HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 2-(Tert-butyldiphenylsilyloxymethyl)imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| Reactant | 1H-Imidazole-2-methanol | HCID 566830 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(Tert-butyldiphenylsilyloxymethyl)imidazole | HCID 53676658 | 82% |
Reaction Steps
A solution of 2-hydroxymethylimidazole (1.96 g ; 0.02 mole), imidazole (3.4 g; 0.05 mole), tert-butyldiphenylsilyl chloride (6.6 g; 0.024 mole) in DMF (20 ml) was stirred under an argon atmosphere for 16 hours. The mixture was extracted with ethyl acetate and purified by flash column chromatography eluting with a gradient 50-70% ethyl acetate/petroleum ether to give 2-(tert-butyldiphenylsilyloxymethyl)imidazole as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06342765B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-629180fcd2854c04ab9ada2162252392 |
| Source note | uspto-grants-2002_01 |