Ethanolamine → HCID 21408176, compound

HRID 1414860

Reaction equation

HRID 1414860 reaction equation
[C:1]([C:4]1[CH:9]=[N+:8]([O-:10])[C:7]([CH3:11])=[CH:6][N:5]=1)([OH:3])=[O:2].C(CN)O>CO>[CH2:1]([CH2:4][NH2:5])[OH:2].[C:1]([C:4]1[CH:9]=[N+:8]([O-:10])[C:7]([CH3:11])=[CH:6][N:5]=1)([OH:3])=[O:2]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 5310993Acipimox

Product 1

HCID 21408176HCID 21408176, compoundYield 120.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Carboxy-5-methylpyrazine 4-oxide (2.5 g) was added to methanol (60 ml) and ethanolamine (1.1 ml). The mixture was refluxed for 20 minutes, then cooled and filtered to obtain 2-carboxy-5-methylpyrazine 4-oxide ethanolamine salt (2.1 g), m.p. 177°-180° C, after crystallisation from methanol.

Workup

  1. temperatureThe mixture was refluxed for 20 minutes
  2. temperaturecooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-69e379b6fcd04fc388045f6b6382e596
Source dataset
uspto-grants-1977_01
Patent number
US04002750

Linked notes

Loading…