3-Methoxytyramine → 4-{2-[4-(3-Butoxy-phenyl)-pyrimidin-2-ylamino]-ethyl}-2-methoxy-phenol

Participants

Reaction Steps

Intermediate 46 was coupled with 4-(2-Amino-ethyl)-2-methoxy-phenol following procedure F. LC-MS showed the product had the expected M+H+ of 394. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) δ 8.3 (m, 1H) 7.6 (m, 2H) 7.35 (m, 1H) 7.0 (m, 2H) 6.85 (m, 1H) 672 (m, 2H) 5.51 (br s, 1H) 4.0 (t, 2H) 3.75 (s, 3H) 3.7 (m, 2H) 2.89 (t, 2H) 1.78 (d, 2H) 1.5 (d, 2H) (t, 3H).

Provenance & Evidence