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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1468017Generated: October 23, 2026

5-(Methylsulfonyl)-1H-indole → tert-Butyl-4-(((6-(5-(methylsulfonyl)-1H-indol-1-yl)pyridin-3-yl)oxy)methyl)piperidine-1-carboxylate

https://huagongshe.com/en/reaction/1468017

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Methylsulfonyl)-1H-indoleHCID 14973230—
Reactanttert-Butyl 4-{[(6-chloropyridin-3-yl)oxy]methyl}piperidine-1-carboxylateHCID 59718534—
Producttert-Butyl-4-(((6-(5-(methylsulfonyl)-1H-indol-1-yl)pyridin-3-yl)oxy)methyl)piperidine-1-carboxylateHCID 67617401—

Reaction Steps

The title compound was prepared by following the similar procedure as described in Example-1 using 5-(methylsulfonyl)-1H-indole (intermediate-21) and tert-butyl 4-(((6-chloropyridin-3-yl)oxy)methyl)piperidine-1-carboxylate (intermediate-29) (0.188 g, 11%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09000175B2
Source datasetuspto-grants-2015_04
ORD IDord-14232dbf8edb4af28c192f544b7582a2
Source noteuspto-grants-2015_04