1H-Pyrazole-3-carbaldehyde → 5-(2-Cyanopyridin-3-yloxy)-2-(1H-pyrazol-3-yl)-6-(6-methanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

HRID 13305

Reaction equation

HRID 13305 reaction equation
[C:1]([C:3]1[C:8]([O:9][C:10]2[C:24]([O:25][C:26]3[CH:27]=[N:28][C:29]([S:32]([CH3:35])(=[O:34])=[O:33])=[CH:30][CH:31]=3)=[CH:23][C:13]3[NH:14][C:15]([C:17]4[CH:22]=[CH:21]C=C[N:18]=4)=[N:16][C:12]=3[CH:11]=2)=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:2].[NH:36]1C=CC(C=O)=N1>>[C:1]([C:3]1[C:8]([O:9][C:10]2[C:24]([O:25][C:26]3[CH:27]=[N:28][C:29]([S:32]([CH3:35])(=[O:33])=[O:34])=[CH:30][CH:31]=3)=[CH:23][C:13]3[NH:14][C:15]([C:17]4[CH:22]=[CH:21][NH:36][N:18]=4)=[N:16][C:12]=3[CH:11]=2)=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 122183831H-Pyrazole-3-carbaldehydeHCID 231456955-(2-cyanopyridin-3-yloxy)-6-(6-methanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole

Product 1

HCID 1785048075-(2-Cyanopyridin-3-yloxy)-2-(1H-pyrazol-3-yl)-6-(6-methanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

Procedure

The entitled compound was obtained as a colorless solid in the same method as in Example 202 or in accordance with the method or by combining it with an ordinary method but using 4-(2-cyanopyridin-3-yloxy)-5-(6-methanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 218 (step 3) and 1H-pyrazole-3-carboxaldehyde.

Workup

  1. customThe entitled compound was obtained as a colorless solid in the same method as in Example 202 or in accordance with the method

Sources & evidence

ORD record
ord-e2d9d0f81bdd4219a823d248be209895
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Linked notes

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