HuagongsheHuagongshe Chemistry Print Report · For research reference only
Folpet
FOLPAN · n-((trichloromethyl)thio)-phthalimid · Folpel · 2-[(Trichloromethyl)thio]-1H-Isoindole-1,3(2H)-dione · folpe · Ftalan · Folpex · folnit
Identifiers & Physical Properties
| CAS No. | 133-07-3 |
|---|---|
| Molecular formula | C9H4Cl3NO2S |
| Average molar mass | 296.6 g/mol |
| Monoisotopic mass | 294.90283241 g/mol |
| SMILES | O=C1c2ccccc2C(=O)N1SC(Cl)(Cl)Cl |
| InChIKey | HKIOYBQGHSTUDB-UHFFFAOYSA-N |
| PubChem CID | 8607 |
| ChEMBL | CHEMBL1883819 |
| ChEBI | CHEBI:82019 |
| EC No. | 205-088-6 |
| DTXSID | DTXSID0021385 |
Chemical & Physical Properties
| XLogP | 2.8 |
|---|---|
| Topological polar surface area | 62.7 |
| Hydrogen bond donors | 0 |
| Hydrogen bond acceptors | 3 |
| Rotatable bonds | 1 |
| Heavy atoms | 16 |
| Formal charge | 0 |
| Complexity | 307 |
| Chemical classes | Carcinogens |
| SpringerMaterials Properties | Fusion temperature |
| Pesticides | Pesticide -> EPA IRISAgrochemicals -> Pesticide active substancesActive substance -> EU Pesticides database: ApprovedPesticides -> FungicidesEnvironmental transformation -> Pesticides (parent, predecessor) |
| LogP (partition coefficient) | log Kow = 2.853.11 |
| Density | 1.72 at 20 °C1.5097 (rough estimate) |
| Color/Form | Crystals from benzeneLight colored powderColorless crystalsWhite crystals |
| Solubility | In carbon tetrachloride 6, toluene 26, methanol 3 (all in g/L at 25 °C)Slightly soluble in organic solvents.87 g/L chloroform22 g/L benzene12.5 g/L isopropanolIn water, 0.8 mg/L at room temperature0.0008 mg/mL at 25 °CSolubility in water: noneChloroform (Slightly), Methanol (Slightly)practically insoluble |
| Corrosivity | NON-CORROSIVEDECOMP PRODUCTS ARE CORROSIVE |
| Endocrine Disruptors | Potential endocrine disrupting compound |
| Decomposition | When heated to decomp it emits very toxic fumes of /hydrogen chloride, nitrogen oxides & sulfur oxides/. |
| Melting point | 177 °C177-180°C |
| Vapor pressure | 0.00000016 [mmHg]2.1X10-2 mPa /1.57X10-7 mm Hg/ at 25 °CVapor pressure, Pa at 20 °C:2.1 x 10-5 Pa (25 °C) |
| Boiling point | 333.8±52.0 °C(Predicted) |
| Refractive index | 1.6000 (estimate) |
| Storage conditions | 0-6°C |
| pKa (acidity coefficient) | -3.34±0.20(Predicted) |
| Physical state | Solid |
| Color | Crystals |
| Merck | 13,4250 |
| BRN | 193373 |
| Henry's law constant | 1.3×102 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| Major applications | agriculturecleaning productscosmeticsenvironmentalfood and beveragespersonal care |
| InChI | 1S/C9H4Cl3NO2S/c10-9(11,12)16-13-7(14)5-3-1-2-4-6(5)8(13)15/h1-4H |
| InChIKey | HKIOYBQGHSTUDB-UHFFFAOYSA-N |
| SMILES | ClC(Cl)(Cl)SN1C(=O)c2ccccc2C1=O |
| LogP (partition coefficient) | 2.850 |
| CAS DataBase Reference | 133-07-3(CAS DataBase Reference) |
| EWG's Food Scores | 6 |
| FDA UNII | X5NFK36917 |
| Proposition 65 List | Folpet |
| NIST Chemistry Reference | Folpet(133-07-3) |
| EPA Substance Registry System | Folpet (133-07-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
| GHS pictogram | GHS07,GHS08,GHS09 |
| Signal word | Warning |
| GHS hazard statements | H317-H319-H332-H351-H400 |
| GHS precautionary statements | P273-P280-P302+P352-P304+P340+P312-P305+P351+P338-P308+P313 |
| Personal protective equipment (PPE) | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges |
| Hazard symbols | Xn,N |
| Risk statements (R) | 20-36-40-43-50 |
| Safety statements (S) | 36/37-46-61 |
| UN transport number | UN 3077 9/PG 3 |
| Water hazard class (WGK) | 2 |
| RTECS number | TI5685000 |
| TSCA inventory status | TSCA listed |
| Hazard class | 9Acute Tox. 4 InhalationAquatic Acute 1Carc. 2Eye Irrit. 2Skin Sens. 1 |
| Packing group | III |
| Customs code | 29309090 |
| Storage class | 11 - Combustible Solids |
| Hazardous substances data | 133-07-3(Hazardous Substances Data) |
| Toxicity | LD50 orally in adult male, female rats: >5000 mg/kg (Gaines, Linder) |
Safety & Regulations
| GHS classification | WarningH317: May cause an allergic skin reaction [Warning Sensitization, Skin]P203, P261, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P317, P318, P321, P333+P317, P337+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement)H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin] |
|---|---|
| Regulatory information | Chemical: 1H-Isoindole-1,3(2H)-dione, 2-[(trichloromethyl)thio]-Hazard Traits - CarcinogenicityRegulation (EC) No 396/2005 (amended)Folpet is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)07/5/EC, Reg. (EU) 2020/869, Reg. (EU) 2021/745, Reg. (EU) 2022/708, Reg. (EU) 2023/918, Reg. (EU) 2024/2198, Reg. (EU) No 2019/707, Reg.(EU) No 2018/917, Reg.(EU) No 540/2011Folpet: HSNO Approval: HSR002854 Approved with controls |
| DOT label | Class 9 |
| Fire hazards | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Combustible under specific conditions. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. |
| Health hazards | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: |
| Hazards summary | A skin sensitizer in guinea pigsSensitization not reported in humans despite wide-scale useTLV Basis is liver damage and body weight effects[ACGIH] The thiophthalimides include captan, captafol, and folpet. No systemic poisonings in humans have been reported. [EPA Pesticides] An eye irritantMay cause skin sensitizationCan be absorbed through skin[ICSC] Rapidly forms the short-lived and highly reactive metabolite thiophosgene in the presence of thiols in tissue and blood[Reference #2] Birth defects observed at very high doses in one study of hamsters, although negative results seen in studies of mice, rats, rabbits, and monkeys[REPROTOX] A severe eye irritant and skin sensitizerNo evidence of toxicity to fertility or reproduction in a 2-generation study of rats, but teratogenic effects observed in rabbitsNot genotoxic in vivo but carcinogenic in mice[EFSA] |
| Reactive group | Amides and Imides |
| EC classification | Symbol: Xn, NR: 20-36-40-43-50S: (2)-36/37-46-61 |
| UN classification | UN Hazard Class: 9UN Pack Group: III |
| Special Reports | USEPA/Office of Pesticide ProgramsReregistration Eligibility Decision Document - Folpet, EPA 738-R-99-011 (November 1999). The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of January 26, 2012: http://www.epa.gov/pesticides/reregistration/status.htm]Toxicology Review: Mutation Research 32 (1): 3 (1975) |
| FIFRA requirements | Tolerances are established for the fungicide folpet (N-(trichloromethylthio)phthalimide) in or on raw agricultural commodities as follows: [Table#4123]Tolerances with regional registrations as defined in part 180.1(l) are established for the fungicide folpet ( N -(trichloromethylthio)phthalimide) in or on the following raw agricultural commodity: Avocado.Based on the reviews of the generic data for the active ingredient folpet, the Agency has sufficient information on the health effects of folpet and on its potential for causing adverse effects in fish, wildlife, and the environment. The Agency has determined that folpet products, labeled and used as specified in this Reregistration Eligibility Decision Document, will not pose unreasonable risks of adverse effects to humans or the environment. Therefore, the Agency concludes that products containing folpet for use on Florida avocados and for use in sealants and coatings (such as caulking, paints, and stains) are eligible for reregistration.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Folpet is found on List A, which contains most pesticides that are used on foods and, hence, have a high potential for human exposure. List A consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA '88. Case No: 0630Pesticide type: fungicideRegistration Standard Date: 06/30/87Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.Active ingredient (AI): folpetData Call-in (DCI) Date(s): 01/11/93, 10/13/95AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner. |
| Reactivity Profile | A halogenated phthalimide. |
| Chemical Dangers | Decomposes on heating. This produces toxic and corrosive fumes including sulfur oxides, nitrogen oxides and hydrogen chloride (see ICSC 0163). |
| Fire fighting | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Use water spray, powder, foam, carbon dioxide. |
| First aid measures | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap. Seek medical attention if you feel unwell.Rinse with plenty of water for several minutes (remove contact lenses if easily possible).Rinse mouth. Seek medical attention if you feel unwell. |
| First aid | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: |
| Safe storage | Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access. Separated from food and feedstuffs. |
| Fire fighting procedures | Extinguishing Media: In case of small fire: foam or dry chemical, carbon dioxide. In case of large fire: water spray, fog or regular foam. /Folpan 80 WDG Fungicide/Firefighters should wear suitable protective clothing. Self-contained breathing apparatus. Fight fires from a protected location. Dike fire control water for later disposal. /Folpan 80 WDG Fungicide/ |
| Storage conditions | Store in dry place at ambient or lower temperatures.Store in a cool, dry ventilated place. Protect from excessive heat. Keep locked up. Keep containers tightly closed. Keep only in the original container in ... Keep containers dry. To prevent contamination, store this product away from food or feed. Keep away from heat, fire and sparks.. /Folpan 80 WDG Fungicide/Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water. /Residential users/PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/ |
| Cleanup methods | Do not contaminate water by cleaning of equipment or disposal of rinsate. /Folpan 80 WDG Fungicide/If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label./Residential users/After Applying a Pesticide, Indoors or Outdoors. To remove pesticide residues, use a bucket to rinse tools or equipment three times, including any containers or utensils that you used when mixing the pesticide. Then pour the rinsewater into the pesticide sprayer and reuse the solution by applying it according to the pesticide product label directions. After applying any pesticide wash your hands and any other parts of your body that may have come in contact with the pesticide..To prevent tracking pesticides inside, remove or rinse your boots or shoes before entering your home. Wash any clothes that have been exposed to a lot of pesticide separately from your regular wash. /Residential users/PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/ |
| Nonfire spill response | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: |
| Disposal methods | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal and plant lifeand conformance with environmental and public health regulations.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.Recommendable method: Incineration. Peer-review: For large amt, incineration in a unit with effluent gas scrubbing is recommendable. (Peer-review conclusions of an IRPTC expert consultation (May 1985))Safe Disposal of Pesticides. The best way to dispose of small amounts of excess pesticides is to use them - apply them - according to the directions on the label. If you cannot use them, ask your neighbors whether they have a similar pest control problem and can use them. If all of the remaining pesticide cannot be properly used, check with your local solid waste management authority, environmental agency, or health department to find out whether your community has a household hazardous waste collection program or a similar program for getting rid of unwanted, leftover pesticides. These authorities can also inform you of any local requirements for pesticide waste disposal. /Residential users/For more Disposal Methods (Complete) data for FOLPET (10 total), please visit the HSDB record page. |
| Spillage disposal | Personal protection: protective gloves and chemical protection suit. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. |
| Preventive Measures | SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR part 170. /Folpan 80 WDG Fungicide/Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 24 hours. /Folpan 80 WDG Fungicide//Restricted-entry interval (REI) of 24 hours./ PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated such as plants, soil, or water, is: Protective eyewear such as safety glasses, goggles, or face shieldCoveralls over short-sleeved shirt and short pantsChemical-resistant glovesand Chemical-resistant footwear plus socks. /Folpan 80 WDG Fungicide/For more Preventive Measures (Complete) data for FOLPET (22 total), please visit the HSDB record page. |
| Isolation and Evacuation | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: |
| Body burden | Of nine domiciles located in Jacksonville, FL monitored for folpet in respiratory air during August, 1985, folpet was qualitatively identified in 4 domiciles(1). Personal exposure air samples taken on two separate days from a household located in an area of high pesticide use contained folpet concentrations of 0.19 and 0.023 ug/cu m, respectively(1). Of 248 households located in Jacksonville, FL monitored for personal air in the summer of 1986, the spring of 1987, and the winter of 1988, folpet was quantitatively identified in 2% (0.4 ng/cu m weighted mean concentration), 2% (0.4 ng/cu m weighted mean concentration), and 2% (0.8 ng/cu m weighted mean concentration) of all households sampled, respectively(2). Of 128 households located in Springfield/Chicopee, MA monitored for personal air in the spring of 1987 and the winter of 1988, folpet was quantitatively identified in 2% (0.7 ng/cu m weighted mean concentration) and less than 1% of all households sampled, respectively(2). |
| Cancer Sites | Gastrointestinal |
| Target organs | Hepatic |
| Ecotoxicity values | LC50Species: Anas platyrhynchos (Mallard Duck) juvenilediet >5000 ppm for 8 daysLD50Species: Anas platyrhynchos (Mallard duck) male, 3-4 month oldoral >2000 mg/kg /purity 92.4%/Species: Colinus virginianus (Bobwhite quail) juvenileSpecies: Colinus virginianus (Bobwhite quail) age >16 wkoral via capsule >2510 mg/kgFor more Ecotoxicity Values (Complete) data for FOLPET (56 total), please visit the HSDB record page. |
| Environmental fate | TERRESTRIAL FATE: Based on a classification scheme(1), a Koc range of 7.47 to 21.9(2), indicates that folpet is expected to have very high mobility in soil(SRC). Volatilization of folpet from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 7.7X10-8 atm-cu m/mole(SRC), based upon its vapor pressure, 1.57X10-7 mm Hg(3), and water solubility, 0.8 mg/L(3). Folpet is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Soil metabolism studies report degradation half-lives of 2.4-2.5 days under aerobic conditions and <7-15 days under anaerobic conditions(2), suggesting that biodegradation is an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), a Koc range of 7.47 to 21.9(2), indicates that folpet is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 7.7X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 1.57X10-7 mm Hg(4), and water solubility, 0.8 mg/L(4). According to a classification scheme(5), a BCF of range of 19 to 81(2), suggests the potential for bioconcentration in aquatic organisms is low to moderate(SRC). Biodegradation data in water were not available(SRC, 2012).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), folpet, which has a vapor pressure of 1.57X10-7 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase folpet is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 8 hours(SRC), calculated from its rate constant of 1.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase folpet may be removed from the air by wet or dry deposition(SRC). The UV spectrum of folpet in hexane shows no absorbance at wavelengths above 300 nm(4), and therefore folpet is not expected to be susceptible to direct photolysis by sunlight(SRC). |
| Food survey values | 6,391 domestic agricultural commodities were tested by surveillance sampling at the U.S. Food and Drugs Administration's Los Angeles District Laboratory from 10/1/81 to 9/30/86. Folpet residues were found in 24, 15, 57, 46, 31, and 28 of 6,391 commodities tested in concentration ranges of 0.05, 0.1, 0.5, 1.0, 2.0, and greater than 2.0 ppm, respectively. 12,044 imported agricultural commodities tested by surveillance sampling at the U.S. Food and Drugs Administration's Los Angeles District Laboratory from 10/1/81 to 9/30/86. Folpet residues were 1, 1, 2, 1, and 13 of the 12,044 commodites tested in concentration ranges of 0.05, 0.1, 0.5, 2.0, and greater than 2.0 ppm, respectively. 177 domestic agricultural commodities were tested by compliance sampling at the U.S. Food and Drug Administration's Los Angeles District Laboratory from 10/1/81 to 9/30/86. Folpet residues were found in 5 and 1 findings in concentration ranges of 0.05 and 0.5 ppm, respectively. 1,239 imported agricultural commodities were tested by compliance sampling at the U.S. Food and Drug Administration's Los Angeles District Laboratory from 10/1/81 to 9/30/86. Folpet residues were found in 1, 1, and 1 of 1,239 commodities tested in concentration ranges of 0.5, 1.0 and 2.0 ppm, respectively(1).Pesticide residue findings for food products tested by 10 state food laboratories for the U.S. Food and Drug Administration during fiscal year 1988 were 108 findings out of 13,980 samples(1). Pesticide residue findings for food products tested by 10 state food laboratories for the U.S. Food and Drug Administration during fiscal year 1989 were 27 findings out of 13,085 samples(1). Folpet was qualitatively found as residue in samples tested during the Food and Drug Administration pesticide residue monitoring of various food samples during the test period of 1978-1982(2), during the test period of 1983-1986(3), during the test period of 1988-1989(4), and during the test period of 1989-1990(5).In 1992-1993, domestic and imported pears and tomatoes were tested by the Food and Drug Administration in a statistically based study of pesticide residues. Folpet was not detected in samples of 710 domestic pears, 949 imported pears, and 1219 domestic tomatoes. Folpet was detected in 3 out of 144 samples of imported tomatoes, with a maximum level found of 0.11 ppm(1). In a compilation of monitoring data compiled through the US Food and Drug Administration's Market Basket Studies for the years 1982-1991, folpet was detected in 3 of 234 ready-to-eat food items that were tested. The average levels detected were 10.5 ng/g, 14.0 ng/g, and 225 ng/g in fresh grapes, plums, and strawberries, respectively(2). 109 of 2338 samples of Ontario, Canada-produced fruits and vegetables, collected between 1991 to 1995 contained folpet, at concentrations from <0.01 to >10 ug/g, a 4.7% detection frequency4 of the 109 samples where this compound was detected had concentrations of folpet which were sufficient to violate maximum residue limits set by Health Canada(3). Sampling from January 1994 through December 2001 of Sao Paulo, Brazil-produced fruits (1523) and vegetables (700) revealed folpet concentrations from 0.02 to 7.53 mg/kg (mean 0.82 mg/kg)2 of the 77 samples where this compound was detected had concentrations of folpet which were sufficient to violate maximum residue limits(4). |
| Adverse effects | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
| Exposure routes | The substance can be absorbed into the body by inhalation. |
| Average Daily Intake | Using monitoring data from the FDA's Market Basket Survey during the period of 1988-89, the AVDI in 6-11 month old infants, 14-16 year old males and 60-65 year old females was 0.4, 0.2, and 0.5 ng/kg-body weight/day, respectively(1). Using monitoring data from the FDA's Market Basket Survey during the period of 1989-90, the AVDI in 6-11 month old infants, 14-16 year old males and 60-65 year old females was 0.1, 0.1, and less than 0.1 ng/kg-body weight/day, respectively(2). Using monitoring data from the FDA's Market Basket Survey during the period of 1986-91, the AVDI in 6-11 month old infants, 14-16 year old males and 60-65 year old females was 1.8, 0.7, and 2.0 ng/kg-body weight/day, respectively(3). |
| Ecotoxicity excerpts | /BIRDS and MAMMALS/ Acute oral toxicity in male mallards/: only signs seen were mild ataxia and wings crossed high over back for up to 18 days. Slight weight losses occurred./PLANTS/ Non-phytotoxic, except to sweet cherries and the D'Anjou variety of pears. Russetting is possible in sensitive apple varieties if applied early in cropping. |
| Plant Concentrations | In Dade County, FL, five foliar applications of folpet (50WP) at 3 lb ai/acre/application were applied to avocados. Following the final application, triplicate samples of avocados were collected at 1, 3, 7, 14, and 28 days post treatment. Folpet residues at day 1 were 0.101-0.183 ppm and declined to <0.05-0.066 ppm by day 28. The maximum folpet residue (0.356 ppm) was found in the day 3 sample(1). |
| Signs and Symptoms | Dry skin.Redness. |
| State drinking water guidelines | (ME) MAINE 100 ug/l |
| Personal protective equipment (PPE) | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges |
| Water hazard class (WGK) | 2 |
| TSCA inventory status | TSCA listed |
| RTECS number | TI5685000 |
| UN transport number | UN 3077 9/PG 3 |
| Customs code | 29309090 |
| Toxicity | LD50 orally in adult male, female rats: >5000 mg/kg (Gaines, Linder) |
| Risk statements (R) | 20-36-40-43-50 |
| Signal word | Warning |
| GHS pictogram | GHS07,GHS08,GHS09 |
| Hazard symbols | Xn,N |
| Safety statements (S) | 36/37-46-61 |
| Hazard class | 9Acute Tox. 4 InhalationAquatic Acute 1Carc. 2Eye Irrit. 2Skin Sens. 1 |
| Storage class | 11 - Combustible Solids |
| Packing group | III |
| GHS hazard statements | H317-H319-H332-H351-H400 |
| GHS precautionary statements | P273-P280-P302+P352-P304+P340+P312-P305+P351+P338-P308+P313 |
| Hazardous substances data | 133-07-3(Hazardous Substances Data) |
Applications & Uses
Description
Folpet is practically insoluble in water. It is a protective leaf fungicide. Its mode of action inhibits normal cell division of a broad spectrum of microorganisms. It is used to control cherry leaf spot, rose mildew, rose black spot, and apple scab. It is used on berries, flowers, ornamentals, fruits, and vegetables and for seedand plant-bed treatment. It is also used as a fungicide in paints and plastics and for treatment of internal and external structural surfaces of buildings. It is incompatible with strongly alkaline preparations, such as lime sulphur.
Uses
Folpet is used to control downy mildews, powdery mildews, leaf spot diseases, scab and rots in fruit, ornamentals and vegetables.
Uses
Folpet is a pesticide, fungicide agent from the thiophtalimide group. Occupational exposure occurs mostly in agricultural workers or in florists.
Uses
Agricultural fungicide.
General Description
White crystals. Used as a fungicide. Insoluble in water.