Ammonia → HCID 13876411, compound

HRID 1089132

Reaction equation

HRID 1089132 reaction equation
[CH3:1][O:2][C:3]1[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][C:4]=1[O:5][CH2:6][C:7]([OH:9])=[O:8].N>[Ni].CO>[CH3:1][O:2][C:3]1[CH:13]=[C:12]([CH2:14][NH2:15])[CH:11]=[CH:10][C:4]=1[O:5][CH2:6][C:7]([OH:9])=[O:8]

Participants

5

Reactant 2

HCID 222AmmoniaHCID 12209582-(4-Cyano-2-methoxyphenoxy)acetic acid

Product 1

HCID 13876411HCID 13876411, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

3.3 g of 2-(2-methoxy-4-cyanophenoxy)-acetic acid are hydrogenated in 90 ml of a 2:1 (by volume) mixture of methanol and 25% aqueous ammonia in the presence of 1.6 g of Raney nickel for 5 hours at room temperature under normal pressure. After filtering off the catalyst, it is washed with methanol and water and the filtrate is then concentrated to dryness. The resulting solid material is triturated with a small amount of water, filtered off and dried over P2O5 in an exsiccator.

Workup

  1. filtrationAfter filtering off the catalyst, it
  2. washis washed with methanol and water
  3. concentrationthe filtrate is then concentrated to dryness
  4. customThe resulting solid material is triturated with a small amount of water
  5. filtrationfiltered off
  6. dry with materialdried over P2O5 in an exsiccator

Sources & evidence

ORD record
ord-5c964da8f7d04622a287b1ab22922095
Source dataset
uspto-grants-1990_10
Patent number
US04965260

Linked notes

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