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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 11913Generated: October 24, 2026

Sodium cyanoborohydride → (4R,9aR)-6-bromo-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester

https://huagongshe.com/en/reaction/11913

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium cyanoborohydrideHCID 5003444—
Reactant(R)-6-chloro-4-methyl-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-oneHCID 86590110—
Reactant(4R)-6-bromo-4-methyl-3,4-dihydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl esterHCID 86590112—
Product(4R,9aR)-6-bromo-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl esterHCID 86590113—

Reaction Steps

This compound was prepared in analogy to Example 2, intermediate b) from (R)-6-bromo-4-methyl-3,4-dihydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester and sodium cyano borohydride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07098337B2
Source datasetuspto-grants-2006_08
ORD IDord-1a8b29b5053c40f587e0586b30fa4d8a
Source noteuspto-grants-2006_08