Bromine → HCID 19765761, compound

Participants

Reaction Steps

0,2 mM of Pd(Ph3P)2Cl2 and 0,1 mM of CuJ are added to a mixture of 0,01 M of 3-bromo-2,6-difluoropyridine (preparation: 2,6-difluoropyridine is reacted with lithiumdiisopropylamide (LDA) as described in example 3a, then Br2 is added at -60° to -70°. The mixture is allowed to warm up to room temperature and worked up, the product is purified by distillation), 0,01 M of 4-pentylphenylacetylene and 200 ml of triethylamine. The mixture is stirred for 8 hours at room temperature; after customary work-up and purification by crystallization and chromatography 1-(4-pentylphenyl)-2-(2,6-difluoropyridine-3-yl)acetylene is obtained.

Provenance & Evidence