HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodide Ion → 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(1-methyl-1H-pyrazol-3-yl)propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodide Ion | HCID 30165 | — |
| Reactant | 1-Methyl-3-aminopyrazole | HCID 137254 | — |
| Reactant | Ethyl-4,4-difluorocyclohexane carboxylate | HCID 2779138 | — |
| Reactant | tert-butyl 2-ethoxycarbonylmethyl-5,5-dioxo-5H-phenothiazine-10-carboxylate | HCID 59340981 | — |
| Reactant | 1,1-Difluoro-4-(iodomethyl)cyclohexane | HCID 67236985 | — |
| Product | 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(1-methyl-1H-pyrazol-3-yl)propionamide | HCID 58024230 | — |
Reaction Steps
Analogously to Example 36 and Example 44, tert-butyl 2-ethoxycarbonylmethyl-5,5-dioxo-5H-phenothiazine-10-carboxylate, 1,1-difluoro-4-iodomethylcyclohexane (prepared from commercially available ethyl 4,4-difluorocyclohexanecarboxylate analogously to the synthesis of the iodide described in Example 40) and 1-methyl-1H-pyrazol-3-amine give 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(1-methyl-1H-pyrazol-3-yl)propionamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732440B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-9bb50b18badf4dd7903ca55bbb1fedd2 |
| Source note | uspto-grants-2010_06 |