mg/m3) [skin] |
| Water hazard class (WGK) | 1 |
| RTECS number | RN8640000 |
| TSCA inventory status | TSCA listed |
| Hazard class | 6.1(b)Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 4 OralCarc. 1BMuta. 2Repr. 1B |
| Packing group | III |
| Storage class | 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects |
| Hazardous substances data | 106-87-6(Hazardous Substances Data) |
Safety & Regulations
| GHS classification | DangerH302: Harmful if swallowed [Warning Acute toxicity, oral]H331: Toxic if inhaled [Danger Acute toxicity, inhalation]H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]H350: May cause cancer [Danger Carcinogenicity]H360F: May damage fertility [Danger Reproductive toxicity]P203, P261, P264, P270, P271, P280, P301+P317, P304+P340, P316, P318, P321, P330, P403+P233, P405, and P501 (click each P-code to see the statement) |
|---|---|
| Regulatory information | Chemical: 7-Oxabicyclo[4.1.0]heptane, 3-oxiranyl-Hazard Traits - CarcinogenicityReproductive ToxicityAuthoritative List - EC Annex VI CMRs - Cat. 1BIARC Carcinogens - 2BNTP RoC - reasonableProp 65Report - regardless of intended function of ingredient in the productVinyl cyclohexene dioxide: HSNO Approval: HSR003101 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| Other safety information | IMAP assessments - Epoxidised cycloaliphatic olefins: Human health tier II assessmentIMAP assessments - 7-Oxabicyclo[4.1.0]heptane, 3-oxiranyl-: Environment tier I assessment |
| DOT label | Poison |
| Fire hazards | This chemical is combustible. (NTP, 1992)Combustible. Risk of fire and explosion on contact with acids or bases. |
| Fire potential | Slight, when exposed to heat or flame. |
| Health hazards | Excerpt from NIOSH Pocket Guide for Vinyl cyclohexene dioxide:Exposure Routes: Inhalation, skin absorption, ingestion, skin and/or eye contactSymptoms: In Animals: irritation eyes, skin, respiratory systemtesticular atrophyleukopenia (reduced blood leukocytes), necrosis thymusskin sensitization[potential occupational carcinogen]Target Organs: Eyes, skin, respiratory system, blood, thymus, reproductive systemCancer Site: [in animals: skin tumors] (NIOSH, 2024) |
| Hazards summary | A potential skin sensitizer[HSDB] VCD causes male and female reproductive damage in high-dose animal studies. [ACGIH] May cause respiratory tract irritation and pulmonary edemaMay cause kidney injury[ICSC] |
| Reactive group | EpoxidesPolymerizable Compounds |
| EC classification | Symbol: TR: 23/24/25-68S: (1/2)-23-24-45 |
| UN classification | UN Hazard Class: 6.1 |
| Special Reports | National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. 4-Vinyl-1-cyclohexene Diepoxide (106-87-6) is listed as reasonably anticipated to be a human carcinogen.[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s187vch.pdf]NTP TR No 362Route: skin paintSpecies: rats and mice. NTIS No PB90219957/AS.[NTPDivision of Toxicology Research and TestingManagement Status Report07/22/92p.27] |
| TSCA requirements | Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, use, and exposure to EPA as cited in the preamble of the 51 FR 41329. |
| Fire fighting | Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)Use water spray, powder, alcohol-resistant foam, carbon dioxide. |
| First aid measures | Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention . |
| First aid | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.INHALATION: IMMEDIATELY leave the contaminated areatake deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be usedif not available, use a level of protection greater than or equal to that advised under Protective Clothing.INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)(General first aid procedures)Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.Skin: Water wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and wash the skin with water. If symptoms occur after washing, get medical attention immediately.Breathing: Respiratory supportSwallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. |
| Safe storage | Separated from food and feedstuffs, alcohols, amines and other active hydrogen compounds. Dry. Ventilation along the floor. |
| Fire fighting procedures | To fight fire: Water, foam, dry chemical. |
| Nonfire spill response | SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and protect it from moisture. (NTP, 1992) |
| Spillage disposal | Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable containers. Wash away remainder with plenty of water. |
| Preventive Measures | The worker should immediately wash the skin when it becomes contaminated.Work clothing that becomes wet or significantly contaminated should be removed and replaced. |
| Isolation and Evacuation | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directionsalso, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024) |
| Eye Prevention | Wear face shield or eye protection in combination with breathing protection. |
| Fire Prevention | NO open flames. |
| Inhalation Risk | A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C. |
| Cancer Sites | [in animals: skin tumors] |
| Target organs | Eyes, skin, respiratory system, blood, thymus, reproductive system |
| Adverse effects | Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.Skin Sensitizer - An agent that can induce an allergic reaction in the skin.Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.NTP Carcinogen - Reasonably anticipated to be a human carcinogen.ACGIH Carcinogen - Confirmed Animal. |
| Exposure routes | The substance can be absorbed into the body by inhalation, through the skin and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contact |
| Signs and Symptoms | Cough. Laboured breathing. Sore throat.MAY BE ABSORBED! Dry skin. Redness. Pain. Swelling.See Inhalation.In Animals: irritation eyes, skin, respiratory systemtesticular atrophyleukopenia (reduced blood leukocytes), necrosis thymusskin sensitization[potential occupational carcinogen] |
| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=106-87-6] |
| Human Toxicity Excerpts | HUMAN EXPERIENCE INDICATES THAT IT IS MILD TO MODERATE SKIN IRRITANT ... . ONE CASE OF SEVERE VESICULATION OF SKIN OF BOTH FEET WHEN WORKER WORE SHOES PREVIOUSLY CONTAMINATED WITH THIS COMPD.TOXIC BY INGESTION & SKIN ABSORPTION. STRONG IRRITANT TO SKIN & TISSUE.EYE INJURY IS CONSIDERED TO BE DEFINITE HAZARD. IF VAPOR PRESSURE OF 0.1 MM HG AT 20 °C IS CORRECT ... RISK BY INHALATION IS CONSIDERED TO BE SLIGHT. BECAUSE OF VERY LIMITED ... DATA & BECAUSE OF DEMONSTRATED CARCINOGENICITY WHEN ... APPLIED TO SKIN OF MOUSE, EXTREME CAUTION SHOULD BE EXERCISED IN USE OF THIS DIEPOXIDE.Allergic contact dermatitis occurred in an electron microscopist after exposure to the cycloaliphatic epoxy, vinyl cyclohexane diepoxide. Cycloaliphatic epoxies are not based on the diglycidyl ether of bisphenol A, presently the epoxy of greatest commercial usage. Latex or polyvinyl chloride gloves did not protect the reported patient from precutaneous absorption and elicitation of allergic dermatitis.A study of occupational exposure to sensitizing chemicals was conducted. The study was initiated because of numerous complaints of eye, nasal, skin, and respiratory irritation among workers at an industrial facility. Serum samples were obtained from 31 workers and assayed for immunoglobulin G and immunoglobulin E to an unspecified number of chemicals. An enzyme linked immunosorbent assay technique was used to detect the antibodies. Immunoglobulin G and immunoglobulin E antibodies against four chemicals were found: an aliphatic diisocyanate, 4-vinylcyclohexene-dioxide, trimellitic anhydride, and an unknown substance which was a component of n-octyl-n-decyl-trimellitate. The presence or absence of antibodies could not be correlated with the presence or absence of symptomshowever, the highest incidence of symptoms occurred in workers who were classified as having the highest exposures. It was noted that trimellitic anhydride is not known to be present at the facility. The source of the trimellitic anhydride response is not known. It was concluded that there is no occupational allergic disease in the worker population. The lack of correlation between the antibody responses and symptoms suggests that an immunologic factor is not the cause of the reported symptoms. The symptoms are more likely to be due to irritant nonimmunological reactions. |
| Carcinogen Classification | 4-Vinylcyclohexene diepoxideGroup 2B: Possibly carcinogenic to humansVolume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987440 pagesISBN 92-832-1411-0 (out of print)Volume 60: (1994) Some Industrial Chemicals4-Vinyl-1-Cyclohexene Diepoxide |
| Non-Human Toxicity Excerpts | 20 REPEATED SKIN APPLICATIONS TO RABBITS CAUSES SEVERE TO EXTREME IRRITATION.REPEATED SKIN APPLICATIONS OF 16 MG OF A COMMERCIAL SAMPLE OF /VINYLCYCLOHEXENE DIOXIDE/ ... IN ACETONE 5 TIMES WEEKLY FOR 12 MO ... SKIN TUMORS IN 11/20 MALE ALBINO MICE9 ... SQUAMOUS CELL CARCINOMAS &/OR SARCOMAS. ... 1/20 & 4/18 C57B1 OR C3H MICE DEVELOPED SKIN TUMORS AFTER ... 10% SOLN IN ACETONE & TOTAL DOSES OF 70 & 78 MG (CONTROL DATA ... GIVEN FOR NEITHER OF ABOVE STUDIES).OF 30 8 WK OLD MALE SWISS ICR/HA MICE PAINTED ON CLIPPED DORSAL SKIN WITH 0.1 MLOF A 10% SOLN /OF VINYLCYCLOHEXENEDIOXIDE/ IN BENZENE THRICE WEEKLY, 14 DEVELOPED SKIN TUMORS9 ... HAD SQUAMOUS CELL CARCINOMASMEAN SURVIVAL TIME WAS 326 DAYS. AMONG 150 BENZENE-TREATED MICE, SKIN TUMORS ... IN 11, 1 ... SQUAMOUS-CELL ... ./VINYLCYCLOHEXENE DIOXIDE/ CAUSES ACUTE RESP TRACT IRRITATION & CONGESTION OF LUNGS. IT PRODUCES REDNESS & SWELLING COMPATIBLE WITH 1ST DEG BURN ON CLIPPED SKIN OF RABBITS. TREATED RATS SHOWED FOCAL NECROSIS OF THYMUS, & LEUKOCYTE COUNT FELL BY MORE THAN 60% DURING 1ST 4 DAYS. ... TESTICULAR ATROPHY IN SOME ... ANIMALS ... .For more Non-Human Toxicity Excerpts (Complete) data for VINYLCYCLOHEXENE DIOXIDE (20 total), please visit the HSDB record page. |
| Evidence for Carcinogenicity | Evaluation: There is inadequate evidence in humans for the carcinogenicity of 4-vinylcyclohexene diepoxide. There is sufficient evidence in experimental animals for the carcinogenicity of 4-vinylcyclohexene diepoxide. Overall evaluation: 4-Vinylcyclohexene diepoxide is possibly carcinogenic to humans (Group 2B).A3Confirmed animal carcinogen with unknown relevance to humans.4-Vinyl-1-cyclohexene Diepoxide: reasonably anticipated to be a human carcinogen. |
| National Toxicology Program Studies | Two-year studies were conducted by administrating 4-vinyl-1- cyclohexene diepoxide in acetone by dermal application, 5 days per week to groups of 60 rats of each sex at 0, 15, or 30 mg/animal. Groups of 60 mice of each sex were administered 0, 2.5, 5, or 10 mg/animal on the same schedule for 103 weeks. None of the doses selected had produced ulceration of skin in 13 week studies. ... In general, the body weights and survival were lower in mid and high dose groups than in vehicle controls. The survival was lower in exposed groups, primarily because of neoplasms (survival at week 105 male rats: vehicle control, 7/50low dose, 8/50high dose, 4/50female rats: 27/5023/5015/50male micevehicle control 38/50low dose, 35/50mid dose, 4/50high dose, 0/50female mice30/500/50). All high dose male mice died by week 83the 10 surviving high dose female mice were killed during week 85. ... Acanthosis and sebaceous gland hypertrophy of skin from the scapula or back were observed at substantially increased incidences in exposed male and female rats. Squamous cell papillomas in male rats and squamous cell carcinomas in male and female rats were observed only in exposed rats (squamous cell carcinomas--male: vehicle control 0/50low dose 33/50high dose, 36/50female: 0/5016/50). The incidences of basal celladenomas or carcinomas (combined) were increased (male: 0/501/504/50). ... For exposed mice, acanthosis, hyperkeratosis, and necrotizing inflammation of the skin were observed over the scapula or back. Squamous cell carcinomas were found only in exposed mice (male: vehicle control, 0/50low dose, 14/50mid dose, 39/50high dose, 42/5037/5041/50). ... Follicular atrophy and tubular hyperplasia of the ovary in female mice were increased (atrophy: 12/5043/4942/4947/50tubular hyperplasia: 5/5035/4934/50). Mid and high dose females had benign or malignant granulosa cell tumors (0/50The immunotoxic effects of 4-vinyl-1-cyclohexene diepoxide were studied in male B6C3F1 mice after a 5 day dermal exposure at doses ranging from 2.5 to 10 mg/mouse/day. 4-Vinyl-1-cyclohexene diepoxide was immunosuppressive at 10 mg/mouse and, to a lesser extent, at 5 mg/mouse, as indicated by a decrease in peripheral lymphocytes and the in vitro lymphoproliferative response to phytohemagglutinin and concanavalin A in the high dose group and suppression of the antibody plaque-forming-cell response in the 5 and 10 mg/mouse groups.4-Vinyl-1-cyclohexene diepoxide was mutagenic in Salmonella typhimurium strains TA98, TA100, and TA1535 with and without exogenous metabolic activationthe compound was equivocally mutagenic in strain TA1537 without S9 but gave a positive response in the presence of activation. 4-Vinyl-1-cyclohexene diepoxide induced resistance to trifluorothymidine in mouse L5178Y/TK cells without exogenous metabolic activationit was not tested with activation. 4-Vinyl-1-cyclohexene diepoxide induced sister chromatid exchanges and chromosomal aberrations in Chinese hamster ovary cells in the presence and absence of exogenous metabolic activation. |
| Toxicity Data | LC50 (rat) = 800 ppm/4h |
| Occupational exposure band (OEB) | A |
| Occupational exposure limit (OEL) | TWA: 10 ppm (60 mg/m3) [skin] |
| Personal protective equipment (PPE) | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter |
| Water hazard class (WGK) | 1 |
| TSCA inventory status | TSCA listed |
| RTECS number | RN8640000 |
| UN transport number | UN 2810 6.1/PG 3 |
| Risk statements (R) | 23/24/25-68/20/21/22-68 |
| Signal word | Danger |
| GHS pictogram | GHS06,GHS08 |
| Hazard symbols | T |
| Safety statements (S) | 23-24-45 |
| Hazard class | 6.1(b)Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 4 OralCarc. 1BMuta. 2Repr. 1B |
| Storage class | 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects |
| Packing group | III |
| GHS hazard statements | H301+H311+H331-H351 |
| GHS precautionary statements | P201-P280-P301+P310+P330-P302+P352+P312-P304+P340+P311 |
| Hazardous substances data | 106-87-6(Hazardous Substances Data) |
Applications & Uses
Uses
As a chemical intermediate and as a reactive diluent for diepoxides and epoxy resins.
Uses
Vinylcyclohexene dioxide (VCD) may be used to study and understand its effect on ovarian follicles and effects on epithelial differentiation.
Uses
Vinylcyclohexene dioxide (VCD) is used to study toxicity as an ovotoxin,and it's also used to understand its mechanisms of toxicity towards ovarian follicles and effects on epithelial differentiation.
General Description
Clear colorless liquid. Sets to glass at -67°F. Faint olefinic odor.