Sodium Acetate → HCID 2910222, compound

HRID 1289158

Reaction equation

HRID 1289158 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][O:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=1.C([O-])(=O)C.[Na+].[S:24]1[CH2:30][C:28](=[O:29])[NH:27][C:25]1=[S:26]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][O:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[C:30]2[S:24][C:25](=[S:26])[NH:27][C:28]2=[O:29])=[CH:13][CH:12]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 7354674-[(2-Chloro-6-fluorophenyl)methoxy]benzaldehydeHCID 1201546Rhodanine

Product 1

HCID 2910222HCID 2910222, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Under a nitrogen atmosphere in a round bottom flask 4-[(2-chloro-6-fluorophenyl)methoxy]benzaldehyde (1.00 g, 3.78 mmol) was dissolved in acetic acid (19 ml). To this solution was added sodium acetate (1.08 g, 13.2 mmol) and then rhodanine (0.50 g, 3.75 mmol). The reaction mixture was then heated to reflux and maintained at this temeprature. The progress of the reaction was monitored by thin layer chromatography.

Workup

  1. temperatureThe reaction mixture was then heated
  2. temperatureto reflux
  3. temperaturemaintained at this temeprature

Sources & evidence

ORD record
ord-093ea1f308e842fbb0137430c1943964
Source dataset
uspto-grants-1998_05
Patent number
US05747517

Linked notes

Loading…