HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 5-Bromo-2-methyl-4-(4-nitrophenyl)-1,3-thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 2-Methyl-4-(4-nitrophenyl)thiazole | HCID 193689 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 5-Bromo-2-methyl-4-(4-nitrophenyl)-1,3-thiazole | HCID 68998100 | 60% |
Reaction Steps
Bromine (6 mmol) was added dropwise to a solution of 2-methyl-4-(4-nitrophenyl)-1,3-thiazole (5 mmol) in chloroform (20 mL) and the solution refluxed for 4 h. The solvent was evaporated and the product purified by crystallization from ether to afford the title compound (60%). ESMS [M+H]+: 300.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07495102B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-d0c34458662e4028bdddffb6d44372ca |
| Source note | uspto-grants-2009_02 |