HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1354607Generated: October 23, 2026
1,4-Dioxane hydrochloride → 2-(4-Chloro-2-oxo-1,2-dihydro-pyridin-3-yl)-7-methyl-3H-benzimidazole-5-carbonitrile
https://huagongshe.com/en/reaction/1354607
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | 2-(4-Iodo-2-methoxy-pyridin-3-yl)-7-methyl-3H-benzimidazole-5-carbonitrile | HCID 22021013 | — |
| Product | 2-(4-Chloro-2-oxo-1,2-dihydro-pyridin-3-yl)-7-methyl-3H-benzimidazole-5-carbonitrile | HCID 135681642 | — |
Reaction Steps
A suspension of 2-(4-iodo-2-methoxy-pyridin-3-yl)-7-methyl-3H-benzimidazole-5-carbonitrile (1.8 g, 4.63 mmol) in 4 M HCl dioxane (40 mL) was heated to 80° C. for 6 h and cooled to room temperature. The precipitate was filtered and dried. The crude product (1.08 g, 82%) was used for the next step without purification. LRMS (neg. ESI, (M−H)−) m/z 283.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07223757B2 |
|---|
| Source dataset | uspto-grants-2007_05 |
|---|
| ORD ID | ord-1e4f7bb0be984132832467b73edb6a6c |
|---|
| Source note | uspto-grants-2007_05 |
|---|
