HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-(Trifluoromethoxy)phenyl isocyanate → 1-(6-Bromo-2-(2-(2-ethoxypropan-2-yl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-(Trifluoromethoxy)phenyl isocyanate | HCID 92298 | — |
| Reactant | 6-Bromo-2-(2-(2-ethoxypropan-2-yl)phenoxy)pyridin-3-amine | HCID 86601896 | — |
| Product | 1-(6-Bromo-2-(2-(2-ethoxypropan-2-yl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea | HCID 86601895 | — |
Reaction Steps
Example 582 was prepared from 6-bromo-2-(2-(2-ethoxypropan-2-yl)phenoxy)pyridin-3-amine and p-trifluoromethoxyphenyl isocyanate according to the procedure described for Example 2. (M−EtO)=508, 510. 1H NMR (400 MHz, DMSO-d6) δppm 0.82 (t, J=7.0 Hz, 3H), 1.53 (s, 6H), 3.21 (q, J=7.0 Hz, 2H), 7.21 (dd, J=8.1, 1.3 Hz, 1H), 7.30 (m, 6H), 7.56 (m, 4H), 8.49 (d, J=8.4 Hz, 1H), 8.73 (s, 1H), 9.61 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07388021B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-8f7f31758e064d5584f15af0eca82a91 |
| Source note | uspto-grants-2008_06 |