HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → Methyl-5-pyrrolidin-1-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide | HCID 25013543 | — |
| Product | Methyl-5-pyrrolidin-1-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide | HCID 25013861 | — |
Reaction Steps
Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 88 mg; 0.30 mmol) and pyrrolidine (0.25 mL; 3.0 mmol) under microwave irradiation according to the procedure described for Example 14 provided after purification by reverse phase HPLC, 1-methyl-5-pyrrolidin-1-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (60 mg, 61%) as an off-white powder. ES-HRMS m/e calcd for C19H29N4O (M+H+) 329.2336, found 329.2334.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728029B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-d97e5bf6b4d74c92bb92f5736a353ea1 |
| Source note | uspto-grants-2010_06 |