HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → 3-Furancarboxylic acid, 2,5-dimethyl-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | 2-(Acetyloxy)propanal | HCID 90728 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Furancarboxylic acid, 2,5-dimethyl-, methyl ester | HCID 80248 | — |
Reaction Steps
40 parts by weight of iron-III chloride and 136 parts by weight of 85 percent strength α-acetoxypropionaldehyde are added successively to a solution of 150 parts by weight of methyl acetoacetate in 120 parts by weight of methanol. The mixture, which becomes warm, is then refluxed for 2 hours. When it has cooled, the reaction solution is washed with water and distilled. 127 g of 2,5-dimethylfuran-3-carboxylic acid methyl ester are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04207243 |
| Source dataset | uspto-grants-1980_06 |
| ORD ID | ord-a86d7762caed427391b66ee59855b844 |
| Source note | uspto-grants-1980_06 |