HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Bromomethyl)-3-phenoxybenzene → m-Phenoxybenzyl 2-isopropyl-4-(o-chlorophenyl)-3-butenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Bromomethyl)-3-phenoxybenzene | HCID 94544 | — |
| Reactant | 2-(2-Chlorophenyl)acetaldehyde | HCID 11378624 | — |
| Reactant | HCID 53812558 | HCID 53812558 | — |
| Reactant | 2-Isopropyl-4-(o-chlorophenyl)-3-butenoic acid | HCID 54528296 | — |
| Reactant | KOH MeOH Water | HCID 86591755 | — |
| Product | m-Phenoxybenzyl 2-isopropyl-4-(o-chlorophenyl)-3-butenoate | HCID 54240396 | — |
Reaction Steps
The process of Example 3 is repeated using o-chlorophenylacetaldehyde to prepare ethyl 2-isopropyl-4-(o-chlorophenyl)-3-butenoate, which is hydrolyzed (potassium hydroxide-water/methanol) to the acid, 2-isopropyl-4-(o-chlorophenyl)-3-butenoic acid. The acid is reacted with m-phenoxybenzyl bromide as in Example 1 to yield m-phenoxybenzyl 2-isopropyl-4-(o-chlorophenyl)-3-butenoate. MS m/e 420 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04204071 |
| Source dataset | uspto-grants-1980_05 |
| ORD ID | ord-cea0b473752c47b5ad7e966fcd44a7ba |
| Source note | uspto-grants-1980_05 |