HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Cyanide → 4-Hydroxy-3-methoxyphenylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Cyanide | HCID 768 | — |
| Reactant | Vanillyl alcohol | HCID 62348 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-Hydroxy-3-methoxyphenylacetonitrile | HCID 78220 | — |
Reaction Steps
185g of 3-methoxy-4-hydroxybenzyl alcohol are dissolved in 1,250 ml of DMSO and 35g of anhydrous hydrocyanic acid are passed in over the course of 1 hour at 125°C. The mixture is then stirred for a further 2 hours, and worked up as indicated above. The yield was 160.5g (82% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03983160 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-70f38d4a54f142658a425b4605e80135 |
| Source note | uspto-grants-1976_09 |