Reaction equation
[I:1][C:2]1[O:3][CH:4]=[CH:5][C:6]=1[C:7]([OH:9])=O.S(Cl)([Cl:12])=O>>[I:1][C:2]1[O:3][CH:4]=[CH:5][C:6]=1[C:7]([Cl:12])=[O:9]Participants
3
Conditions
- Temperature
- 70 °C
Procedure
To 2-iodofuran-3-carboxylic acid (6.21 g, 26.1 mmol) was added thionyl chloride (20 ml, 274 mmol). The solution was heated while stirring to 70° C. for 5 h. The mixture was reduced in vacuo and the residue azeotroped with toluene (2×30 ml) to afford the crude title compound (6.69 g, 100%), which was used in the next step without further purification.
Workup
- temperatureThe solution was heated
- customthe residue azeotroped with toluene (2×30 ml)
Sources & evidence
- ORD record
- ord-beceb651d40c4d8eaf4e2b67f13b6f90
- Source dataset
- uspto-grants-2015_10
- Patent number
- US09156853B2
Linked notes
Loading…