HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorophenol → 2-[3-(4-Fluorophenoxy)propyl]-5,7-bis(propan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorophenol | HCID 9732 | — |
| Reactant | 3,5-Heptanedione, 2,6-dimethyl- | HCID 87597 | — |
| Reactant | HCID 178508402 | HCID 178508402 | — |
| Reactant | 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine | HCID 178508403 | — |
| Product | 2-[3-(4-Fluorophenoxy)propyl]-5,7-bis(propan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidine | HCID 76684793 | 61% |
| Product | 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine | HCID 178508403 | — |
Reaction Steps
The title compound was prepared according to the experimentals described for Example 22 above from 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine and 2,6-dimethyl-3,5-heptanedione in 61% yield. The reagent 3-[3-(4-fluorophenoxy)propyl]-1H-1,2,4-triazol-5-amine was prepared by a similar procedure for the synthesis of 3-[3-(4-chlorophenoxy)propyl]-1H-1,2,4-triazol-5-amine in Example 22 above, beginning from 4-fluorophenol instead of 4-chlorophenol. EM (calc.): 356.2; MS (ESI) m/e: 357.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09163027B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-0e8312fa9e09458bb6dc6af7b540ba54 |
| Source note | uspto-grants-2015_10 |